JSS Hospital

Mysore, India

JSS Hospital

Mysore, India

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Bijanzadeh M.,University of Mysore | Ramachandra N.B.,University of Mysore | Mahesh P.A.,Jss Hospital | Savitha Mysore R.,Cheluvamba Hospital | And 3 more authors.
Lung | Year: 2010

There are more than 100 candidate genes of asthma located on 23 human chromosomes. Interleukin-4 (IL-4), located on chromosome 5q31, and ADAM33, located on chromosome 20p13, and some single nucleotide polymorphisms (SNPs) of these genes have been shown to be associated with asthma and its manifestations in different populations. The most prominent SNPs of IL-4 and ADAM33 are 589C>T and 400A>G, respectively. There are also controversial reports on the association of these SNPs with asthma. In the present study, we analyzed these two SNPs in 100 patients with asthma and 50 controls through PCR amplification and restriction digestion to evaluate association of these two SNPs with asthma. The nonsignificant differences were observed for the IL-4 promoter polymorphism C589T and the ADAM33 T1 polymorphism between asthmatic patients and controls (P = 0.638 and 0.943, respectively). Our data revealed that there is no association of these SNPs with asthma indicating that other SNPs of these genes or other genes might be involved in the manifestation of asthma. © 2010 Springer Science+Business Media, LLC.


Sathvik B.S.,United Arab Emirates University | Karibasappa M.V.,JSS Hospital | Nagavi B.G.,United Arab Emirates University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Introduction: Nonadherence to medications is common in hypertensive subjects. Medication adherence pattern of urban hypertensive population has been widely studied. However, little is known about the medication adherence pattern hypertensive subjects residing in rural settings of India. Objective: This study aimed at assessing the self-reported medication adherence pattern of rural hypertensive patients and to evaluate the impact of pharmacist provided education on self reported adherence pattern. Methodology: Study subjects (n=150) were enrolled from three rural areas of Mysore district, Karnataka, India. The study subjects were block randomized to control group (n=75) and intervention group (n=75). Intervention group received the pharmacist education at baseline, 15th, 30th, 45th day and no medication education was provided to control group subjects. Brief Medication Questionnaire (BMQ), a medication adherence measurement questionnaire was administered to the all the study subjects at baseline and 15 days after the last education session. Results: At baseline there was no significant (P > 0.05) difference between the regimen, belief, recall, and access screen scores of control and intervention group patients. Access screen scores of both control (0.38 ± 0.49) and intervention (0.57 ± 0.50) group documented lowest scores compared to other three screens of BMQ. While scores of regimen screen documented highest, both in control (1.95 ± 0.74) and in intervention (2.23 ± 0.65) group. There was a significant reduction in the regimen (P = 0.04), belief (P = 0.04), recall (P = 0.01), and access (P = 0.04) screen scores of intervention group patients was observed at 60th day of follow-up. But there was no significant (P > 0.05) change/reduction in regimen, belief, recall, and access screen scores of control group patients. Belief (P = 0.03) and recall BMQ screen scores (P = 0.05) of intervention and control group patients at final follow-up. But, there was no significant difference in the regimen (P = 0.09) and access screen scores (P = 0.06) of intervention and control group patients at final-follow-up. Conclusion: Study subjects had some belief and recall barriers towards their antihypertensive medications. Pharmacist provided education was found to be helpful in overcoming these barriers.


Lucca J.M.,JSS University | Ramesh M.,JSS University | Parthasarathi G.,JSS University | Ram D.,JSS Hospital
Journal of Postgraduate Medicine | Year: 2015

