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News Article | August 8, 2017
Site: en.prnasia.com

Company receives $57M to Further Advance Biologics Development and Clinical Trials HANGZHOU, China, Aug. 8, 2017 /PRNewswire/ -- Dedicated to developing global antibody and recombinant protein bio-therapeutics, Hangzhou Just Biotherapeutics, Ltd. (Just China), today announced the completion of its Series B funding round. Temasek, an investment company headquartered in Singapore, leads the financing followed by existing investors Lilly Asia Ventures (LAV) and ARCH Venture Partners. New investors also include Taikang, Hangzhou Economic & Technological Development Area (HEDA), Bank of China (BOC) and Bank of Hangzhou. "The successful Series B financing indicates the continual faith of existing investors in Just China. We are also thankful to our new investors for their strong support," said Dr. Yining ZHAO, Co-founder and CEO of Just China. "Healthcare innovation in China has already entered into a new era. With joint efforts from all parties, Just China is committed to demonstrating the innovation in our products and business model, to truly accomplish our mission of providing good quality biotherapeutics for all." Located in the Hangzhou Economic & Technological Development Area, Just China's world-class R&D and manufacturing facility will be completed by the end of this year and operational in the first quarter of 2018. Construction and operations of the production center strictly adhere to cGMP standards and will be fully compliant with any country's regulations and guidelines for biopharmaceutical manufacturing. Globally, Just China has already established clinical development and CMC capabilities with a strong pipeline consisting of both bionovel and biosimilar products. Several leading programs will start to enter clinical stage in 2018. Just China was founded in February 2016 as a joint venture with Just Biotherapeutics, Inc. (Just), located in Seattle, Washington, USA. As an affiliate, Just China will have access to Just's integrated technology platform, J.DESIGN, and will closely partner with Just to evolve the platform. Applying J.DESIGN technology to molecule, process, product, manufacturing and plant design will enable Just China to develop biologics that meet global quality standards, while accelerating the development process and substantially reducing manufacturing cost. About Just. Founded in 2014, Just is led by an experienced team in the fields of protein, process and manufacturing sciences. The Just team came together to solve the scientific and technical hurdles that block access to life changing protein therapeutics; from the design of therapeutic molecules to the design of the manufacturing plants used to produce them. Our focus and passion is to create access and value for a global market through scientific and technological innovation. For more information on Just, please visit www.justbiochina.com. About Temasek. Incorporated in 1974, Temasek is an investment company headquartered in Singapore. Supported by 10 offices internationally, Temasek owns a S$275 billion (US$197 billion, EUR184 billion, GBP158 billion, RMB1.35 trillion)* portfolio as at 31 March 2017, mainly in Singapore and the rest of Asia. Our portfolio covers a broad spectrum of industries: financial services; telecommunications, media & technology; transportation & industrials; consumer & real estate; life sciences & agribusiness; as well as energy & resources. Our investment activities are guided by four investment themes and the long term trends they represent: Transforming Economies; Growing Middle Income Populations; Deepening Comparative Advantages; and Emerging Champions. For more information on Temasek, please visit www.temasek.com.sg About Taikang: Founded in 1996, Taikang is a large insurance and financial service conglomerate. The company operates through three main businesses: insurance, asset management and health and elderly care. Taikang Insurance Group has a number of subsidiaries which include Taikang Life, Taikang Asset, Taikang Pension, Taikang Community, Taikang Health and Tk.cn. Its business scope covers a wide range of fields, such as life insurance, pension, enterprise annuity, online property and casualty insurance, asset management, health and elderly care, health management, commercial real estate and offshore businesses. For more information on Taikang, please visit www.taikang.com.


