Muzevic D.,Josip Juraj Strossmayer University of Osijek
The Cochrane database of systematic reviews | Year: 2013
Severe traumatic brain injury is a significant cause of morbidity and mortality. Treatment strategies in management of such injuries are directed to the prevention of secondary brain ischaemia, as a consequence of disturbed post-traumatic cerebral blood flow. They are usually concerned with avoiding high intracranial pressure (ICP) or adequate cerebral perfusion pressure (CPP). An alternative to this conventional treatment is the Lund concept, which emphasises a reduction in microvascular pressures. To assess the role of the Lund concept versus other treatment modalities such as ICP-targeted therapy, CPP-targeted therapy or other possible treatment strategies in the management of severe traumatic brain injury. We searched the Cochrane Injuries Group's Specialised Register, Cochrane Central Register of Controlled Trials (CENTRAL; Issue 10, 2013), MEDLINE (OvidSP), EMBASE (OvidSP), CINAHL Plus (EBSCO Host), ISI Web of Science (SCI-EXPANDED and CPCI-S) and trials registries. We searched the reference lists of relevant studies and published reviews found with our search. The most recent search was 5 November 2013. Randomised controlled trials (RCTs, level 1 evidence) exploring the efficacy of the Lund concept in the treatment of traumatic brain injury. Two review authors independently selected papers and made decisions about the eligibility of potentially relevant studies. We found no studies that met the inclusion criteria for this review. There is no evidence that the Lund concept is a preferable treatment option in the management of severe traumatic brain injury.
Borozan D.,Josip Juraj Strossmayer University of Osijek
Energy Policy | Year: 2013
The main purpose of this paper is to explore the relationship between total energy consumption and real gross domestic product (GDP) covering the period between 1992 and 2010 in Croatia. The methodology employed in this paper is based on the bivariate vector autoregression (VAR) and Granger causality tests. Moreover, the impulse response function and variance decomposition analysis are employed to trace the dynamic response paths of shocks to the system. The empirical analysis shows that, when it is allowed for any deterministic component in the data, total energy consumption and real GDP are not co-integrated in the period observed. Furthermore, there is a unidirectional causality running from total energy consumption to GDP, and an impulse response to GDP caused by energy consumption, being mainly embodied in the first years. The results indicate that total energy consumption is an important component determining economic growth in Croatia and that energy conservation policy should be formulated and implemented wisely. This paper also tests the causality between real GDP and consumption of the five energy variables by using the bivariate VAR. The main implication of these tests is that individual energy forms matter when it comes to energy policy formulation. © 2013 Elsevier Ltd.
Velki M.,Josip Juraj Strossmayer University of Osijek |
Hackenberger B.K.,Josip Juraj Strossmayer University of Osijek
Soil Biology and Biochemistry | Year: 2013
Dimethoate is a broad-spectrum organophosphorous insecticide produced and used in many countries against a wide range of pests. Like other pesticides, dimethoate also affects many non-target organisms, including soil organisms. In this study for the first time effects of dimethoate on molecular biomarkers (AChE, CES, CAT and GST activity, concentration of GSH and efflux pump activity) of Eisenia andrei earthworms were evaluated using the artificial OECD soil. Earthworms were exposed to environmentally relevant doses of dimethoate (0.03, 0.1, 0.3, 1 and 3 mg/kg) for 1, 3, 6, 10, 15, 21 and 28 days and besides the time-related responses of biomarkers, the recovery of AChE, CES and CAT activity was also investigated. Results showed that dimethoate caused dose dependent significant changes in measured biomarkers - inhibition of AChE, CES and CAT activity; increase in GST activity and concentration of GSH; and both induction and inhibition of efflux pump activity. Additionally, the selected molecular biomarkers showed slow recovery rate and at the highest applied concentration of dimethoate, the inhibition of enzymes was evident even after 28 days of recovery. The obtained results indicate that application of dimethoate in agriculture could have harmful effects on earthworms since application of environmentally relevant doses, i.e. doses that are applied in agriculture, caused significant changes in measured biomarkers. © 2012 Elsevier Ltd.
Wagner J.,Josip Juraj Strossmayer University of Osijek
Biochemia Medica | Year: 2012
The existence of cell free DNA in the human circulatory system has been known since the 1950s, however, intensive research in this area has been conducted for the last ten years. This review paper brings a short overview of the existing literature concerning the cell free DNA research in various clinical fields and pathological states and considers the application possibilities of this new analyte in clinical laboratory diagnostics. At the moment, cell free DNA is most widely used for the purpose of non-invasive prenatal diagnosis of fetal sex or fetal RhD status. The recent discovery of epigenetic changes in placental/fetal DNA and the detection of fetal/placental-specific RNAs have made it possible to use this technology in all pregnancies irrespective of the gender of the fetus. With the application of new techniques such as next generation sequencing, digital PCR and mass spectrometry, it is now possible to detect very small amounts of specific DNA in the presence of excess of other nonspecific nucleic acids. Second most probable application is in oncology, where detection and monitoring of tumors is now possible by the detection of tumor-derived nucleic acids. Third promising field for near future implementation of this analyte is transplantation medicine, where free DNA level could serve as a marker of transplant rejection. Before any further utilization of this new biomarker, pre-analytical and analytical aspects of free DNA analysis remain to be standardized. In the field of noninvasive prenatal diagnosis, important ethical, legal and social questions remain to be discussed.
