JSC International research and production holding Phytochemistry

Karagandy, Kazakhstan

JSC International research and production holding Phytochemistry

Karagandy, Kazakhstan
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Adekenov S.M.,JSC International Research and Production Holding Phytochemistry
Fitoterapia | Year: 2017

The given review provides data on the new sesquiterpene lactones with unusual structure isolated from various natural sources, e.g. fungi, plants, marine growth; about their spread, biological activity, and the presumed biogenetic pathway of their formation. An attempt was made to biologically justify a wide structural formation variety of new sesquiterpene lactones with the unique structure. © 2017 Elsevier B.V.


Adekenova A.S.,JSC International Research and Production Holding Phytochemistry
Eurasian Chemico-Technological Journal | Year: 2016

The aim of this work is the development of effective method for producing the reference standards of Grosheimin and Cynaropicrin for quality control of domestic herbal medicines, as well as project development concerning normative documents on reference standards of Grosheimin and Cynaropicrin, an introduction of reference standards to the Pharmacopoeia of Kazakhstan. This article discusses the method of allocation and purification of reference standards of Grosheimin and Cynaropicrin which are sesquiterpene lactones of guaiane type were obtained from the ethyl acetate extract of Chartolepis intermedia Boiss., using centrifugal distribution chromatography and high performance liquid chromatography, allows to obtain the qualitative target products. The effectiveness of developed technology has reduced the labor contribution in 2.0 times and as a consequence the prime cost of end products come down 3 times. Using of Grosheimin and Cynaropicrin as own reference standard of the Republic of Kazakhstan for monitoring of staged quality control of pharmaceutical production: access control, intermediate control and output control, it means the finished dosage form. There are some chromatographic analysis data of the samples. Such methods as IR and NMR-spectophotometries were applied for determination of molecular structure. Pharmacopoeial methods were used to determine the color, taste, odor and solubility of reference standards in various solvents. Projects for temporary Analytical Normative Documents on reference standards of Grosheimin and Cynaropicrin were developed in accordance with requirement of State Pharmacopeia of the Republic of Kazakhstan. On the basis of obtained results the database for State Pharmacopoeia of the Republic of Kazakhstan will be formed, as well as control over production of new pharmaceuticals from Chartolepis intermedia Boiss. and Saussurea salsa (Pall.) Spreng. © 2016 Al-Farabi Kazakh National University.


Tolokonnikov Y.G.,JSC International research and production holding Phytochemistry
Eurasian Chemico-Technological Journal | Year: 2010

The progressive, ecologically pure technologies of isolation of sesquiterpene γ-lactones of plant origin were examined in this article. The original phytopreparations were developed on their basis. The pharmacoeconomic characteristics of the obtaining of substances of phytopreparations with application of supercritical CO2-extraction and method of preparative centrifugal partition chromatography in comparison with the classical methods of extraction and column chromatography were presented. © 2009 al-Farabi Kazakh National University.


Adekenov S.M.,JSC International Research and Production Holding Phytochemistry
Russian Chemical Bulletin | Year: 2015

Chemical transformations of the sesquiterpene lactone arglabin are reviewed. Approaches to the synthesis of new arglabin derivatives, which are polyfunctional compounds containing hydroxy functions, halogen, phosphorus, and nitrogen atoms, and cyclopropane moieties, are systematically discussed. © 2015 Springer Science+Business Media New York.


Adekenova A.S.,JSC International Research and Production Holding Phytochemistry | Adekenova A.S.,Karaganda State Medical University | Sakenova P.Y.,JSC International Research and Production Holding Phytochemistry | Ivasenko S.A.,Karaganda State Medical University | And 3 more authors.
Chromatographia | Year: 2016

Two sesquiterpene lactones, grosheimin and cynaropicrin, present in the aerial part of the Chartolepis intermedia Boiss. plant can be obtained from the ethyl acetate solid extract of the dried plant. A large-scale purification processing 16 kg of dry plant is presented. The first liquid–liquid extraction step of the 16 kg produced 550 g of dry extract that were divided in two equal portions. A classical low-pressure chromatography method can produce from 275 g of dry extract 13.8 g of grosheimin and 52.3 g of cynaropicrin 95 % pure lactones in 110 h using large amounts of organic solvents and 8 kg of silica gel. Another purification method employing countercurrent chromatography, with a modern hydrostatic column, and reversed phase preparative liquid chromatography were used with the second 275 g dry extract portion. It could produce 17.9 g of 99.4 % pure grosheimin and 68 g of 98.7 % pure cynaropicrin lactones in 95 h, with better yields and minimized losses in chromatographic columns, and using smaller solvent volumes than the classical method. The two purification processes are fully described and compared. © 2015, Springer-Verlag Berlin Heidelberg.


Adekenov S.M.,JSC International Research and Production Holding Phytochemistry | Atazhanova G.A.,JSC International Research and Production Holding Phytochemistry
Eurasian Chemico-Technological Journal | Year: 2013

This review shows the data about isolated heteroatom-containing sesquiterpene lactones from various genera of Asteraceae family, natural occurence, isolation methods and their biological activity. Chlorinecontaining sesquiterpene lactones were isolated from genera of Artemisia L., Achillea L., Acroptilon Cass, Centaurea L., Chartolepis Cass, Eupatorium L., Jurinea Cass, Rhaponticum Adams, Saussurea DC. The greatest quantity of chlorine-containing sesquiterpene lactones were isolated from Centaurea genus. 25 new sesquiterpene lactones with chlorine atom in molecule were isolated and characterized. The sesquiterpene lactones, which in their structure contained a sulphur atom as a component of various alkoxyl-, thiohydroxygroups and acid residues, were isolated from genera of Eupatorium L., Petasites Mill, Helenium L., Acritopappus R.M. King and H. Rob., Arctium L., Saussurea DC. Nitrogen atom in the structure of natural sesquiterpene lactones is present in the form of amino groups as a part of ester groups as well as amino acids as Michael adducts. Nitrogen-containing sesquiterpene lactones were isolated from Acanthospermum Schrank, Saussurea DC. Isolated heteroatom-containing sesquiterpene lactones possess bactericidal, antifungal, cytotoxic, antiviral, virucidal, antiulcer and others activities. Another method for obtaining heteroatom-containing sesquiterpene lactones is a directed synthesis of chlorine-, fluorine-, bromine-, sulphur- and nitrogen-containing sesquiterpene lactones. On the basis of sesquiterpene lactone artemisinin known as an effective antimalarial preparation, we synthesized over 200 derivatives, among which fluorine-, chlorine-, bromine-, nitrogen-, sulphur- and azide-containing derivatives of artemisinin were obtained. © 2013 Al-Farabi Kazakh National University.

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