News Article | August 8, 2017
Site: www.prnewswire.com

Temasek, an investment company headquartered in Singapore, leads the financing followed by existing investors Lilly Asia Ventures (LAV) and ARCH Venture Partners. New investors also include Taikang, Hangzhou Economic & Technological Development Area (HEDA), Bank of China (BOC) and Bank of Hangzhou. "The successful Series B financing indicates the continual faith of existing investors in Just China. We are also thankful to our new investors for their strong support," said Dr. Yining ZHAO, Co-founder and CEO of Just China. "Healthcare innovation in China has already entered into a new era. With joint efforts from all parties, Just China is committed to demonstrating the innovation in our products and business model, to truly accomplish our mission of providing good quality biotherapeutics for all." Located in the Hangzhou Economic & Technological Development Area, Just China's world-class R&D and manufacturing facility will be completed by the end of this year and operational in the first quarter of 2018. Construction and operations of the production center strictly adhere to cGMP standards and will be fully compliant with any country's regulations and guidelines for biopharmaceutical manufacturing. Globally, Just China has already established clinical development and CMC capabilities with a strong pipeline consisting of both bionovel and biosimilar products. Several leading programs will start to enter clinical stage in 2018. Just China was founded in February 2016 as a joint venture with Just Biotherapeutics, Inc. (Just), located in Seattle, Washington, USA. As an affiliate, Just China will have access to Just's integrated technology platform, J.DESIGN, and will closely partner with Just to evolve the platform. Applying J.DESIGN technology to molecule, process, product, manufacturing and plant design will enable Just China to develop biologics that meet global quality standards, while accelerating the development process and substantially reducing manufacturing cost. About Just. Founded in 2014, Just is led by an experienced team in the fields of protein, process and manufacturing sciences. The Just team came together to solve the scientific and technical hurdles that block access to life changing protein therapeutics; from the design of therapeutic molecules to the design of the manufacturing plants used to produce them. Our focus and passion is to create access and value for a global market through scientific and technological innovation. For more information on Just, please visit www.justbiochina.com. About Temasek. Incorporated in 1974, Temasek is an investment company headquartered in Singapore. Supported by 10 offices internationally, Temasek owns a S$275 billion (US$197 billion, EUR184 billion, GBP158 billion, RMB1.35 trillion)* portfolio as at 31 March 2017, mainly in Singapore and the rest of Asia. Our portfolio covers a broad spectrum of industries: financial services; telecommunications, media & technology; transportation & industrials; consumer & real estate; life sciences & agribusiness; as well as energy & resources. Our investment activities are guided by four investment themes and the long term trends they represent: Transforming Economies; Growing Middle Income Populations; Deepening Comparative Advantages; and Emerging Champions. For more information on Temasek, please visit www.temasek.com.sg About Taikang: Founded in 1996, Taikang is a large insurance and financial service conglomerate. The company operates through three main businesses: insurance, asset management and health and elderly care. Taikang Insurance Group has a number of subsidiaries which include Taikang Life, Taikang Asset, Taikang Pension, Taikang Community, Taikang Health and Tk.cn. Its business scope covers a wide range of fields, such as life insurance, pension, enterprise annuity, online property and casualty insurance, asset management, health and elderly care, health management, commercial real estate and offshore businesses. For more information on Taikang, please visit www.taikang.com.


