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Kamble R.R.,Karnatak University | Biradar D.B.,Jubilant Organosys Ltd | Meti G.Y.,Karnatak University | Taj T.,Karnatak University | And 6 more authors.
Journal of Chemical Sciences | Year: 2011

Derivatives of 1,3-thiazolidin-2,4-dione appended to biphenyl ring viz., 7-9, 16-18 were prepared. The newly synthesized compounds were confirmed by IR, NMR (1H and 13(C) MS and elemental analyses. Single crystal X-ray diffraction study was carried out for one of the final compounds 9. © Indian Academy of Sciences.

Saroha K.,Kurukshetra University | Nanda S.,IIT IITD | Yadav N.,Jubilant Organosys Ltd
Pharmaceutical Reviews | Year: 2010

Proniosomal gel is nonionic surfactant based vesicle system which exists in different liquid crystalline phases. Mixing of the surfactant in an alcohol and limited hydration with aqueous phase leads to the formation of proniosomal gel. Due to the limited amount of water present, these systems behave as viscous phases. The various phases of liquid crystalline structures can be utilized as such for topical/transdermal applications or can be used after further hydration to form niosomes. An introduction to the skin structure along with the conversion of proniosomal gel to niosomes is also explained. A review of literature is presented here and a sincere attempt has been made to highlight the properties and characteristics of proniosomes in drugs and cosmetic/cosmeceuticals applications. Interaction studies between proniosome components and skin is also discussed along with the formulation aspects of proniosome gel formulation. Many research papers reports the delivery of therapeutic agents through topical/dermal route, but cosmetic applications were not much explored. Our aim is to introduce and explore proniosome gel as a carrier system for various applications of drugs and cosmeceuticals.

Point and interval hypothesis tests performed to validate two simple and economical, kinetic spectrophotometric methods for the assay of lansoprazole are described. The methods are based on the formation of chelate complex of the drug with Fe(III) and Zn(II). The reaction is followed spectrophotometrically by measuring the rate of change of absorbance of coloured chelates of the drug with Fe(III) and Zn(II) at 445 and 510 nm, respectively. The stoichiometric ratio of lansoprazole to Fe(III) and Zn(II) complexes were found to be 1 : 1 and 2 : 1, respectively. The initial-rate and fixed-time methods are adopted for determination of drug concentrations. The calibration graphs are linear in the range 50-200 μgml -1 (initial-rate method), 20-180 μgml -1 (fixed-time method) for lansoprazole-Fe(III) complex and 120-300 (initial-rate method), and 90-210 μgml -1 (fixed-time method) for lansoprazole-Zn(II) complex. The inter-day and intra-day precision data showed good accuracy and precision of the proposed procedure for analysis of lansoprazole. The point and interval hypothesis tests indicate that the proposed procedures are not biased. Copyright © 2010 John Wiley & Sons, Ltd.

Singh J.,Amrapali Institute of Technology and science | Shukla S.K.,Jubilant Organosys Ltd | Shaik B.,National Institute of Technical Teachers Training and Research | Agrawal V.K.,National Institute of Technical Teachers Training and Research
Oxidation Communications | Year: 2013

Modelling of calcium channel antagonists activity of 1,4-dihydropyridine (DHP) derivatives (41 compounds) was carried out using topological descriptors. A 6-parametric model containing Jhetm, Jhetp, 1χ , 0χv, 2χv and Sz as correlating parameters was found to be the best. The model was tested using cross-validation method.

JUBILANT ORGANOSYS Ltd | Date: 2010-08-06

Disclosed herein are novel polymorphic forms of Fluvastatin sodium, wherein said polymorphic forms are designated as J

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