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Koesan, South Korea

Choi H.K.,Jungwon University | Lee K.,Dongguk University
Archives of Pharmacal Research

Heat shock protein 90 (Hsp90) plays a critical role in the maintenance of multiple oncogenic pathways and is a required protein for folding and stability of many oncoproteins that are related to the growth, proliferation, and survival of many kinds of cancers. Ganetespib (STA-9090) is a potent, synthetic, small molecule inhibitor of Hsp90, and its binding to Hsp90 is known to result in the degradation of its client proteins and subsequent death of cancer cells. This article provides a review of ganetespib as one of the leading Hsp90 inhibitors, which is under investigation in a broad range of clinical stages for the treatment of cancer. © 2012 The Pharmaceutical Society of Korea and Springer Science+Business Media Dordrecht. Source

Lee J.-W.,Jungwon University
Foundations of Physics

It is suggested that quantum mechanics is not fundamental but emerges from classical information theory applied to causal horizons. The path integral quantization and quantum randomness can be derived by considering information loss of fields or particles crossing Rindler horizons for accelerating observers. This implies that information is one of the fundamental roots of all physical phenomena. The connection between this theory and Verlinde's entropic gravity theory is also investigated. © 2010 Springer Science+Business Media, LLC. Source

Lee J.-W.,Jungwon University
Journal of the Korean Physical Society

The first law of thermodynamics and the holographic principle applied to an arbitrary large cosmic causal horizon are shown to naturally demand a zero cosmological constant and a non-zero dynamical dark energy in the form of the holographic dark energy. A semiclassical analysis shows that the holographic dark energy has a parameter d = 1 and an equation of state comparable to current observational data if the entropy of the horizon saturates the Bekenstein-Hawking bound. This result indicates that quantum field theory should be modified on a large scale to explain the dark energy. The relations among the dark energy, the quantum vacuum energy and the entropic gravity are also discussed. © 2013 The Korean Physical Society. Source

Lin M.M.,Tsinghua University | Kim D.K.,Jungwon University
Journal of Nanoparticle Research

A novel strategy for the fabrication of nanostructured materials based on preparation of metallic surfactants is presented and some examples are demonstrated in this article. The suggested synthetic procedure of metal oleate is universal, potentially able to produce bulk quantities, and can be applicable to the synthesis of other metal oxide and metal nanoparticles. In general, organometallic compounds are quite expensive and are mostly classified as a highly toxic substance. In this study, we used simple, inexpensive, and eco-friendly approaches to prepare the metallic surfactants. As an example, non-hydrated iron oleate (FeOl) complexes are prepared as precursors for the in situ-fabricated superparamagnetic iron oxide nanoparticles (SPIONs) by thermolysis. The different coordination of the non-hydrated FeOl complexes are directly relating to the competition between nucleation and crystal growth. The in situ preparation of SPIONs involves the reaction of metal nitrate and carboxylic acid at 120 ° C to synthesize the non-hydrated FeOl complexes and following the thermolysis of FeOl at 300 ° C in non-coordination solvent. The coordination modes and distinct thermal behaviors of intermediates non-hydrated FeOl complexes are comparatively investigated by means of thermo-analytic techniques complimented by differential scanning calorimetry, thermal gravimetric analysis (TGA) and infrared spectroscopy (FTIR). The potential chemical structures of non-hydrated FeOl and their reaction mechanism by thermolysis were elucidated. The resulting lipid-coated SPIONs were characterized by transmission electron microscope, FTIR, differential temperature analysis, and TGA. These data suggested a bimodal interaction of organic shell and nanoparticle surface, with chemically absorbed inner layer and physically absorbed outer layer of carboxylic acid. © Springer Science+Business Media B.V. 2012. Source

Atopic dermatitis,which is related to dermatologic disorders and is associatedwith skin barrier dysfunction, represents an epidemic problem demanding effective therapeutic strategies. In the present study, we showed that the treatment with Eruca sativa extract resulted in a significant increase in the transactivation activity of peroxisome proliferator-activated receptor (PPAR) response element such as PPAR-α and suppression in the expression of inflammatory cytokine and antimicrobial peptides. In addition, E. sativa extract promotes the expression of filaggrin related to skin barrier protection. Quercetin and isorhamnetin, flavonoids' constituents of E. sativa, also promoted PPAR-α activity. These results indicate that E. sativa extract may be an appropriate material for improving skin barrier function as a skin therapeutic agent for atopic dermatitis. Copyright © 2014 John Wiley & Sons, Ltd. Source

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