"Umami Burger is always at the forefront of innovation when it comes to design and cuisine. We avoid simplicity and continue to build a consumer experience with multiple layers," says Sam Nazarian, Founder and CEO of sbe, Umami Burger's majority shareholder. "We've curated a boundary pushing experience at The Grove, showcasing Umami's influential brand through design and art collaborations, and creative culinary offerings." The announcement of Umami Burger's redesign at The Grove follows news of the company's first restaurant outside of the U.S., opening in Tokyo, spring 2017, and wildly successful partnership with Impossible Foods throughout Southern California locations. Also in the pipeline for Summer 2017 is a new location in New York City at the Hudson Hotel. Continuing to set the standard as an industry tastemaker, Umami Burger will debut new menu items at The Grove location, such as their buzzed-about Impossible Burger, the first plant-based, no meat patty that smells, taste, cooks and even "bleeds" like real beef, consisting of two patties, caramelized onions, American cheese, miso-mustard, house spread, dill pickles, lettuce, and tomato, and the Misoyaki Butterfish Burger with tempura butterfish, soy-soaked pepper relish, pickled carrot and daikon, daikon sprouts and sesame aioli, available only at The Grove. The restaurant group has also expanded its popular Slider Trio options to include the Hatch Burger, Truffle Burger, Manly Burger, Impossible Burger and Sam's Crispy Chicken Sandwich, while two new small bites have been added to the menu, including Shishito Peppers with a miso-sake glaze and parmesan and Spicy Edamame with soy, garlic, ginger, sesame, chili sauce and pepper mix. Also exclusive to The Grove and a continuation of the already advanced menu, Umami Burger will be offering its Umami-take on milkshakes – adding its perspective to the classic treat for the first time. Complete with boozy milkshakes, the milkshake menu offers unique flavors such as Hipster Hopper, a mint chocolate shake with Fernet-Branca and French Fry Hot Tub, a bourbon concoction with creme de cacao, caramel, coriander, salt and vanilla ice cream. Specializing in more than just its menu, with Umami Burger's philosophy to devise a space that is an experience for the senses, the re-designed Umami Burger brings to life the brand's playful, youthful, and vibrant nature. Designed by DESIGNAGENCY, the new look of The Grove, and all Umami Burger locations moving forward, is accessible, authentic, and spirited.  Incorporating polished concrete, neon feature signage, reclaimed and new charred wood, perforated metal paneling, leather, painted millwork edging, and custom graphics specific to each location, Umami Burger's design provides an elevated casual, accessible, and carefully curated environment. Split into three focal areas, Umami Burger at The Grove layers the new design with the brand's signature orange, black, and teal color palate, and use of Umami Burger "U" branding throughout. The host and main dining areas combine chocolate leather upholstery, multi artifact displays, rustic reclaimed wood canopies and a selection of circular banquette, booth, and table top seating, accommodating up to 73 diners. With a "social bar" serving as the focal point of the space and seating 11 guests, the bar uses large mosaic tile backsplash, a wood bar top, with bar stool seating. The large outdoor patio features multi-colored canopies, banquette seating, an exterior bar, wooden stump stools and concrete finish dining tables. Equipped with a play area for kids, providing a practical solution for parents and reiteration of accessibility to all, the space includes brightly colored graphic rubber flooring, with a use of geometric planters with chalkboard sides. The exterior patio can hold up to 40 guests. Umami Burger's new redesign makes the space perfect for accommodating large parties, private functions and semi-private events, such as birthdays, launch parties, sporting events and more – reaffirming the brand's 'social dining' vision and making it the place to bring your family and friends this summer. Umami at The Grove is located at 189 The Grove Drive Suite C-10 in Los Angeles and is open Monday through Thursday from 11 a.m. to 11 p.m. and until midnight Friday and Saturday. For more information on Umami Burger, visit umamiburger.com or follow @umamiburger or #umamiburger on Facebook, Twitter and Instagram. Founded in Los Angeles in 2009, Umami Burger has been named GQ's "Burger of the Year," Men's Journal's "Best Burger in America" and one of the "25 Most Innovative Consumer Brands of 2016" by Forbes' CircleUp25. Currently, Umami Burger has 24 restaurants in California, New York, Illinois and Nevada with additional locations planned around the world, including 10 locations in Japan. sbe, the Los Angeles-based leading lifestyle hospitality company that develops, manages and operates award-winning hospitality venues, is Umami Burger's majority shareholder. For more information on Umami Burger, please visit umamiburger.com or follow @umamiburger or #umamiburger on Facebook, Twitter and Instagram. Established in 2002 by Founder and CEO Sam Nazarian, sbe is a privately-held, leading lifestyle hospitality company that develops, manages and operates award-winning hotels, residences, restaurants and nightclubs. Through exclusive partnerships with cultural visionaries, sbe is devoted to creating extraordinary experiences throughout its proprietary brands with a commitment to authenticity, sophistication, mastery and innovation. Following the acquisition of Morgans Hotel Group, the pioneer of boutique lifestyle hotels, sbe has an unparalleled global portfolio featuring 23 world-class lifestyle hotel properties in 9 attractive gateway markets and more than 136 global world-renowned hotel, entertainment and food & beverage outlets. The company is uniquely positioned to offer a complete lifestyle experience - from nightlife, food & beverage and entertainment to hotels and residences, and through its innovative customer loyalty and rewards program, The Code, as well as its award-winning international real estate development subsidiary, Dakota Development - all of which solidify sbe as the preeminent leader across hospitality. sbe will continue its expansion with 13 hotel properties opening in the next two years (some with residences), including SLS Baha Mar, SLS Seattle, Mondrian Doha and Mondrian Dubai. The company's established and upcoming hotel brands include SLS Hotel & Residences, Delano, Mondrian, Redbury, Hyde Hotel & Residences, Clift, Hudson, Morgans, Royalton, Sanderson and St Martins Lane. In addition, sbe has the following internationally acclaimed restaurants and lounges: Katsuya, Cleo, The Bazaar by José Andrés, Fi'lia by Michael Schwartz, Umami Burger, Hyde Lounge and Skybar. More information about sbe can be obtained at sbe.com. Peroni Nastro Azzurro, Italy's No. 1 premium beer, is a crisp, refreshing lager that exudes Italian style. Created in 1963 in Italy, Peroni Nastro Azzurro launched in the United States in 2005, and today is enjoyed across six continents. Built on a foundation of excellence, Peroni Nastro Azzurro received its name in honour of the SS Rex – the only Italian ship to ever receive the 'Nastro Azzurro' award, given to the ship that crossed the Atlantic in the shortest time in an international competition. The SS Rex became a symbol of prestige for Italy and today the 'Nastro Azzurro' or 'Blue Ribbon' is displayed in Peroni Nastro Azzurro's name and branding as a symbol of the style, distinction and quality that Italy has been exporting to the world ever since. For more information, please visit www.peroniitaly.com. Founded in 2015, JUST is a consumer goods company dedicated to producing responsibly sourced quality products, contained in sustainably innovative packaging.  The first product, JUST water is 100% spring water ethically sourced from Upstate New York, packaged in a bottle made of 82% renewable resources.  The company mission to create environmental and social value along the supply chain, extends to partnerships with environmental non-profits, key members of the science and innovation community, as well as university collaborations, event alliances and community projects.  JUST water is sold in North America at over 15,000 retail locations.  For more information please visit www.justwater.com. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/umami-burger-at-the-grove-completely-reimagined--come-discover-the-new-summer-destination-300482103.html


