Kim L.-H.,Chonbuk National University |
Shin J.-A.,Baylor College of Medicine |
Jang B.,Chonbuk National University |
Yang I.-H.,Chonbuk National University |
And 5 more authors.
Archives of Oral Biology | Year: 2017
Objective The mimetic BH3 ABT-737, a potent inhibitor of anti-apoptotic Bcl-2 family proteins, has potential as anti-cancer drug in many cancers. Recently, patients treated with ABT-737 have developed drug tolerance during cancer therapy. Therefore, we examined whether ABT-737 is effective in killing MC-3 and HSC-3 human oral cancer cells either alone or in combination with the oncogenic kinase inhibitor, sorafenib. Design The potentiating activities of sorafenib in ABT-737-induced apoptosis were determined using trypan blue exclusion assay, DAPI staining, cell viability assay and Western blot analysis. Results Combined use of ABT-737 and sorafenib synergistically suppressed cell viability and induced apoptosis compared with either compound individually. The combination of ABT-737 and sorafenib altered only Bax and Bak proteins and their activations, resulting in mitochondrial translocation of Bax from the cytosol. Additionally, combination treatment-mediated apoptosis may be correlated with ERK and STAT3 pathways. Conclusions These results suggest that sorafenib may effectively overcome ABT-737 resistance to apoptotic cell death, which can be a new potential chemotherapeutic strategy against human oral cancer. © 2016 Elsevier Ltd
Jung E.,Soonchunhyang University |
Jung E.,Myongji University |
Hyun W.,Joongbu UniversityChungnam |
Ro Y.,Columbia University |
And 2 more authors.
Nutrition Research and Practice | Year: 2016
BACKGROUND/OBJECTIVES: College students are in a period of transition from adolescence to adulthood, in which proper dietary habits and balanced nutritional intake are very important. However, improper dietary habits and lifestyles can bring several health problems. This study was performed to investigate blood lipid profiles, blood aluminum and mercury in college students and the relationships among them. SUBJECTS/METHODS: The subjects were 80 college students (43 males and 37 females) in Gyeonggi-do. General characteristics, anthropometric measurements, blood pressure, blood lipids, SGOT, SGPT, and blood aluminum and mercury of the subjects were measured and analyzed, and their relationship was studied. RESULTS: The BMI was significantly higher in males, 23.69 ± 3.20 kg/m2, than in females, 20.38 ± 2.37 kg/m2 (P < 0.001). The blood pressure was significantly higher in males with 128.93 ± 12.92 mmHg systolic pressure and 77.14 ± 10.31 mmHg diastolic pressure compared to females with 109.78 ± 11.97 mmHg and 65.95 ± 6.92 mmHg, respectively (P < 0.001). HDL cholesterol in males, 61.88 ± 13.06 mg/dl, was lower than 64.73 ± 12.16 mg/dl in females, but other blood lipid levels were higher in males. Blood aluminum was significantly higher in males, 9.12 ± 2.11 µg/L, than in females, 8.03 ± 2.14 µg/L (P < 0.05), and blood mercury was higher in males, 3.08 ± 1.55 µg/L, than in females, 2.64 ± 1.49 µg/L. The blood lipids showed positive correlation with obesity and blood pressure. CONCLUSIONS: The degree of obesity, blood pressure, triglycerides, and LDL cholesterol were higher in males, suggesting possible association with chronic disease incidence such as hyperlipidemia and hypertension. Thus, it is considered that a systematic health education is needed for college students, especially for males. © 2016 The Korean Nutrition Society and the Korean Society of Community Nutrition.
Lee H.W.,Korea Institute of Oriental Medicine |
Jun J.H.,Korea Institute of Oriental Medicine |
Kil K.-J.,Joongbu UniversityChungNam |
Ko B.-S.,Korea Institute of Oriental Medicine |
And 2 more authors.
Maturitas | Year: 2016
Danggui Shaoyao San (DSS), a traditional herbal prescription, has long been used to treat menopause-related symptoms, including dysmenorrhea. We conducted a systematic review of randomized controlled trials to evaluate the efficacy of DSS for dysmenorrhea. We searched the following electronic databases through October 2015: PubMed; EMBASE; the Cochrane Library; AMED; five Korean databases (KoreaMed, DBPIA, OASIS, RISS, and KISS); three Chinese databases (CNKI, Wan Fang Database, and VIP), and one Japanese database (CiNii). The Cochrane criteria were used to assess the risk of bias for the individual studies. All randomized clinical trials (RCTs) of DSS or modified DSS were included. Data from all articles were extracted by two independent reviewers. Meta-analysis was used to pool the data. A total of 746 potentially relevant studies were identified, and four RCTs met our inclusion criteria. All of the included RCTs had a high risk of bias across their domains. Three RCTs showed favourable effects of DSS on response rate compared with conventional medicine, and a meta-analysis showed that DSS had superior effects compared to analgesics (RR: 1.31, 95%CI, 1.06-1.63, I2 = 73%). One RCT showed a beneficial effect of DSS on pain compared with placebo control. Our systematic review and meta-analysis provided suggestive evidence of the superiority of DSS over analgesics or placebo for dysmenorrhea. The quality of evidence for this finding was low to moderate because of a high risk of bias. © 2015 Elsevier Ireland Ltd. All rights reserved.
Kang Y.J.,Joongbu UniversityChungnam |
Kang S.H.,Joongbu UniversityChungnam |
Shin S.W.,Joongbu UniversityChungnam |
Lee Y.H.,Joongbu UniversityChungnam
Advanced Science Letters | Year: 2015
The purpose of this study is to present a method of utilizing internet science sites as a teaching tool and what needs to be complemented and improved in the field of early childhood education. 85 internet science sites were divided into three operational areas: teaching, teaching-learning and teaching environment. Also, the adequacy of site configurations was analyzed. As a result of utilizing the internet sites as a teaching medium for young children, they were analyzed to be inadequate in all three areas. Therefore, internet usage for young children should be developed in accordance with the infant’s interest and development. © 2015, American Scientific Publishers. All rights reserved.
Kwon Y.-S.,Joongbu UniversityChungnam
International Journal of Applied Engineering Research | Year: 2014
Background: Many students have difficulty adjusting to college, and diverse factors are related with students’ maladaptation to college. Objective: The purposes of this study were to examine relationship among stress, depression, social support, self-esteem and adjustment to college life, and find factors related with adjustment to college. Results: Stress and depression were negatively related to college adjustment. Social support and self-esteem were positively related to college adjustment. Hierarchical multiple regression analyses indicated that stress (ß=−.414, p<.001), depression (ß=−.276, p<.001) and selfesteem (ß=.167, p<.01) were identified as significant predictors of adjustment to college, after adjusting for age, gender, economic status. Conclusion: These findings support the importance of establishing intervention strategies designed to decrease stress and depression of students to help them well adjust to school life. © Research India Publications.