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Solhi L.,Iran Polymer And Petrochemical Institute | Atai M.,Iran Polymer And Petrochemical Institute | Nodehi A.,Iran Polymer And Petrochemical Institute | Imani M.,Iran Polymer And Petrochemical Institute | And 2 more authors.
Dental Materials | Year: 2012

Objective: This work investigates the graft polymerization of acrylic acid onto nanoclay platelets to be utilized as reinforcing fillers in an experimental dental adhesive. Physical and mechanical properties of the adhesive and its shear bond strength to dentin are studied. The effect of the modification on the stability of the nanoparticle dispersion in the dilute adhesive is also investigated. Materials and methods: Poly(acrylic acid) (PAA) was grafted onto the pristine Na-MMT nanoclay (Cloisite ® Na +) through the free radical polymerization of acylic acid in an aqueous media. The resulting PAA-g-nanoclay was characterized using FTIR, TGA and X-ray diffraction (XRD). The modified nanoclays were added to an experimental dental adhesive in different concentrations and the morphology of the nanoclay layers in the photocured adhesive matrix was studied using TEM and XRD. Shear bond strength of the adhesives containing different filler contents was tested on the human premolar teeth. The stability of nanoclay dispersion in the dilute adhesive was also studied using a separation analyzer. The results were then statistically analyzed and compared. Results: The results confirmed the grafting reaction and revealed a partially exfoliated structure for the PAA-g-nanoclay. Incorporation of 0.2 wt.% of the modified nanoclay into the experimental adhesive provided higher shear bond strength. The dispersion stability of the modified nanoparticles in the dilute adhesive was also enhanced more than 25 times. Significance: Incorporation of the modified particles as reinforcing fillers into the adhesive resulted in higher mechanical properties. The nanofiller containing bonding agent also showed higher shear bond strength due to the probable interaction of the carboxylic acid functional groups on the surface of the modified particles with hydroxyapatite of dentin. © 2011 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved. Source

Ebrahimi A.,Kermanshah University of Medical Sciences | Radmanesh M.,Jondishapour University of Medical science
Journal of Dermatological Treatment | Year: 2010

Background: The treatment of multiple eccrine hydrocystomas is challenging. Surgical excision is impractical. The outcomes of CO2 and pulsed-dye laser therapy are not well studied. Botulinum toxin-A (BT-A) can block the secretions of the sweat glands and prevent dilatation of the cysts. Objective: To study the efficacy of BT-A on eccrine hydrocystoma. Methods: Eighteen patients with multiple facial eccrine hydrocystomas were treated by BT-A. The 500 IU vial of BT-A (Dysport; Ipsen Ltd, UK) was dissolved in 7.5 cc of normal saline to prepare a solution, 0.1 cc of which contains 6 IU of BT-A. Then, 0.10.2 ml of diluted BT-A was injected intradermally around the lesions using an insulin syringe with a 30-gauge needle. A second BT-A injection session was carried out 34 weeks later for four partially responsive patients. Results: Thirteen patients showed significant flattening of the lesions after the first session. The remaining partially responsive four patients showed considerable flattening after the second boosting session, performed 34 weeks later. The side effects were temporary and minimal. The duration of effect for the BT-A injection was 57 months. Conclusion: Intradermal BT-A injection can be considered as a relatively safe and cost-effective treatment for multiple eccrine hydrocystomas. © 2010 Informa UK Ltd. Source

Saharkhiz N.,Shahid Beheshti University of Medical Sciences | Nikbakht R.,Jondishapour University of Medical science | Salehpour S.,Shahid Beheshti University of Medical Sciences
International Journal of Fertility and Sterility | Year: 2014

