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Karachi, Pakistan

Zehra K.,DHA Hospital | Mal P.,University of Sindh | Kumar D.,Aga Khan University | Junejo A.M.,JPMC
Journal of the Liaquat University of Medical and Health Sciences | Year: 2014

OBJECTIVE: To determine the frequency of Malnutrition Inflammation Complex Syndrome (MICS) in patients with End Stage kidney disease on maintenance hemodialysis patients presenting to tertiary care Hospital in Karachi. DESIGN: A cross sectional study SETTINGS: Department of Nephrology Jinnah Postgraduate Medical Center, Karachi METHODS: Total of 62 patients was included through non-probability purposive sampling. All patients diagnosed with End stage kidney disease on maintenance hemodialysis (twice week for >3months) were included and patients with acute kidney injury, chronic infections and chronic liver disease were excluded. Malnutrition inflammation score (MIS) was used to determine malnutrition inflammation complex syndrome (MICS). Mean and standard deviation were calculated for continuous variables, and percentages or proportions for categorical variables. Chi square test was used to determine the proportion of MICS in Maintenance Hemodialysis patients. RESULTS: Mean age was 46 years ±12.59 SD (range 18-72 years). 34 (55%) were females and 28 (45%) males. 26 (42%) patients had duration of Maintenance Hemodialysis<1 years and 28(45%) between 1-4 years. Frequency of malnutrition complex syndrome (MICS) in patients with end stage renal failure was noted in 60 (97%) patients, out of these 31(50%) patients had mild MICS and 29 (47%) patients moderate MICS. Mild and Moderate malnutrition complex syndrome (MICS) was more observed in age group of 31-40years (12% in mild and 14% in moderate MCIS).Moderate MICS was higher in females and mild MICS was higher in male patients. CONCLUSION: Our study concluded that most (97%) of our patients with end stage kidney disease on maintenance hemodialysis has evidence of malnutrition inflammation complex syndrome. © 2014, Liaquat University of Medical and Health Sciences. All rights reserved. Source


Dixit S.,Deloitte | Singh M.K.,JPMC
International Conference and Workshop on Emerging Trends in Technology 2011, ICWET 2011 - Conference Proceedings | Year: 2011

Databases and other related concepts are some of the key technologies that power the present IT scenario. Their effect can be felt in all the industries and thus database designing forms a key part in development of any system. In such a scenario coupled with the demanding environment it is imperative that the design is flawless and all the related aspects are well thought of. Such high quality and zero tolerance work require individuals who are highly trained and have complete visibility. Through this paper we present the alternate ways of viewing and visualizing a database in its entirety making use of the thickness of the screen as an additional dimension. One of our prime motives is also to inculcate an additional methodology for imbibing database knowledge among beginners. The alternate view of the conceptual model described in this paper can also be used to find relationships, distinguishing features and other points of interest among database tables, views, warehouses, schemas and transformations. Copyright © 2011 ACM. Source


Sonija M.I.,Government of Pakistan | Mal P.,Health Science University | Kumar D.,Aga Khan University | Junejo A.M.,JPMC
Journal of Pakistan Association of Dermatologists | Year: 2014

Objective: To determine the frequency of cutaneous changes in patients with chronic kidney disease on maintenance hemodialysis. Methods: A cross-sectional study conducted at Department of Nephrology, Jinnah Postgraduate Medical Centre, Karachi from 1st August 2009 to 31st January 2010. A total of 100 patients with chronic kidney disease on maintenance hemodialysis were included. After taking demographic data, cutaneous changes were noted. Mean and standard deviation were computed for quantitative variables (age) and frequency and percentage were computed for categorical variable (sex, cutaneous changes). Results: Mean age was 52.58±13.84 years and out of 100 patients 56% were males. At least one skin change was noted in 91%. Among type of manifestations, xerosis was noted in 96%, generalized xerosis 70%, alopecia 70%, half-and-half nails 36%, scaling 20% and ichthyosis 10%. Pruritus was found in 64%, out of these 93% had mild to moderate intensity and 7% had severe intensity of pruritus. Conclusion: Chronic kidney disease is associated with a complex array of cutaneous manifestations caused either by the disease or by treatment. Xerosis and pruritus were most common among patients with CKD, so early recognition of cutaneous signs can relieve suffering and decrease morbidity. Source


Objective: Psoriasis is a chronic inflammatory skin disease of unknown origin. Different factors might be influencing its course. The aim of our study was to observe and analyze different clinoepidemiological variables of psoriasis in patients reporting to a tertiary care hospital in Karachi. Study Design: Prospective study Place and Duration of Study: This study was conducted at Jinnah Postgraduate Medical Centre, Karachi, Pakistan from January 2014 to December 2014. Materials and Methods: 200 patients (116 Males and 84 females) ages 18 and above with mild to severe psoriasis were selected and assessed on one occasion which included detailed history and examination. All data was documented on completion of study. Results: A total 200 cases were studied. 90% had chronic plaque psoriasis. There was male preponderance with a male to female ratio of 1.38:1. Mean peak age of onset was 11-20 years of age and was earlier in females than males. More than two-third of patients had onset of psoriasis before or at 40 years of age. Familial occurrence was present in 38% of patients and 35% had first degree relative involvement. Psoriatic arthropathy was present in 35% of patients. 86.36% of the patients with arthropathy had onset of psoriasis before 40 years of age. 21% of patients reported worsening of their psoriasis with sun. 32% of the patients in this study were smokers and most of them were males. Conclusion: The findings of this study done in Karachi, Pakistan correlates with previous hospital-based studies done in different parts of the world. Source


Shaikh I.,SMBBMU | Rai P.,SMBBMU | Khoso B.K.,JPMC
Medical Forum Monthly | Year: 2015

Objective: To assess the various ocular manifestations in xeroderma pigmentosum seen at Eye and Dermatology Department of Chandka Medical College Hospital Larkana. Study Design: Prospective study Place and Duration of Study: This study was carried out at two Departments, i.e. at Departments of Dermatology and Ophthalmology of Chandka Medical College larkana from January 2013 to December 2014. Material and methods: Twenty cases were enrolled from outpatient of Eye and Skin Department, Chandka Medical College Hospital Larkana. Patients were subjected to detail history, complete eye and skin examination and relevant investigations. Results: 20 patients, 12(60%) males and 8 (40%) females with xeroderma pigmentosum in a gender ratio of 1.5 : 1 were recruited. All patients had skin freckles and increased sensitivity to sun light. Photophobia and conjunctivitis was seen in 18(90%) cases, keratitis and dry eyes was seen in 12 (60%) cases and 4 (20%) cases had malignancies of lids and conjunctiva proved on biopsy. Our cases belongs to larkana and sukkur division. Conclusion: The present study highlights the eye involvement in xeroderma pigmentosum and thereby early detection of eye disease prevent the malignancies and blindness. Source

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