Eftaiha A.F.,Suwagh Company for Drug Delivery Systems |
Qinna N.,Suwagh Company for Drug Delivery Systems |
Qinna N.,University of Petra |
Rashid I.S.,Suwagh Company for Drug Delivery Systems |
And 4 more authors.
Marine Drugs | Year: 2010
Metronidazole, a common antibacterial drug, was incorporated into a hydrophilic polymer matrix composed of chitosan xanthan gum mixture. Hydrogel formation of this binary chitosan-xanthan gum combination was tested for its ability to control the release of metronidazole as a drug model. This preparation (MZ-CR) was characterized by in vitro, ex vivo bioadhesion and in vivo bioavailability study. For comparison purposes a commercial extended release formulation of metronidazole (CMZ) was used as a reference. The in vitro drug-release profiles of metronidazole preparation and CMZ were similar in 0.1 M HCl and phosphate buffer pH 6.8. Moreover, metronidazole preparation and CMZ showed a similar detachment force to sheep stomach mucosa, while the bioadhesion of the metronidazole preparation was higher three times than CMZ to sheep duodenum. The results of in vivo study indicated that the absorption of metronidazole from the preparation was faster than that of CMZ. Also, MZ-CR leads to higher metronidazole Cmax and AUC relative to that of the CMZ. This increase in bioavailability might be explained by the bioadhesion of the preparation at the upper part of the small intestine that could result in an increase in the overall intestinal transit time. As a conclusion, formulating chitosan-xanthan gum mixture as a hydrophilic polymer matrix resulted in a superior pharmacokinetic parameters translated by better rate and extent of absorption of metronidazole. © 2010 by the authors; licensee MDPI.
Ibrahim K.A.,Al - Hussein Bin Talal University |
Ibrahim K.A.,King Saud University |
El-Eswed B.I.,Al - Balqa Applied University |
Abu-Sbeih K.A.,Al - Hussein Bin Talal University |
And 4 more authors.
Marine Drugs | Year: 2016
An increasing interest has recently been shown to use chitin/chitosan oligomers (chito-oligomers) in medicine and food fields because they are not only water-soluble, nontoxic, and biocompatible materials, but they also exhibit numerous biological properties, including antibacterial, antifungal, and antitumor activities, as well as immuno-enhancing effects on animals. Conventional depolymerization methods of chitosan to chito-oligomers are either chemical by acid-hydrolysis under harsh conditions or by enzymatic degradation. In this work, hydrolysis of chitosan to chito-oligomers has been achieved by applying adsorption-separation technique using diluted HCl in the presence of different types of zeolite as adsorbents. The chito-oligomers were retrieved from adsorbents and characterized by differential scanning calorimetry (DSC), liquid chromatography/mass spectroscopy (LC/MS), and ninhydrin test. © 2016 by the authors; licensee MDPI.
Rashid I.,Jordanian Pharmaceutical Manufacturing Co. |
Al Omari M.M.H.,Jordanian Pharmaceutical Manufacturing Co. |
Badwan A.A.,Jordanian Pharmaceutical Manufacturing Co.
Starch/Staerke | Year: 2013
The development of new materials, processes and in machinery plays an important role in pharmaceutical industry. This allows the solid dosage form manufacturers to improve and develop their processes toward the exploitation of direct compression and dry granulation (e.g., roll compaction) leading to relatively fast process and low cost. This review outlines a comprehensive understanding on the physico-chemical and compaction properties of native and modified starches. The physical modification of native starch has been given a technical focus along with an understanding on the impact of their modified powder/tablet properties on direct compression attributes. All processes involved on starch modifications have been confined herein to the production of direct compression excipients with multifunctional purposes as most chemical modifications exhibit limited applications. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Athamneh N.A.,Jordan University of Science and Technology |
Tashtoush B.M.,Jordan University of Science and Technology |
Qandil A.M.,Jordan University of Science and Technology |
Al-Tanni B.M.,Jordan University of Science and Technology |
And 6 more authors.