News Article | June 6, 2017
Site: www.sciencenews.org

Tubelip wrasses eat dangerously, daring to dine on sharp corals lined with stinging cells. New images reveal the fish’s secret to safe eating: lubing up and planting a big one on their dinner. “It is like sucking dew off a stinging nettle. A thick layer of grease may help,” says David Bellwood, a marine biologist at James Cook University in Townsville, Australia, who snapped the shots with his colleague Victor Huertas. Of roughly 6,000 fish species that roam reefs, just 128 consume corals. These corallivores specialize in different menus. Well-studied butterfly fish, for example, use their long, thin snouts to nip up coral polyps, the tiny animals that build corals. Tubelip wrasses such as Labropsis australis of the South Pacific are known for nibbling coral with their luscious lips, but until now, it was unclear what part of the coral the fish were eating or how they were eating it. While the surface of the wrasse’s lips looks smooth to the naked eye, convoluted grooves appear under a scanning electron microscope, the team reports June 5 in Current Biology. Mucus-producing cells line each groove. In contrast, the lips of a wrasse species that doesn’t eat corals (Coris gaimard) are sleek and sport fewer slime-secreting cells. Video footage of L. australis shows that the fish feeds by latching onto coral with its lips and sucking. The slime probably protects the fish’s lips from stinging cells that line the coral skeleton and also serves as a sealant, allowing the wrasse to get suction against the coral’s razorlike ridges. “Their kiss is so hard it tears the coral’s flesh off its skeleton,” Bellwood says. The team suspects that the fish feed primarily on mucus layers and sometimes tissue that lines the sharp skeleton. So, essentially the fish are using their lip mucus to better harvest the coral’s mucus. Mucus is, in general, a hot commodity in the marine ecosystem. Some fish use it as sunscreen, others for speed — it can reduce drag through the water. Cleaner wrasses even eat slime off the skin of other fish (SN: 8/2/03, p. 78). Given the threats that coral reefs face from bleaching events and climate change, having fish that suck their flesh might seem a tad brutal. But whether the added stress of snot-eating fish serves as a mere nuisance or a serious threat remains to be studied.


