Leena J.B.,JSS Medical College |
Leena J.B.,Father Muller Medical College |
Vijaya B.,Jssmedical College |
Manjunath G.V.,Jssmedical College |
Journal of Clinical and Diagnostic Research | Year: 2010
Background: The term pemphigus refers to a group of autoimmune blistering diseases of the skin and the mucous membranes. Pemphigus affects 0.1- 0.5 patients per 1,00,000 population per year. Aim: To evaluate the clinical findings in association with histopathological findings, to study the histopathological findings in various vesiculobullous lesions of skin and to confirm with immunofluorescence wherever possible. Materials And Methods: Histopathological evaluation of biopsies received from the department of Dermatology was done in the Department of Pathology, JSS hospital, Mysore, from August 2006 to July 2008. Results: A total number of 648 skin biopsies were received, out of which 22 cases were of the pemphigus group of diseases. Pemphigus vulgaris accounted for 81 %(18) of cases and pemphigus vegetans accounted for 9.01 %(2) of cases. The less common types were pemphigus erythematosus and IgA pemphigus constituting 4.1 %(1) of the cases. Pemphigus vulgaris formed the most common variant. The male to female ratio was 1.35:1. The age incidence was between 21-70 years. The trunk and extremities were the frequently involved sites and had classical flaccid bullae in 90.9% of cases. Oral mucosa was involved in 66% of the cases of pemphigus vulgaris. Apart from the common histopathological changes in pemphigus vulgaris, we also observed: 1.Spongiosis of adjacent epidermis (11 cases) 2. Acantholysis in adnexa (4cases) 3. Hair shaft and sebaceous gland inside bulla (biopsy artifact)(3cases). Both the cases of pemphigus vegetans showed hyperkeratosis, papillomatosis and acanthosis, along with suprabasal bulla containing inflammatory infiltrate. Conclusion; Histopathological features were conclusive in most of the cases of primary vesiculobullous lesions of the skin. The study also revealed additional histopathological findings which are not encountered normally. Analysis of the subtle light microscopic features apart from the classical diagnostic features assisted in the diagnosis of difficult cases. The immunofluorescence study done, helped in confirming the diagnosis where histopathology and clinical features alone were inconclusive.
Srinath C.G.,Jssmedical College |
Rajalakshmi R.,Jssmedical College |
Nataraj S.M.,Jssmedical College
Biomedicine | Year: 2010
Background And Objectives: Obesity is an independent risk factor for cardiovascular diseases. Left ventricular hypertrophy and prolonged QT, QTc interval in ECG are common in obesity. Hence present study was undertaken to assess the Heart rate, QT and QTc intervals response to isometric handgrip exercise test in obese and normal weight subjects. Materials And Methods: 30 obese healthy medical students aged between 18-22 years, with BMI 27.5-32.5kg/m2 formed the study group.30 normal weight healthy medical students aged between 18-22years with BMI 18.5-22.5kg/m2 formed the control group. Baseline ECG was recorded for 5 minutes in lead II using power lab multichannel polygraph instrument. Heart rate.QT and QTc interval were calculated. Both groups were asked to perform isometric exercise at 30% of their maximal voluntary contraction using handgrip dynamometer till the point of fatigue. Lead II ECG was taken immediately after exercise to calculate heart rate, QT and QTc interval. Results: There was a statistically significant prolongation of QT interval in study group when compared to control group before exercise. Heart rate,QT and QTc interval response to isometric hand grip exercise test in study and control group were not statistically significant. Interpretation And Conclusion: There is a positive association between QT, QTc interval and obesity. Otherwise healthy individuals with obesity are at an increased risk for acquiring long QT syndrome and associated malignant ventricular arrhythmias.
Suresh Babu M.,Jssmedical College |
Basavanna Gowdappa H.,Jssmedical College |
Aiyappa M.R.,Jssmedical College |
Sameer S.,Jssmedical College
British Journal of Medical Practitioners | Year: 2011
Thyrotoxic periodic paralysis (TPP) is an alarming and potentially lethal complication of hyperthyroidism characterised by muscle paralysis and hypokalaemia. It is often not recognised when first seen because of lack of familiarity with the disorder and partly due to the subtleness of thyrotoxicosis. Early diagnosis and treatment can prevent severe cardiopulmonary complications. We hereby report a male patient who was evaluated and diagnosed to have TPP.