Jundiaí, Brazil
Jundiaí, Brazil

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Cunha P.R.,Jundiai Medical School | Scabine Pessotti N.,Jundiai Medical School | Bonati Mattos C.,Jundiai Medical School | Salai A.F.,Jundiai Medical School
Dermatologic therapy | Year: 2017

The aim of this study is to evaluate the use of fractional carbon dioxide laser (CO2 ) with betamethasone and salicylic acid solution in the treatment of patients with refractory vitiligo in hands. Each hand of the patient was randomly assigned to one of two groups: lesion treated with fractional carbon dioxide laser associated with betamethasone and salicylic acid solution administration or lesion treated only with betamethasone and salicylic acid solution. We conclude that combined treatment with fractional carbon dioxide laser and betamethasone associated with salicylic acid solution could effectively and safely be used in the treatment of refractory vitiligo. © 2016 Wiley Periodicals, Inc.


Cecato J.F.,Jundiai Medical School | Fiorese B.,Anhanguera | Montiel J.M.,Anhanguera | Bartholomeu D.,Laboratory of Psychodiagnostic and Cognitive Neurosciencies | Martinelli J.E.,Jundiai Medical School
American Journal of Alzheimer's Disease and other Dementias | Year: 2012

Objective: The aim of this study was to describe the performance in Clock Drawing Test (CDT) of the elderly individuals assessed in a geriatric clinic, with at least 1 year of schooling, comparing with other groups with higher education and with Clinical Dementia Rating (CDR) levels. The study also aims to correlate the results of CDT and other used diagnostic tests for dementia by CDR levels, providing additional validity evidence to the CDT. Methods: Cross-sectional study with 426 elderly individuals, >60 years old and at least 1 year of education. All participants searched for medical assistance at Geriatric and Gerontology Ambulatory of Jundiaí city, in Brazil. The community-dwelling outpatients previously undergone a detailed clinical examination and neuropsychological evaluation: Cambrigde Cognitive Examination (CAMCOG), Mini-Mental State Examination (MMSE), andCDT. To differentiate data from diagnostic groups based on CDR, it Kruskal-Wallis test was used. Pearson statistics were calculated to compare data from CDT and CDR. The statistical analyses were 2-tailed and were considered significant when P < .05. Results: Regarding CDT, groups with more years of schooling showed similar means in CDR = 0 and CDR = 0.5 and in CDR = 1 and CDR = 2. Shulman and Sunderland scale were high score in groups with more years of education and above of cutoff points in all CDT score. On the contrary, in Mendez scale we did not observed similar means. Otherwise, in the group with less years of schooling greater means differences in the CDT were observed. Conclusion: The CDT did not show a strong correlation with MMSE and CAMCOG, both important instruments in Brazilian population to investigate dementia. For elderly individuals with high education levels, the CDT did not seem to be a good test to detect cognitive impairment. © The Author(s) 2012.


de Oliveira A.M.,University of Sao Paulo | Rondo P.H.C.,University of Sao Paulo | Luzia L.A.,University of Sao Paulo | D'Abronzo F.H.,Jundiai Medical School | Illison V.K.,University of Sao Paulo
Diabetes Research and Clinical Practice | Year: 2011

Antioxidants probably play an important role in the etiology of type 2 diabetes (DM2). This study evaluated the effects of supplementation with lipoic acid (LA) and α-tocopherol on the lipid profile and insulin sensitivity of DM2 patients.A randomized, double-blind, placebo-controlled trial involving 102 DM2 patients divided into four groups to receive daily supplementation for 4 months with: 600. mg LA (n = 26); 800. mg α-tocopherol (n = 25); 800. mg α-tocopherol. +. 600. mg LA (n = 25); placebo (n = 26). Plasma α-tocopherol, lipid profile, glucose, insulin, and the HOMA index were determined before and after supplementation. Differences within and between groups were compared by ANOVA using Bonferroni correction. Student's t-test was used to compare means of two independent variables. The vitamin E/total cholesterol ratio improved significantly in patients supplemented with vitamin E. +. LA and vitamin E alone (p≤ 0.001). There were improvements of the lipid fractions in the groups receiving LA and vitamin E alone or in combination, and on the HOMA index in the LA group, but not significant. The results suggest that LA and vitamin E supplementation alone or in combination did not affect the lipid profile or insulin sensitivity of DM2 patients. © 2011 Elsevier Ireland Ltd.


