Judge Baker Childrens Center

Boston, MA, United States

Judge Baker Childrens Center

Boston, MA, United States
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Park K.H.,Beth Israel Deaconess Medical Center | Park K.H.,Hallym University | Zaichenko L.,Beth Israel Deaconess Medical Center | Brinkoetter M.,Beth Israel Deaconess Medical Center | And 11 more authors.
Journal of Clinical Endocrinology and Metabolism | Year: 2013

Context: Irisin, a recently identified hormone, has been proposed to regulate energy homeostasis and obesity in mice. Whether irisin levels are associated with risk of the metabolic syndrome (MetS), cardiometabolic variables, and cardiovascular disease (CVD) risk in humans remains unknown. Objective: Our objective was to assess the associations between baseline serum irisin levels and MetS, cardiometabolic variables, and CVD risk. Design, Setting, and Subjects: We conducted a comparative cross-sectional evaluation of baseline circulating levels of the novel hormone irisin and the established adipokine adiponectin with MetS, cardiometabolic variables, and CVD risk in a sample of 151 subjects. Results: Baseline irisin levels were significantly higher in subjects with MetS than in subjects without MetS. Irisin was associated negatively with adiponectin (r = -0.4, P<.001) and positively with body mass index (r= 0.22, P=.008), systolic (r = 0.17, P = .04) and diastolic (r = 0.27, P=.001) blood pressure, fasting glucose (r = 0.25, P = .002), triglycerides (r = 0.25, P = .003), and homeostasis model assessment for insulin resistance (r = 0.33, P < .001). After adjustment for potential confounders, including body mass index, subjects in the highest tertile of irisin levels were more likely to have MetS (odds ratio [OR] = 9.44, 95% confidence interval [CI] = 2.66-33.44), elevated fasting blood glucose (OR = 5.80, 95% CI = 1.72-19.60), high triglycerides (OR = 3.89, 95% CI = 1.16-13.03), and low high-density lipoprotein cholesterol (OR = 3.30, 95% CI = 1.18-9.20). Irisin was independently associated with homeostasis model assessment for insulin resistance and general Framingham risk profile in multiple linear regression analyses after adjustment for confounders. Adiponectin demonstrated the expected associations with outcomes. Conclusions: Irisin is associated with increased risk of MetS, cardiometabolic variables, and CVD in humans, indicating either increased secretion by adipose/muscle tissue and/or a compensatory increase of irisin to overcome an underlying irisin resistance in these subjects. © 2013 by The Endocrine Society.


Park K.H.,Beth Israel Deaconess Medical Center | Park K.H.,Hallym University | Zaichenko L.,Beth Israel Deaconess Medical Center | Peter P.,Beth Israel Deaconess Medical Center | And 4 more authors.
Metabolism: Clinical and Experimental | Year: 2014

Objective Adherence to a healthy diet has been shown to decrease the incidence of obesity and associated comorbidities. C-reactive protein (CRP) is an established inflammatory marker and irisin was recently identified as a molecule which may play a role in energy regulation and obesity but whether diet alters irisin levels remains unknown. We aimed to investigate the association between circulating irisin, leptin, and CRP levels and dietary quantity and quality using the Alternate Healthy Eating Index (AHEI) and the Alternate Mediterranean Diet Score (aMED). Materials/Methods The study evaluated dietary data and biomarker levels of 151 participants between 2009 and 2011 (71 male vs. 80 female, over 35 years old, obese 43.7%). AHEI and aMED scores were calculated based on data derived from self-administered 110-item food-frequency questionnaires estimating usual nutrient intake over the past year. Cross-sectional associations between dietary quantity, quality, body composition by bioelectric impedance, and biomarker levels including irisin, leptin, and CRP after fasting were assessed. Results CRP, but not irisin, was negatively correlated with AHEI (r = - 0.34) and aMED (r = - 0.31). Irisin was positively correlated with BMI (r = 0.22), fat mass (r = 0.21), waist circumference (r = 0.24), waist-hip ratio (r = 0.20), leptin (r = 0.32), and CRP (r = 0.25). Participants with the highest AHEI scores tended to have 11.6% lower concentrations of irisin (P for trend = 0.09), but they were not significant after adjustment for potential confounders. Better diet quality was associated with lower CRP concentrations (P for trend = 0.02) in multivariate model. Percentage of energy from carbohydrate was inversely associated with CRP. Conclusions Unlike CRP, irisin is not associated with dietary quality or quantity. © 2014 Elsevier Inc.