Background: In spite of the progress made in the treatment of psychiatric disorders during the last few decades, nonadherence continues to be a frequent phenomenon, often associated with potentially severe clinical consequences and increased health-care costs. There are numerous factors associated with medication nonadherence in patients with mental illness. The aim of the study was to determine the incidence and factors associated with medication nonadherence among psychiatric outpatients. Materials and Methods: A cross-sectional study was carried out in the outpatient psychiatric department of an Indian tertiary care private hospital over a period of 1 year. Patients aged 18 years and above who presented with mental illness as diagnosed by the International Classification of Diseases (ICD)-10 and who were receiving at least one psychotropic medication for at least 1 month were included in the study. Medication adherence was assessed using the Medication Adherence Rating Scale (MARS). Results: Of the 400 patients, 172 (43%) were nonadherent to their prescribed medications. There is a statistically significant association between the education (P = 0.001), number of drugs (P = 0.002), family income (P = 0.013), and nonadherence. Among the 172 patients, 33.5 % were nonadherent to their therapy due to patient-related factors followed by drug-related factors (32%) and disease-related factors (31%). Conclusion: The overall incidence of medication nonadherence in patients with mental illness was 43%. Numerous factors contributed to medication nonadherence. Strategies need to be developed and implemented to enhance medication adherence, and thereby achieve a better therapeutic outcome in patients with mental illness.


Bijanzadeh M.,University of Mysore | Mahesh P.A.,Jss Hospital | Ramachandra N.B.,University of Mysore
Indian Journal of Medical Research | Year: 2011

Asthma is the most common chronic childhood disease in developed nations and its prevalence has increased in the world over the last 25 years. It is a complex disease with both genetic and environmental risk factors. Asthma is caused by multiple interacting genes, some having a protective effect and others contributing to the disease pathogenesis, with each gene having its own tendency to be influenced by the environment. This article reviews the current state of the genetics of asthma in six categories, viz. epidemiology, management, aetiology, family and twin studies, segregation and linkage studies, and candidate genes and single nucleotide polymorphisms (SNPs).


Roy L.G.,University of Mysore | Shetty M.S.,JSS Hospital | Urooj A.,University of Mysore
Journal of Renal Care | Year: 2013

Objective: To formulate a nutrient supplement using low cost, commonly available food ingredients and test its efficacy on various nutritional parameters in haemodialysis (HD) subjects. Design: Prospective intervention study. Subjects: 15 subjects who did not have diabetes were recruited for the study. The subjects served as self controls. Approach: The subjects received a multi-nutrient formulation for a period of 3 months. Somatic status [weight, mid upper arm circumference (MUAC), mid upper arm muscle circumference (MUAMC), waist and hip measurements], biochemical parameters [blood urea nitrogen (BUN), total iron binding capacity (TIBC),serum levels of creatinine, albumin, triglycerides, sodium, potassium, calcium, phosphorus and high sensitive C-reactive protein(HsCRP)], dietary intake and malnutrition inflammation score (MIS) were assessed. Results: Significant increments (P≤0.01) in anthropometric measurements. Significant increases (P≤0.01) in Hb, BUN, serum creatinine, albumin and total protein and a significant decrease (P≤0.01) in HsCRP and MIS were observed at the end of the study. An increase in baseline food/nutrient intake was also observed. Conclusion: Nutritional supplementation designed for haemodialysis, improved their nutritional status in the short term study. © 2013 European Dialysis and Transplant Nurses Association/European Renal Care Association.


Lucca J.M.,JSS University | Ramesh M.,JSS University | Parthasarathi G.,JSS University | Ram D.,JSS Hospital
Indian Journal of Pharmacology | Year: 2014

Diplopia - seeing double - is a symptom with many potential causes, both neurological and ophthalmological. Benzodiazepine induced ocular side-effects are rarely reported. Lorazepam is one of the commonly used benzodiazepine in psychiatric practice. Visual problems associated with administration of lorazepam are rarely reported and the frequency of occurrence is not established. We report a rare case of lorazepam-induced diplopia in a newly diagnosed case of obsessive compulsive disorder.