Aprahamian I.,Jundiai Medical School | Aprahamian I.,University of Sao Paulo | Martinelli J.E.,Jundiai Medical School | Cecato J.,Jundiai Medical School | Yassuda M.S.,Gerontology
Journal of Alzheimer's Disease | Year: 2011

One of the challenges in screening for dementia in developing countries is related to performance differences due to educational and cultural factors. This study evaluated the accuracy of single screening tests as well as combined protocols including the Mini-Mental State Examination (MMSE), Verbal Fluency animal category (VF), Clock Drawing test (CDT), and Pfeffer Functional Activities Questionnaire (PFAQ) to discriminate illiterate elderly with and without Alzheimer's disease (AD) in a clinical sample. Cross-sectional study with 66 illiterate outpatients diagnosed with mild and moderate AD and 40 illiterate normal controls. Diagnosis of AD was based on NINCDS-ADRDA. All patients were submitted to a diagnostic protocol including a clinical interview based on the CAMDEX sections. ROC curves area analyses were carried out to compare sensitivity and specificity for the cognitive tests to differentiate the two groups (each test separately and in two by two combinations). Scores for all cognitive (MMSE, CDT, VF) and functional assessments (PFAQ) were significantly different between the two groups (p < 0.001). The best screening instruments for this sample of illiterate elderly were the MMSE and the PFAQ. The cut-off scores for the MMSE, VF, CDT, and PFAQ were 17.5, 7.5, 2.5, and 11.5, respectively. The most sensitive combination came from the MMSE and PFAQ (94.1%), and the best specificity was observed with the combination of the MMSE and CDT (89%). Illiterate patients can be successfully screened for AD using well-known screening instruments, especially in combined protocols. © 2011-IOS Press and the authors. All rights reserved.


Illison V.K.,University of Sao Paulo | Rondo P.H.,University of Sao Paulo | de Oliveira A.M.,University of Sao Paulo | D'Abronzo F.H.,Jundiai Medical School | Campos K.F.,University of Sao Paulo
International Journal for Vitamin and Nutrition Research | Year: 2011

Type 2 diabetes mellitus (DM2) predisposes to an increased production of free radicals and a probable reduction in plasma antioxidants, including vitamin E. This cross-sectional study investigated the relationship between plasma α-tocopherol concentration and vitamin E intake in 58 Brazilians with DM2. Plasma α-tocopherol was determined by high-performance liquid chromatography. The intake of vitamin E-rich foods was assessed by a food frequency questionnaire. Total cholesterol and fractions were measured by colorimetric enzymatic methods. Data on demographic and socioeconomic factors, life habits, and anthropometry were obtained by a questionnaire and physical examination. The association between plasma α-tocopherol and vitamin E intake was assessed by multiple linear regression analysis. The following variables were included in the regression model: α-tocopherol, vitamin E intake, total cholesterol and fractions, body mass index, waist circumference, gender, age, education, occupation, income, smoking, alcohol intake, and blood pressure. There was no association between α-tocopherol and vitamin E intake, but there were significant associations between α-tocopherol and total cholesterol (p < 0.001) and waist circumference (p = 0.003). There were 36.2 % diabetics with low α-tocopherol concentrations (< 12 μmol/L) and 32.7 % with a low α-tocopherol/total cholesterol ratio (< 2.2). Further large, epidemiological, longitudinal studies, including measurements of gamma-tocopherol in blood, should be conducted to confirm our results. © 2011 by Hans Huber Publishers, Hogrefe AG, Bern.


Passos S.D.,Jundiai Medical School | Gazeta R.E.,University of Sao Paulo | Felgueiras A.P.,Jundiai Medical School | Beneli P.C.,University of Sao Paulo | Coelho M.D.S.Z.S.,University of Sao Paulo
Revista da Associacao Medica Brasileira | Year: 2014

To review if pollution and climate changes can influence respiratory tract infections in children. Data source: Articles published on the subject in PubMed, Sci- ELO, Bireme, EBSCO and UpTodate were reviewed. The following inclusion criteria were considered: scientific papers between 2002 and 2012, study design, the pediatric population, reference documents such as the CETESB and World Health Organization Summary of the data: We analyzed research that correlated respiratory viruses and climate and/or pollution changes. Respiratory syncytial virus has been the virus related most to changes in climate and humidity. Other "old and new" respiratory viruses such as Human Bocavirus, Metapneumovirus, Parechovirus and Parainfuenza would need to be investigated owing to their clinical importance. Although much has been studied with regard to the relationship between climate change and public health, specific studies about its influence on children's health remain scarce.


PubMed | Mogi Das Cruzes University, Jundiai Medical School, Universitary Center Sao Camilo, Anhembi Morumbi University and 2 more.
Type: Journal Article | Journal: Transplantation proceedings | Year: 2016

