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Schwaab D.,PGi | Schwaab D.,Ju Lich Aachen Research Alliance Fundamentals of Future Information Technologies JARA FIT | Zentis P.,PGi | Zentis P.,Ju Lich Aachen Research Alliance Fundamentals of Future Information Technologies JARA FIT | And 8 more authors.
Japanese Journal of Applied Physics | Year: 2013

High resolution lithography combined with microcontact printing (CP) by means of polyolefine polymer (POP) stamps enabled to create protein gradient patterns. By this means, discrete purely biochemical gradients of extracellular matrix proteins were fabricated. It was possible to adjust independently both the size of elements of a protein pattern and the distance between them with sub 100nm resolution. Adhesion of primary neurons and directed neuronal outgrowth were observed on these protein patterns. Cellular constituents such as filopodia adhere to different printed protein elements of the discontinuous gradient including features as small as 75 nm. © 2013 The Japan Society of Applied Physics. Source

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