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Athamneh N.A.,Jordan University of Science and Technology | Tashtoush B.M.,Jordan University of Science and Technology | Qandil A.M.,Jordan University of Science and Technology | Al-Tanni B.M.,Jordan University of Science and Technology | And 6 more authors.
Drug Development and Industrial Pharmacy | Year: 2013

A complex of low molecular weight chitosan (LMWC) with oleic acid and diclofenac potassium (DP) was prepared and dispersed in high concentrations of polysorbate 20, 60 and 80 in water to form a solution which releases its components slowly. The formed complex was characterized using different analytical methods. The size of the resulted nanoparticles and the effect of tweens on size were followed using dynamic light scattering (DLS). The release of DP from this delivery system was monitored by altering the molecular weight of chitosan and the type and concentration of the polysorbates used. The most suitable preparation consisted of DP, LMWC 13kDa, and oleic acid. This was dispersed in 5% Tween 80 and the release was followed by the adaptation of USP II apparatus using a cellophane bag. This preparation offers a release of up to 24h. © 2013 Informa Healthcare USA, Inc.


Rashid I.,Jordanian Pharmaceutical Manufacturing Co. | Al Omari M.H.,Jordanian Pharmaceutical Manufacturing Co. | Leharne S.A.,University of Greenwich | Chowdhry B.Z.,University of Greenwich | Badwan A.,Jordanian Pharmaceutical Manufacturing Co.
Starch/Staerke | Year: 2012

The chemical and physical modifications of native maize starch subjected to treatment with aqueous Na silicate have been investigated. The application of FTIR, DSC, XRPD, and NMR analysis is discussed herein with respect to the interaction of Na silicate with starch in relation to gelatinization. XRPD results indicate that Na silicate, in the ionized form, disrupts the molecular structure of starch in a manner similar to thermally induced starch gelatinization. In addition, Na silicate forms new C=O-O-SiO2Na moieties with the amylopectin starch component. This was ascertained by the detection of the in-plane vibration of the -Si-O as a distinctive FTIR band at 580-600 cm-1 and the appearance of a new carboxyl group (-COOH) NMR chemical shift at 168 ppm for the amylopectin/Na silicate system. DSC analysis showed two adjacent endothermic transitions at 192 and 198°C for starch/amylopectin treated with Na silicate whereas amylose treated with Na silicate did not show any new endothermic/or exothermic transitions. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Rashid I.,Jordanian Pharmaceutical Manufacturing Co. | Al Omari M.M.H.,Jordanian Pharmaceutical Manufacturing Co. | Badwan A.A.,Jordanian Pharmaceutical Manufacturing Co.
Starch/Staerke | Year: 2013

The development of new materials, processes and in machinery plays an important role in pharmaceutical industry. This allows the solid dosage form manufacturers to improve and develop their processes toward the exploitation of direct compression and dry granulation (e.g., roll compaction) leading to relatively fast process and low cost. This review outlines a comprehensive understanding on the physico-chemical and compaction properties of native and modified starches. The physical modification of native starch has been given a technical focus along with an understanding on the impact of their modified powder/tablet properties on direct compression attributes. All processes involved on starch modifications have been confined herein to the production of direct compression excipients with multifunctional purposes as most chemical modifications exhibit limited applications. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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