Grenoble, France

Joseph Fourier University

www.ujf-grenoble.fr
Grenoble, France

Université Joseph Fourier , often known as UJF, is a French university situated in the city of Grenoble and focused on the fields of science, technologies and health. This institution was previously also called Université Grenoble I . Wikipedia.

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A method for the automated manufacture of an electronic circuit tolerant to faults by temporal redundancy of maximum order N, comprising a step implemented by computer, which involves replacing any memory cell of the circuit with a memory block (40) comprising a chain of memory cells in series, and a selection block which selects, in a temporal redundancy mode of order n1, n1 [1,N], as output data of the memory block, the majority content of n1 cells of the block, and can further deliver a fault signal if the content of the n1 cells differs. Said method is characterised in that the inserted memory blocks allow dynamic switching from a temporal redundancy mode of order n1 to any other mode of order n2. Said method for N=2, in association with a recording mechanism with backward recovery, makes it possible to mask an error with only double redundancy instead of triple redundancy.


Patent
Diagnostica Stago, French National Center for Scientific Research and Joseph Fourier University | Date: 2017-06-14

The present invention relates to a method for dynamically determining the structural profile of a fibrin clot, reflecting the stability thereof in a biological sample of a patient, said method comprising the following steps: a) mixing the undiluted biological sample with tissue factor or a mixture of tissue factor and tissue plasminogen activator; b) incubating the mixture obtained in step a), then adding calcium ions to the mixture obtained, in order to initiate the formation of a fibrin clot; c) measuring the turbidity or the optical density of the clot being formed in step b), at at least two wavelengths of between 450 nm and 850 nm, and for a time of between 1 and 35 minutes; d) determining the structural profile of the analysed clot, expressed as a number of protofibrils, density and radius in c) by means of the formula .5 = A [Fg].(2 - B), wherein is the turbidity of the clot at a given wavelength , [Fg] is the initial weight concentration of fibrinogen, and A and B are coefficients which are proportional, respectively, to the density and the radius of the fibres that make up the clot; and e) comparing the obtained profile with a control. The method preferably includes a step f) that makes it possible to predict the risk of bleeding, thrombosis or rethrombosis and to select the anticoagulant that is best suited to the clinical situation of a patient.


A method and device for detecting a worsening of the cardio-respiratory condition of a patient treated using a respiratory assistance device comprising means for collecting and processing parameters indicative: - of a first parameter indicative of the breathing rate in a first observation window; - of a second parameter indicative of the percentage of cycles initiated by the patient during a second observation window; - of a third parameter indicative of the duration of use of the apparatus during a third observation window. The method is characterized in that it involves detecting a significant variation in one of said parameters over at least two consecutive or non-consecutive days during a consecutive period of n days, where n is strictly greater than 3 and preferably greater than or equal to 5; and, in response to said detection, generating an alert intended for said patient or for a practitioner in order to inform same of a significant risk of worsening of the cardio-respiratory condition of the patient.


The invention relates to a method of processing a biological signal including peaks, said biological signal being recorded by at least one sensor, the method comprising:


Patent
Joseph Fourier University and French National Center for Scientific Research | Date: 2015-04-22

The present invention relates to novel NADPH oxidase, or Nox, proteins, to the use thereof, to a method for preparing same and to a method for identifying same.


Patent
French National Center for Scientific Research and Joseph Fourier University | Date: 2015-02-26

Multimenic lectins having a -propeller architecture, formed from monomer modules of approximately 30 to 60 amino acids, in which the binding sites to the glycans are situated on a given side of the proteins and the O-terminus and N-terminus ends of the peptide chains on the other side of the proteins, characterized in that they are formed from 4 to 7 monomer modules, a single, or a plurality of, or all of the adjacent modules being linked to one another by the linkers linking the N-terminus end of one module to the C-terminus end of the adjacent module.