PubMed | Jss Hospital
Type: Journal Article | Journal: Journal of orthopaedic case reports | Year: 2016

Calcium pyrophosphate crystal deposition disease (CPPD) is the most common form of crystal arthropathy second only to gout. Common clinical presentation is an acute monoarticular arthritis commonly occurring in knee joints. We presented a case of bilateral olecranon bursitis in a calcium pyrophosphate crystal deposition disease.A 42-year-old female patient is presented with golf ball sized painless swellings in the posterior aspect of her elbows. Elbow joints were clinically normal except for restriction of terminal flexion. X-ray showed mild erosion at the tip of olecranon. Excision biopsy of the swelling showed positive birefringent calcium pyrophosphate dehydrate crystals on the inner wall of the specimen on polarized light microscopy.Bilateral olecranon bursitis may be part of the extraarticular manifestations of calcium pyrophosphate dihydrate crystal deposition disease with good prognosis following in toto bursa excision.


PubMed | University of Mysore and JSS Hospital
Type: Journal Article | Journal: Neurological research | Year: 2016

Parkinson disease (PD) is a neurological disease responsible for a considerable rate of mortality and morbidity in the society. Since the symptoms of the disease appear much later than the actual onset of neuron degeneration, a majority of cases remain undiagnosed until the manifestation of the symptoms.In order to investigate the existence of such susceptibility in the population, we analyzed Copy Number Variation (CNV) influences on PD genes in 1715 individuals from 12 different populations.Overall, 16 CNV-PD genes, 3 known to be causal and 13 associated, were found to be significantly enriched. PARK2, was under heavy burden with ~1% of the population containing CNV in the exonic region. The impact of these genes on the genome and disease pathway was analyzed using several genome analysis tools. Protein interaction network of CNV-PD genes revealed a complex interaction of molecules forming a major hub by the -Synuclein, whose direct interactors, LRRK2, PARK2 and ATP13A2 are under CNV influence.We hypothesize that CNVs may not be the initiating event in the pathogenesis of PD and remain latent until additional secondary hits are acquired and also propose novel genes that may fall under the PD pathway which contribute in pathogenesis.


PubMed | JSS Hospital
Type: Journal Article | Journal: Journal of voice : official journal of the Voice Foundation | Year: 2016

The purpose of the present investigation was to understand the spectral differences between individuals with hyperfunctional voice disorders and subjects with normal voice in terms of H1-H2, H1-A1, H1-A2, and H1-A3 (H1, first harmonic amplitude; H2, second harmonic amplitude; A1, amplitude of the most robust harmonic in the region of first formant frequency; A2, amplitude of the strongest harmonic component in the region of second formant frequency; A3, amplitude of the most robust harmonic component in the region of third formant frequency).This study is a standard group comparison.Two groups of subjects were recruited for the study. Group 1 subjects were diagnosed with hyperfunctional voice disorder secondary to either vocal fold nodule, polyps, or edema, and group 2 subjects had clinically normal voice. Voice recordings of all the participants were collected, and their spectrum was analyzed. Further, the amplitudes from the spectrum were investigated, and the vowel harmonic amplitude differences namely H1-H2, H1-A1, H1-A2, and H1-A3 were calculated.The significant effect of groups on all the spectral measures was noted. Individuals with hyperfunctional voice disorders showed a significantly higher amplitude difference, indicating higher spectral noise and breathiness as a result of laryngeal pathology.The present investigation strongly recommends the spectral measures as a quantitative acoustic index of measuring hoarseness. Supplementary researches on this regard would be helpful in differentiating and better quantifying a breathy voice from a modal voice.


PubMed | JSS Hospital
Type: Journal Article | Journal: Journal of orthopaedic case reports | Year: 2017

Simultaneous bilateral fractures of the neck of femur is rare. Hypocalcemia, epilepsy, osteoporosis and electrical injuries are known to cause similar injuries.We report a case of a 43-year-old male who sustained an electrical shock injury following which he fell from a height of around 4 feet. Radiological studies confirmed bilateral transcervical neck of femur fracture. Laboratory investigations revealed the patient had extremely low levels of vitamin D (11.1ng/ml). Patient was treated with three 6.5 mm cannulated cancellous screws on each side. Patient had good functional outcome at the end of one year.We report this case as a rare etiological combination of hypovitaminosis D and electrical injury causing bilateral neck of femur fracture. Such injuries should be diagnosed at the earliest and goal of treatment should be to preserve both the hip joints. Early management would avoid potential complications like non-union and avascular necrosis.

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