Entity

Time filter

Source Type

Mumbai, India

Thorat B.R.,P.A. College | Jagtap R.,University of Rajasthan | Thorat V.B.,Junior College | Khemanar A.,Institute of Science | Yamgar R.S.,Patkar Varde College
Der Pharma Chemica | Year: 2015

The 7-methoxy-2-(4-thiomethylphenyl)-1-benzofuran-5-carbaldehyde was synthesised by known literature method (Wittig reaction approach) from vanillin. To deduce the anticancer and antibacterial activity of the 7-methoxy-2-(4-thiomethylphenyl)-1-benzofuran-5-carbaldehyde, it is docked with different biomarkers of cancer cell and bacteria. Grid was generated for each oncoproteins by specifying the active site amino acids. The binding model of best scoring analogue with each protein was assessed from their G-scores and disclosed by docking analysis using the XP visualizer tool. An analysis of the receptor-ligand interaction studies revealed that 7-methoxy-2-(4-thiomethylphenyl)-1-benzofuran-5-carbaldehyde is most active against 1BAG and 4FNY biomarkers and have the features to prove themselves as anticancer drugs. It shows strong cytotoxicity against human cell line [lung (A-459) and breast (MCF-07)]. Source


Zhao X.Q.,CAS Nanjing Institute of Soil Science | Guo S.W.,Jiangsu Academy of Agricultural Sciences | Shinmachi F.,Junior College | Sunairi M.,Nihon University | And 3 more authors.
Annals of Botany | Year: 2013

Background and AimsAcidic soils are dominated chemically by more ammonium and more available, so more potentially toxic, aluminium compared with neutral to calcareous soils, which are characterized by more nitrate and less available, so less toxic, aluminium. However, it is not known whether aluminium tolerance and nitrogen source preference are linked in plants.MethodsThis question was investigated by comparing the responses of 30 rice (Oryza sativa) varieties (15 subsp. japonica cultivars and 15 subsp. indica cultivars) to aluminium, various ammonium/nitrate ratios and their combinations under acidic solution conditions.Key Resultsindica rice plants were generally found to be aluminium-sensitive and nitrate-preferring, while japonica cultivars were aluminium-tolerant and relatively ammonium-preferring. Aluminium tolerance of different rice varieties was significantly negatively correlated with their nitrate preference. Furthermore, aluminium enhanced ammonium-fed rice growth but inhibited nitrate-fed rice growth.ConclusionsThe results suggest that aluminium tolerance in rice is antagonistic with nitrate preference and synergistic with ammonium preference under acidic solution conditions. A schematic diagram summarizing the interactions of aluminium and nitrogen in soil-plant ecosystems is presented and provides a new basis for the integrated management of acidic soils. © 2012 The Author. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. Source


Hall P.,University of Melbourne | Love H.A.,University of South Dakota | Uesugi S.,Junior College
IEEE Technology and Society Magazine | Year: 2015

The articles in this special section focus on the work and life of Dr. Norbert Wiener (1894-1964), who is considered one of the quintessential multi-disciplinarians of our time. He is considered the "Father of Cybernetics." During his life, Wiener influenced mathematics, philosophy, science, technology, ethics, biology, prosthesis, education, manufacturing, and many other fields. He was an early practitioner of diversity and social inclusion, and an advocate of social responsibility in the development of technology. He predicted the social impact of robotic, cybernetic, and other technologies on the future of society, and after several decades his writings retain their relevance. © 2015 IEEE. Source


Thorata B.,P.A. College | Jagatapb R.,University of Rajasthan | Thoratc V.B.,Junior College | Mandewalea M.,P.A. College | And 2 more authors.
Der Pharma Chemica | Year: 2015

The 7-methoxy-2-(3,4-dimethoxyphenyl)-1-benzofuran-5-carbaldehyde was synthesized by known literature method (Wittig reaction approach) from vanillin. To deduce the anticancer and antibacterial activity of the 7-methoxy-2-(3,4-dimethoxyphenyl)-1-benzofuran-5-carbaldehyde, it is docked with different biomarkers of cancer cell and bacteria. Grid was generated for each oncoproteins by specifying the active site amino acids. The binding model of best scoring analogue with each protein was assessed from their G-scores and disclosed by docking analysis using the XP visualizer tool. An analysis of the receptor-ligand interaction studies revealed that 7-methoxy-2-(3,4-dimethoxyphenyl)-1-benzofuran-5-carbaldehyde is most active against 3LAU (Arora 2 kinase) and 1VOM (Dictyostelium myosin) biomarkers and have the features to prove themselves as anticancer drugs. The Cramer rules of toxicity predicts the toxicological hazard (when administered orally) from the molecular structure. It shows that it is class III toxic compound. Also stereochemistry and molecular parameters are studied by using Avogadro's software. Both MB and MTT assay shows that, 7-methoxy-2-(3,4-dimethoxyphenyl)-1-benzofuran-5-carbaldehyde is strong cytotoxic against (A-459) human lung cell line than (MCF-07) breast cancer cell line. Source


Saito S.,Junior College | Tomonaga N.,Polytechnic Center | Kuwano R.,Polytechnic University of Mozambique | Fujii N.,Polytechnic University of Mozambique
Keikinzoku Yosetsu/Journal of Light Metal Welding and Construction | Year: 2012

Recently, the digital inverter type pulse (DP) welding machine has used widely for MIG welding machine. This DP welding machine is superior to the usual welding machines in respect of the workability. However, the handling of DP welding machine and the welding parameters are not known well for the persons concerned in welding at the present time. It is mentioned as an example that the ratio of successful applicants in the welding performance qualification (WPQ) is only a little better compared with before. In this study, the welding parameters of DP welding machine were investigated from the appearance of the bead when the torch angle and welding direction are changed and the droplet transfer phenomenon. In addition, the examples of the optimum welding parameters were examined for the WPQ. The results were as follows. • It was preferred to weld by the forehand angle in MIG welding of aluminium alloy. • Under the standard condition included in DP welding machine, the arc was stable, the sputter decreased, and appearance of the bead was satisfactory. • The validity of examples of the optimum welding parameters was confirmed by the results of the X-ray radiography and the bending test. Source

Discover hidden collaborations