Patent
University Grenobles Alpes and Joseph Fourier University | Date: 2017-01-03

A process for obtaining an adapted strain of Pseudomonas includes the following steps: deleting the genes ExoS, ExoT, aroA and lasl in an initial Pseudomonas strain cultivated in a LB medium; progressively cultivating this strain in a chemically defined medium based on a glucose minimal medium supplemented with magnesium and calcium; wherein the adapted strain presents the same toxicity and secretion capacities than the initial strain, and its doubling time when cultivated in the chemically defined medium is less than 60 minutes. An adapted strain is furthermore treated to become killed but metabolically active.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-09-2015 | Award Amount: 28.14M | Year: 2016

Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the European HIV Vaccine Alliance (EHVA) program will develop a Multidisciplinary Vaccine Platform (MVP) in the fields of prophylactic and therapeutic HIV vaccines. The Specific Objectives of the MVP are to build up: 1.Discovery Platform with the goal of generating novel vaccine candidates inducing potent neutralizing and non-neutralizing antibody responses and T-cell responses, 2. Immune Profiling Platform with the goal of ranking novel and existing (benchmark) vaccine candidates on the basis of the immune profile, 3. Data Management/Integration/Down-Selection Platform, with the goal of providing statistical tools for the analysis and interpretation of complex data and algorithms for the efficient selection of vaccines, and 4. Clinical Trials Platform with the goal of accelerating the clinical development of novel vaccines and the early prediction of vaccine failure. EHVA project has developed a global and innovative strategy which includes: a) the multidisciplinary expertise involving immunologists, virologists, structural biology experts, statisticians and computational scientists and clinicians; b) the most innovative technologies to profile immune response and virus reservoir; c) the access to large cohort studies bringing together top European clinical scientists/centres in the fields of prophylactic and therapeutic vaccines, d) the access to a panel of experimental HIV vaccines under clinical development that will be used as benchmark, and e) the liaison to a number of African leading scientists/programs which will foster the testing of future EHVA vaccines through EDCTP


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETPROACT-01-2016 | Award Amount: 8.65M | Year: 2016

The goal of BrainCom is to develop a new generation of neuroprosthetic devices for large-scale and high density recording and stimulation of the human cortex, suitable to explore and repair high-level cognitive functions. Since one of the most invalidating neurospychological conditions is arguably the impossibility to communicate with others, BrainCom primarily focuses on the restoration of speech and communication in aphasic patients suffering from upper spinal cord, brainstem or brain damage. To target broadly distributed neural systems as the language network, BrainCom proposes to use novel electronic technologies based on nanomaterials to design ultra-flexible cortical and intracortical implants adapted to large-scale high-density recording and stimulation. The main challenge of the project is to achieve flexible contact of broad cortical areas for stimulation and neural activity decoding with unprecedented spatial and temporal resolution. Critically, the development of such novel neuroprosthetic devices will permit significant advances to the basic understanding of the dynamics and neural information processing in cortical speech networks and the development of speech rehabilitation solutions using innovative brain-computer interfaces. Beyond this application, BrainCom innovations will enable the study and repair of other high-level cognitive functions such as learning and memory as well as other clinical applications such as epilepsy monitoring using closed-loop paradigms. BrainCom will be carried out by a consortium assembled to foster the emergence of a new community in Europe acting towards the development of neural speech prostheses. Thanks to its high interdisciplinarity involving technology, engineering, biology, clinical sciences, and ethics, BrainCom will contribute advances to all levels of the value chain: from technology and engineering to basic and language neuroscience, and from preclinical research in animals to clinical studies in humans.


De Pape G.,Joseph Fourier University
Annual Review of Physical Chemistry | Year: 2012

Solid-state nuclear magnetic resonance (SSNMR) magic angle spinning (MAS) can be used to record high-resolution data dominated by site-specific information. Although MAS introduces high resolution by attenuating the anisotropic broadening, it also suppresses the nuclear dipole-dipole distance information that is the source of most structural data in the spectra. Such information can be reintroduced coherently and thus selectively by the application of a carefully chosen sequence of radiofrequency pulses, an approach that was introduced 20 years ago and is referred to as dipolar recoupling. This review presents the establishment of recoupling techniques in SSNMR and recalls the major steps achieved by the community throughout the last two decades. This review also presents emerging techniques and their corresponding new concepts. Finally, we present some recent developments based on second-order recoupling mechanisms and discuss their implications regarding dipolar truncation and the possibility to extract structural constraints in uniformly labeled systems. © Copyright ©2012 by Annual Reviews. All rights reserved.

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