Gladstone T.R.G.,Wellesley College | Gladstone T.R.G.,Childrens Hospital | Gladstone T.R.G.,Judge Baker Childrens Center | Beardslee W.R.,Childrens Hospital | And 3 more authors.
Psychiatric Clinics of North America | Year: 2011

This article provides a conceptual framework for research and outlines several new directions for the same on the prevention of depression in youth and reviews the recent literature on prevention efforts targeting children and adolescents. Prevention efforts should target both specific and nonspecific risk factors, enhance protective factors, use a developmental approach, and target selective and/or indicated samples. A review of the literature indicates that prevention programs using cognitive-behavioral and/or interpersonal approaches and family-based prevention strategies are the most helpful. Overall, it seems that there is reason for hope regarding the role of interventions in preventing depressive disorders in youth. © 2011 Elsevier Inc.


Beardslee W.R.,Childrens Hospital | Beardslee W.R.,Judge Baker Childrens Center | Gladstone T.R.G.,Childrens Hospital | Gladstone T.R.G.,Judge Baker Childrens Center | And 2 more authors.
Child and Adolescent Psychiatric Clinics of North America | Year: 2012

An understanding of risk and resiliency drives the development of prevention programs for youth depression, and enables researchers to make careful choices about the prevention strategies they use. A key early stage of prevention research involves understanding specific and nonspecific risk and protective factors, as prevention efforts that work benefit from a focus on decreasing risk factors and enhancing protective factors for a particular disorder. Research and clinical implications of advancements in this area are reviewed in the text that follows. © 2012 Elsevier Inc.


Ferguson C.J.,Texas A&M International University | Olson C.K.,Massachusetts General Hospital | Kutner L.A.,Massachusetts General Hospital | Warner D.E.,Judge Baker Childrens Center
Crime and Delinquency | Year: 2014

The effects of violent video game exposure on youth aggression remain an issue of significant controversy and debate. It is not yet clear whether violent video games uniquely contribute to long-term youth aggression or whether any relationship is better explained through third variables such as aggressive personality or family environment. The current study examines the influence of violent video game exposure on delinquency and bullying behavior in 1,254 seventh- and eighth-grade students. Variables such as parental involvement, trait aggression, stress, participation in extracurricular activities, and family/peer support were also considered. Results indicated that delinquent and bullying behavior were predicted by the child's trait aggression and stress level. Violent video game exposure was not found to be predictive of delinquency or bullying, nor was level of parental involvement. These results question the commonly held belief that violent video games are related to youth delinquency and bullying. © 2010 SAGE Publications.


Langer D.A.,University of California at Los Angeles | Langer D.A.,Judge Baker Childrens Center | McLeod B.D.,Virginia Commonwealth University | Weisz J.R.,Harvard University
Journal of Consulting and Clinical Psychology | Year: 2011

Objective: Some critics of treatment manuals have argued that their use may undermine the quality of the client-therapist alliance. This notion was tested in the context of youth psychotherapy delivered by therapists in community clinics. Method: Seventy-six clinically referred youths (57 female, age 8-15 years, 34 Caucasian) were randomly assigned to receive nonmanualized usual care or manual-guided treatment to address anxiety or depressive disorders. Treatment was provided in community clinics by clinic therapists randomly assigned to treatment condition. Youth-therapist alliance was measured with the Therapy Process Observational Coding System - Alliance (TPOCS-A) scale at 4 points throughout treatment and with the youth report Therapeutic Alliance Scale for Children (TASC) at the end of treatment. Results: Youths who received manual-guided treatment had significantly higher observer-rated alliance than usual care youths early in treatment; the 2 groups converged over time, and mean observer-rated alliance did not differ by condition. Similarly, the manual-guided and usual care groups did not differ on youth report of alliance. Conclusions: Our findings did not support the contention that using manuals to guide treatment harms the youth-therapist alliance. In fact, use of manuals was related to a stronger alliance in the early phase of treatment. © 2011 American Psychological Association.