Background: Embryo transfer (ET) is one of the most important steps in assisted reproductive technology (ART) cycles and affected by many factors namely the depth of embryo deposition in uterus. In this study, the outcomes of intracytoplasmic sperm injection (ICSI) cycles after blind embryo transfer and embryo transfer based on previously measured uterine length using vaginal ultrasound were compared.Materials and Methods: This prospective randomised clinical trial included one hundred and forty non-donor fresh embryo transfers during January 2010 to June 2011. In group I, ET was performed using conventional (blind) method at 5-6cm from the external os, and in group II, ET was done at a depth of 1-1.5 cm from the uterine fundus based on previously measured uterine length using vaginal sonography. Appropriate statistical analysis was performed using Student’s t test and Chi-square or Fisher’s exact test. The software that we used was PASW statistics version 18. A p value <0.05 was considered statistically significant.Results: Chemical pregnancy rate was 28.7% in group I and 42.1% in group II, while the difference was not statistically significant (p=0.105). Clinical pregnancy, ongoing pregnancy and implantation rates for group I were 21.2%, 17.7%, and 12.8%, while for group II were 33.9%, 33.9%, and 22.1, respectively. In group I and group II, abortion rates were 34.7% and 0%, respectively, indicating a statistically significant difference (p<0.005). No ectopic pregnancy occurred in two groups.Conclusion: The use of uterine length measurement during treatment cycle in order to place embryos at depth of 1-1.5cm from fundus significantly increases clinical and ongoing pregnancy and implantation rates, while leads to a decrease in abortion rate (Registration Number: IRCT2014032512494N1). © 2014 Royan Institute (ACECR). All rights reserved. Source

Shahkarami S.,Jondishapour University of Medical science | Galehdari H.,Shahid Chamran University | Ahmadzadeh A.,Jondishapour University of Medical science | Babaahmadi M.,Jondishapour University of Medical science | Pedram M.,Jondishapour University of Medical science
Nefrologia | Year: 2013

Objective: Nephropatic Cystinosis (NC) is a rare metabolic disorder due to mutation in the CTNS gene in which more than 90 different mutations have already been reported so far. This study was performed to investigate mutations of the CTNS gene and its promoter in a number of Iranian patients with NC. Methods: Polymerase chain reaction and direct sequencing were performed for molecular characterization of the CTNS gene in 25 patients from 24 unrelated Iranian families with NC. Results: None of the patients showed the 57kb deletion in heterozygous or homozygous manner. One was homozygous for a novel mutation, which was termed as "c.153-155insCT", while one of the cases was homozygous and another was compound heterozygous for the second novel mutation c.923G>A. Moreover three known mutations c.18-21delGACT, c.1017G>A, and c.681G>A in 11 of the patients were detected. No apparent mutation was observed in the rest of patients (44%, n=11). Conclusion: The present data exhibit a fundament for molecular carrier detection and prenatal diagnosis of a relatively large percentage of Iranian patients suffering from NC, at least in the Southwestern Iran, where Arab ethnicity is one of the common ethnicities of the region. © 2013 Revista Nefrología. órgano Oficial de la Sociedad Española de Nefrología. Source

Bahmani M.,Lorestan University of Medical Sciences | Rafieian-Kopaei M.,Shahrekord University of Medical Sciences | Karamati S.A.,Shahid Beheshti University of Medical Sciences | Bahmani F.,Ilam University | And 3 more authors.
Asian Pacific Journal of Tropical Disease | Year: 2014

Objective: To identify antiparasitic medicinal plants used by people in southern regions of Ilam province in Iran. Methods: This study was carried out using questionnaire and interview method between February 2012 and April 2013 and also by means of public resources. Along with distributing questionnaires herbarium specimens of each plant were collected and then their genus and species were determined in the Natural Resources Research Center of Ilam province. Results: A total of 19 medicinal plants used as antiparasitic plants belonged to 14 families were identified in southern regions of Ilam province. Majority of antiparasite herbs were related to Compositeae (11%), Rosaceae (11%), Solanaceae (11%), Liliaceae (11%), and Asteraceae (11%) families. Aerial parts with 28% were the most plant organs used for the treatment of parasitic diseases. Results of this study showed that infusion with 83% is the most popular form of herbal medications in southern regions of Ilam province. Conclusions: The report of medicinal plants belonged to northern regions of this province may provide necessary condition for researchers to identify effective substances and to study the clinical effects claimed for these plants and their effective substances on different parasitic diseases while traditional effects of these plants are documented. © 2014 Asian Pacific Tropical Medicine Press. Source

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