The goal of this study was to investigate whether exogenous offer of L-arginine (LARG) modulates the gene expression of intestinal dysfunction caused by ischemia and reperfusion.Eighteen Wistar-EPM1 male rats (250-300g) were anesthetized and subjected to laparotomy. The superior mesenteric vessels were exposed, and the rats were randomized into 3 groups (n= 6): the control group (CG), with no superior mesenteric artery interruption; the ischemia/reperfusion group (IRG), with 60 minutes of ischemia and 120 minutes of reperfusion and saline injections; and the L-arginine group (IRG+ LARG), with L-arginine injected in the femoral vein 5 minutes before ischemia, 5 minutes after reperfusion, and after 55 minutes of reperfusion. The total RNA was extracted and purified from samples of the small intestine. The concentration of each total RNA sample was determined by using spectrophotometry. The first-strand complementary DNA (cDNA) was synthesized in equal amounts of cDNA and the Master Mix SYBR Green qPCR Mastermix (SABiosciences, a Qiagen Company, Frederick, Md). Amounts of cDNA and Master Mix SYBR Green qPCR Mastermix were distributed to each well of the polymerase chain reaction microarray plate containing the predispensed gene-specific primer sets for Bax and Bcl2. Each sample was evaluated in triplicate, and the Student t test was applied to validate the homogeneity of each gene expression reaction (P< .05).The gene expression of Bax in IRG (+1.48) was significantly higher than in IRG-LARG (+9.69); the expression of Bcl2L1 in IRG (+1.01) was significantly higher than IRG-LARG (+22.89).The apoptotic cell pathway of 2 protagonists showed that LARG improves the gene expression of anti-apoptotic Bcl2l1 (Bcl2-like 1) more than the pro-apoptotic Bax (Bcl2-associated X protein).


Faundes A.,University of Campinas | Duarte G.A.,Cemicamp | de Sousa M.H.,Cemicamp | Soares Camargo R.P.,Jundiai Medical School | Pacagnella R.C.,University of Campinas
Reproductive Health Matters | Year: 2013

Unsafe abortions remain a major public health problem in countries with very restrictive abortion laws. In Brazil, parliamentarians - who have the power to change the law - are influenced by "public opinion", often obtained through surveys and opinion polls. This paper presents the findings from two studies. One was carried out in February-December 2010 among 1,660 public servants and the other in February-July 2011 with 874 medical students from three medical schools, both in São Paulo State, Brazil. Both groups of respondents were asked two sets of questions to obtain their opinion about abortion: 1) under which circumstances abortion should be permitted by law, and 2) whether or not women in general and women they knew who had had an abortion should be punished with prison, as Brazilian law mandates. The differences in their answers were enormous: the majority of respondents were against putting women who have had abortions in prison. Almost 60% of civil servants and 25% of medical students knew at least one woman who had had an illegal abortion; 85% of medical students and 83% of civil servants thought this person(s) should not be jailed. Brazilian parliamentarians who are currently reviewing a reform in the Penal Code need to have this information urgently. © 2013 Reproductive Health Matters.


Martin L.F.,São Paulo State University | Moco N.P.,São Paulo State University | Ramos B.R.A.,São Paulo State University | Camargo R.P.S.,Jundiai Medical School | Silva M.G.,São Paulo State University
European Journal of Obstetrics Gynecology and Reproductive Biology | Year: 2014

Objective To evaluate the concentration of PTX3 in amniotic fluid (AF) during the final weeks of normal pregnancies and in pregnancies complicated by preterm delivery (PTD). Study design A cross-sectional study was conducted with 95 pregnant women followed to term and 25 who presented with PTD. Samples of AF from all patients were obtained during cesarean section and the PTX3 concentration was determined by enzyme immunoassay (ELISA). Maternal characteristics were compared by ANOVA and the Kruskal-Wallis and Chi square tests. Comparison between PTX3 concentrations in the "PTD in labor" and "PTD not in labor" groups were performed using the Mann-Whitney test. A p value <0.05 was considered statistically significant. Results Regarding term pregnancies, PTX3 concentrations were not statistically different across the period studied (37 weeks to 40 weeks). Among preterm pregnancies, those in preterm labor (PTL) presented higher PTX3 levels than those not in labor (p = 0.001) and the risk of occurrence of PTL increased by 1% with a rise of 1 pg/mL in PTX3. Conclusion PTX3 is a physiological constituent of the AF, and its concentration is elevated in the presence of spontaneous PTL, reinforcing the theory that PTX3 plays a role in the innate immune response during gestational complications associated with infectious/inflammatory conditions. © 2014 Elsevier Ireland Ltd.


Huesmann T.,University of Munster | Cunha P.R.,Jundiai Medical School | Osada N.,University of Munster | Huesmann M.,University of Munster | And 5 more authors.
Acta Dermato-Venereologica | Year: 2012

Notalgia paraesthetica is a neuropathic pruritus on the back. The aim of this retrospective study was to examine patient characteristics in a consecutive cohort from Brazil and Germany. A total of 65 patients (49 women, 16 men; age range 25-80 years, mean 56.2 ± 12.7 years; median 57.0 years) were investigated in order to determine the spinal or peripheral origin of notalgia paraesthetica. Protein gene product 9.5-positive intraepidermal nerve fbers were signifcantly reduced in the pruritic compared with the non-lesional area (p < 0.05). In 32.3% of patients, radiological examinations showed a stenosis and in 47.7% a degeneration. A correlation between the radiological fndings and the exact dermatomal localization of notalgia paraesthetica was found in 15.7% of the involved areas. The signifcant reduction in intraepi-dermal nerve fber density suggests that damage to the peripheral nerves is a more important aetiological factor than spinal changes in notalgia paraesthetica. © 2012 The Authors.

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