Drug Development and Industrial Pharmacy | Year: 2013
A complex of low molecular weight chitosan (LMWC) with oleic acid and diclofenac potassium (DP) was prepared and dispersed in high concentrations of polysorbate 20, 60 and 80 in water to form a solution which releases its components slowly. The formed complex was characterized using different analytical methods. The size of the resulted nanoparticles and the effect of tweens on size were followed using dynamic light scattering (DLS). The release of DP from this delivery system was monitored by altering the molecular weight of chitosan and the type and concentration of the polysorbates used. The most suitable preparation consisted of DP, LMWC 13kDa, and oleic acid. This was dispersed in 5% Tween 80 and the release was followed by the adaptation of USP II apparatus using a cellophane bag. This preparation offers a release of up to 24h. © 2013 Informa Healthcare USA, Inc.
Al Omari M.M.,Jordanian Pharmaceutical Manufacturing Company |
El-Barghouthi M.I.,Hashemite University |
Zughul M.B.,University of Jordan |
Davies J.E.D.,Lancaster University |
Badwan A.A.,Jordanian Pharmaceutical Manufacturing Company
Journal of Molecular Liquids | Year: 2010
A measurement of the hydrophobic character of the drug substrate, henceforward termed as the hydrophobic effect (HE), to complex stability is established through the observed linear correlation of the free energy of 1:1 complex formation (ΔGK11 = - RTlnK11 x) with the free energy of inherent drug solubility (ΔG So = - RTlnSo x). Estimates of HE contribution (the magnitude of the slope) to 1:1 drug/β-cyclodextrin (β-CD) complex stability vary from 6% for dipyridamole (Dipy), ∼ 37% for cispapride (Cisp) and sildenafil (Sild), ∼ 55% for astemizole (Astm) and terfinadine (Terf), ∼ 65% for pizotifen (Pizo) and loratidine (Lort), 71% for ketotifen (Keto) and 77% for risperidone (Risp), fexofenadine (Fexo) and celecoxib (Celox). Thus HE varies with the structure of drug species. In contrast, the contribution of structural factors (SF) also varies but in an opposite manner, with no apparent consistent trend. For example, SF is relatively high for Dipy (- 25 kJ/mol) and low for Astm, Risp and Celox (∼-5 kJ/mol). Results indicate that HE is not the sole driving force for complex stability. Therefore, any theoretical approach used to predict a quantitative structure activity relationship (QSAR) must consider the three-dimensional structures of drug-cyclodextrin interacting molecules. © 2010 Elsevier B.V. All rights reserved.
Rashid I.,Jordanian Pharmaceutical Manufacturing Co. |
Al Omari M.H.,Jordanian Pharmaceutical Manufacturing Co. |
Leharne S.A.,University of Greenwich |
Chowdhry B.Z.,University of Greenwich |
Badwan A.,Jordanian Pharmaceutical Manufacturing Co.
Starch/Staerke | Year: 2012
The chemical and physical modifications of native maize starch subjected to treatment with aqueous Na silicate have been investigated. The application of FTIR, DSC, XRPD, and NMR analysis is discussed herein with respect to the interaction of Na silicate with starch in relation to gelatinization. XRPD results indicate that Na silicate, in the ionized form, disrupts the molecular structure of starch in a manner similar to thermally induced starch gelatinization. In addition, Na silicate forms new C=O-O-SiO2Na moieties with the amylopectin starch component. This was ascertained by the detection of the in-plane vibration of the -Si-O as a distinctive FTIR band at 580-600 cm-1 and the appearance of a new carboxyl group (-COOH) NMR chemical shift at 168 ppm for the amylopectin/Na silicate system. DSC analysis showed two adjacent endothermic transitions at 192 and 198°C for starch/amylopectin treated with Na silicate whereas amylose treated with Na silicate did not show any new endothermic/or exothermic transitions. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.