Roy S.,JUST | Kabir I.,JUST | Al-Mamun K.M.A.,JUST
2016 International Conference on Innovations in Science, Engineering and Technology, ICISET 2016 | Year: 2016

Here, the optoelectronic performance of lattice matched InGaAs/InP vertical cavity surface emitting LASER is numerically simulated using MATLAB in (100), (110), (111), (113) and (131) crystal orientation by solving an eight-band k.p Hamiltonian using finite difference scheme including spin-orbit coupling. Tensor plane rotation formulae is applied to change the wave-vector k and Hamiltonian from orthodox (100) plane orientation. It is shown that there is a notable interrelationship between optical emission spectra and crystal plane orientations. The highest and lowest gains are estimated in (111) and (100) orientations with their respective peak emission wavelengths of 1770nm and 1680 nm at the carrier injection density of 2.5 × 1018 cm-3. The outcome of this paper would be a stimulus to design ultra-speed optoelectronic devices with performance amelioration by using non-100 oriented epitaxial layers. © 2016 IEEE.


Sahabuddin Md.,JUST
ICECTE 2016 - 2nd International Conference on Electrical, Computer and Telecommunication Engineering | Year: 2017

This article investigates the impact of cyber-attack on a power station in frequency disturbing aspects during sudden changes of load of the system and proposes a solution method to make it stable. Stable limit of the speed regulation for load frequency control (LFC) and integral controller gain for automatic generation control (AGC) is derived from their characteristic equations. Depending upon the nature of cyber-attack (positive biased or negative biased attack) simulations are performed to show the frequency deviations and oscillations of the power system. Finally a feedback LFC block with a three input switch is designed to remove these oscillations. © 2016 IEEE.


Diaz O.,University of New Mexico | Xu F.,University of New Mexico | Min-Allah N.,COMSATS Institute of Information Technology | Khodeir M.,JUST | And 3 more authors.
IEEE Communications Letters | Year: 2012

Network service recovery from multiple correlated failures is a major concern given the increased level of infrastructure vulnerability to natural disasters, massive power failures, and malicious attacks. To properly address this problem, a novel path protection solution is proposed to jointly incorporate traffic engineering and risk minimization objectives. The framework assumes probabilistic link failures and is evaluated against some existing multi-failure recovery schemes using network simulation. © 2012 IEEE.


Haddad B.,University of Jordan | Jarrah A.,JUST
Journal of Circuits, Systems and Computers | Year: 2013

Recent demand for low power VLSI circuits has been pushing the development of innovative approaches to reduce power dissipation. Supply voltage (V CC) and switching activity factor (α) are main sources of dynamic power dissipation in CMOS technology. Furthermore, the power dissipation increases exponentially by the value of supply voltage. New approach based on switching activity analysis and multiple supply voltage is implemented successfully in logical circuits, taking in mind the critical path(s) of the design and switching activity factor of each element in the design. High supply voltage is applied on elements on the critical path(s). Elements off the critical path(s) are classified into categories according to their switching activity factors. The total power dissipation is reduced, while the propagation delay remains without any increase. The proposed approach combines the concepts of critical/non-critical paths and switching activity analysis to assign different VCCs to different elements. © 2013 World Scientific Publishing Company.


Hamdan M.A.,University of Jordan | Al-Nimr M.A.,J.U.S.T. | Hammoudeh V.A.,University of Jordan
Journal of Fluids Engineering, Transactions of the ASME | Year: 2010

In this work, the effect of the second-order term to the velocityslip/temperature-jump boundary conditions on the solution of four cases in which the driving force is fluctuating harmonically was studied. The study aims to establish criteria that secure the use of the first order velocity-slip/temperature-jump model boundary conditions instead of the second-order ones. The four cases studied were the transient Couette flow, the pulsating Poiseuille flow, Stoke's second problem, and the transient natural convection flow. It was found that at any given Kn number, increasing the driving force frequency, increases the difference between the first and second-order models. Assuming that a difference between the two models of over 5% is significant enough to justify the use of the more complex second-order model, the critical frequencies for the four different cases were found. For the cases for which the flow is induced by the fluctuating wall as in cases 1 and 3, we found that critical frequency at Kn=0.1 to be ω=8. For the cases of flow driven by a fluctuating pressure gradient as in case 2, this frequency was found to be ω = 1, at the same Kn number. In case 4, for the temperature-jump model, the critical frequency was found to beω = 7 and for the velocity-slip model the critical frequency at the same Kn number was found to be ω = 1.35. Copyright © 2010 by ASME.


Trademark
Just | Date: 2015-11-06

Computer software to enable uploading, downloading, accessing, posting, displaying, and otherwise providing electronic media and information related to the fashion industry via computer and communication networks; computer software for accessing, browsing and searching online databases related to the fashion industry.

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