Waber D.P.,Childrens Hospital Boston | Eaglesfield D.,Judge Baker Childrens Center | Fitzmaurice G.M.,McLean Hospital | Bryce C.,Barbados Nutrition Study | Galler J.R.,Judge Baker Childrens Center
Journal of Developmental and Behavioral Pediatrics | Year: 2011

Objective: Depressive symptoms are elevated in adolescents who experienced significant malnutrition early in life. Early malnutrition can also have a significant impact on cognitive functioning, presumably because of the adverse impact of the malnutrition on the very young brain. In the context of a developmental cascade model, we tested the hypothesis that the association between early malnutrition and adolescent depressive symptoms is mediated by the cognitive impairment that ensues from the malnutrition. Methods: We evaluated Barbadian youth (N = 57) hospitalized for moderate to severe protein-energy malnutrition in the first year of life and healthy controls (N = 60) longitudinally. The primary hypothesis was tested by multiple regression models. Results: After adjusting for covariates, early malnutrition predicted both cognitive functioning in childhood (IQ, p < .001; attention problems, p < .01; Common Entrance Examination, p < .01; and adolescent depressive symptoms, p < .05). Childhood cognitive functioning mediated the association between early malnutrition and depressive symptoms in adolescence (p < .001). Maternal depressive symptoms were a significant but independent predictor of adolescent depressive symptoms (p < .05). Conclusions: Cognitive compromise in childhood accounts indirectly for elevated depressive symptoms in previously malnourished adolescents, consistent with a developmental cascade model. The direct link between malnutrition and depressive symptoms in adolescence is small. Copyright © 2011 Lippincott Williams & Wilkins.


Beardslee W.R.,Harvard University | Beardslee W.R.,Judge Baker Childrens Center | Gladstone T.R.G.,Harvard University | Gladstone T.R.G.,Judge Baker Childrens Center | And 2 more authors.
Journal of the American Academy of Child and Adolescent Psychiatry | Year: 2011

Objective: To provide a conceptual review of the literature on children of depressed parents over the past 12 years. Method: This selective review focused on published studies that delineate the diagnosis of depression in parents, have large samples, describe children 6 to 17 years old, and are methodologically rigorous. The review emphasized conceptual advances and major progress since 1998. Recent efforts in prevention research were discussed, gaps in the existing literature were noted, and directions for targeted research on children of depressed parents were highlighted. Results: Over the past 12 years there has been considerable progress in delineating the gene-by-environment interplay in determining the range of outcomes in children. In addition, progress has been made in identifying risk mechanisms and moderators that underlie the transmission of disorder and in developing effective prevention programs. Conclusions: This review highlights directions for further research, including different areas affected by parental depression in parents and children, and in understanding the underlying mechanisms involved in the intergenerational transmission of depression, so that preventive and treatment efforts can be tailored effectively. © 2011 American Academy of Child and Adolescent Psychiatry.


Zachrisson H.D.,Norwegian Institute of Public Health | Dearing E.,Boston College | Lekhal R.,Norwegian Institute of Public Health | Toppelberg C.O.,Harvard University | Toppelberg C.O.,Judge Baker Childrens Center
Child Development | Year: 2013

Associations between maternal reports of hours in child care and children's externalizing problems at 18 and 36 months of age were examined in a population-based Norwegian sample (n = 75,271). Within a sociopolitical context of homogenously high-quality child care, there was little evidence that high quantity of care causes externalizing problems. Using conventional approaches to handling selection bias and listwise deletion for substantial attrition in this sample, more hours in care predicted higher problem levels, yet with small effect sizes. The finding, however, was not robust to using multiple imputation for missing values. Moreover, when sibling and individual fixed-effects models for handling selection bias were used, no relation between hours and problems was evident. © 2013 Society for Research in Child Development, Inc.


Toppelberg C.O.,Judge Baker Childrens Center | Toppelberg C.O.,Harvard University | Collins B.A.,York College
Child and Adolescent Psychiatric Clinics of North America | Year: 2010

In this article the authors discuss first why it is crucial, from a clinical and public health perspective, to better understand the development as well as risk and protection processes for the mental health of immigrant children. The authors then shift focus to the main tenet of this article, namely, that specific aspects of the dual language development of immigrant children are highly relevant to their mental health and adaptation. This argument is illustrated with empirical studies on Latino immigrant children, as they represent the majority of immigrant children in America and as a way of exemplifying the risks and circumstances that are potentially shared by other immigrant groups. Finally, the authors conceptually differentiate dual language development and its mental health impact from the dual-culture (bicultural) development and circumstance of immigrant children and their mental health impact. © 2010 Elsevier Inc.

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