Rastija V.,Josip Juraj Strossmayer University of Osijek
Mini-Reviews in Medicinal Chemistry | Year: 2011
Polyphenols are natural compounds that show a wide spectrum of biological actions potentially beneficial for the human health. Wine is an alcoholic beverage that contains a large amount of polyphenols extracted from grapes during the processes of vinification. These molecules are associated with anticancerogenic, antidiabetic, neuroprotective, hormonal, antimicrobial, cardioprotective, and other health effects of wine. The present review provided an overview of well know and recent achievement in analytical methodology for the analysis of polyphenols in wine, and their biological activities. © 2011 Bentham Science Publishers.
Jakobek L.,Josip Juraj Strossmayer University of Osijek
Food Chemistry | Year: 2015
Polyphenols are secondary metabolites in plants, investigated intensively because of their potential positive effects on human health. Their bioavailability and mechanism of positive effects have been studied, in vitro and in vivo. Lately, a high number of studies takes into account the interactions of polyphenols with compounds present in foods, like carbohydrates, proteins or lipids, because these food constituents can have significant effects on the activity of phenolic compounds. This paper reviews the interactions between phenolic compounds and lipids, carbohydrates and proteins and their impact on polyphenol activity. © 2014 Elsevier Ltd.
Sabo K.,Josip Juraj Strossmayer University of Osijek
International Journal of Applied Mathematics and Computer Science | Year: 2014
In this paper, we consider the l1-clustering problem for a finite data-point set which should be partitioned into k disjoint nonempty subsets. In that case, the objective function does not have to be either convex or differentiable, and generally it may have many local or global minima. Therefore, it becomes a complex global optimization problem. A method of searching for a locally optimal solution is proposed in the paper, the convergence of the corresponding iterative process is proved and the corresponding algorithm is given. The method is illustrated by and compared with some other clustering methods, especially with the l2-clustering method, which is also known in the literature as a smooth k-means method, on a few typical situations, such as the presence of outliers among the data and the clustering of incomplete data. Numerical experiments show in this case that the proposed l1-clustering algorithm is faster and gives significantly better results than the l2-clustering algorithm.
Mihaljevic M.,Josip Juraj Strossmayer University of Osijek
Fundamental and Applied Limnology | Year: 2012
The colonization process of periphyton algae was studied in the Danubian floodplain (Lake Sakadaš, Nature Park Kopački Rit, Croatia) under variable spring hydrological conditions. We used an in situ experiment, with artificial substrata, to examine changes in the algal community composition during the early phase of periphyton formation. A few flood pulses characterized the hydrological conditions during the period of investigation (April- May, 2010) and altered the physical and chemical environment of the lake. The periphyton formation was initiated very early, on the first day of deployment, due to the rapid formation of bacterial biofilm. Total periphyton biomass continuously increased during the colonization period with changes in the trophic nature from the prevalence of organic matter to the prevalence of inorganic matter after day 15. The composition of periphyton algal assemblages and abundance changed gradually during the colonization period and the following sequences can be defined: the initial phase (days 1- 9, dominated by planktonic cyanobacteria and horizontally positioned diatoms), the intermediate phase (days 12 -18 characterised by stalk-forming diatoms (Gomphonema and Cymbella)) and the late phase (days 21- 42 dominated by vertically positioned diatoms (Nitzschia)). This sequence of algal colonization is similar to that found in other freshwater habitats. Achnanthidium minutissimum was particularly abundant in the late phase of colonisation which was characterised by flooding and indicated natural disturbance. © 2012 E. Schweizerbart'sche Verlagsbuchhandlung, Stuttgart, Germany.
Palijan G.,Josip Juraj Strossmayer University of Osijek
Microbial Ecology | Year: 2012
This study investigated the relationships of time-dependent hydrological variability and selected microbial food web components. Samples were collected monthly from the Kopački Rit floodplain in Croatia, over a period of 19 months, for analysis of bacterioplankton abundance, cell size and biomass; abundance of heterotrophic nanoflagellates and nanophytoplankton; and concentration of chlorophyll a. Similar hydrological variability at different times of the year enabled partition of seasonal effects from hydrological changes on microbial community properties. The results suggested that, unlike some other studies investigating sites with different connectivity, bacterioplankton abundance, and phytoplankton abundance and biomass increased during lentic conditions. At increasing water level, nanophytoplankton showed lower sensitivity to disturbance in comparison with total phytoplankton biomass: this could prolong autotrophic conditions within the floodplain. Bacterioplankton biomass, unlike phytoplankton, was not impacted by hydrology. The bacterial biomass less affected by hydrological changes can be an important additional food component for the floodplain food web. The results also suggested a mechanism controlling bacterial cell size independent of hydrology, as bacterial cell size was significantly decreased as nanoflagellate abundance increased. Hydrology, regardless of seasonal sucession, has the potential to structure microbial food webs, supporting microbial development during lentic conditions. Conversely, other components appear unaffected by hydrology or may be more strongly controlled by biotic interactions. This research, therefore, adds to understanding on microbial food web interactions in the context of flood and flow pulses in river-floodplain ecosystems. © 2012 Springer Science+Business Media, LLC.
Bill and Josip Juraj Strossmayer University of Osijek | Date: 2014-08-27
The present invention is directed to a pharmaceutical composition or a kit-of-parts and its use in the treatment of burnout syndrome and longevity therapy.