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Grambach, Austria

Bateman R.J.,University of Washington | Aisen P.S.,University of California at San Diego | De Strooper B.,Vlaams Institute for Biotechnology | De Strooper B.,Catholic University of Leuven | And 7 more authors.
Alzheimer's Research and Therapy | Year: 2011

Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention. © 2011 BioMed Central Ltd.

Bolognesi M.L.,University of Bologna | Chiriano G.,International School for Advanced Studies | Bartolini M.,University of Bologna | Mancini F.,University of Bologna | And 10 more authors.
Journal of Medicinal Chemistry | Year: 2011

Eight monomeric congeners, related to the multitarget lead candidate memoquin, were prepared and evaluated at multiple targets to determine their profile against Alzheimer's disease. 2-4 bind to AChE with similar low nanomolar affinities and function as effective inhibitors of amyloid aggregation. The most potent monovalent ligand 2 also inhibits BACE-1 in vitro and APP metabolism in primary chicken telencephalic neurons. (Figure presented) © 2011 American Chemical Society.

Rosini M.,University of Bologna | Simoni E.,University of Bologna | Bartolini M.,University of Bologna | Soriano E.,Institute Quimica Organica General CSIC | And 8 more authors.
ChemMedChem | Year: 2013

Inspired by the concept of bivalent ligands, we prepared a small set of analogues of the drug candidate dimebon. They were shown to inhibit AChE, Aβ42 aggregation, and NMDA receptor activation to a greater extent than dimebon. Some of these compounds also enhanced the survival of chicken neurons under apoptosis-inducing conditions. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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