Joint Research Laboratory

Darmstadt, Germany

Joint Research Laboratory

Darmstadt, Germany
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Yamamoto N.,Joint Research Laboratory | Matsuyama M.,Aichi University | Sato Y.,Nagoya University | Yan K.,Kyorin University | Yaoita E.,Niigata University
American Journal of Physiology - Renal Physiology | Year: 2011

Uptake of Pi at the cellular membrane is essential for the maintenance of cell viability. However, phosphate overload is also stressful for cells and can result in cellular damage. In the present study, we investigated the effects of the transgenic overexpression of type III Pi transporter Pit-1 to explore the role of extracellular Pi in glomerular sclerosis during chronic renal disease. Pit-1 transgenic (TG) rats showed progressive proteinuria associated with hypoalbuminemia and dyslipidemia. Ultrastructural analysis of TG rat kidney by transmission electron microscopy showed a diffuse effacement of the foot processes of podocytes and a thickening of the glomerular basement membrane, which were progressively exhibited since 8 wk after birth. TG rats died at 32 wk of age due to cachexia. At this time, more thickening of the glomerular basement membrane and segmental sclerosis were observed in glom-eruli of the TG rats. Immunohistochemical examination using anti-connexin 43 and anti-desmin antibodies suggested the progressive injury of podocytes in TG rats. TG rats showed higher Pi uptake in podocytes than wild-type rats, especially under low Pi concentration. When 8-wk-old wild-type and TG rats were fed a 0.6% normal phosphate (NP) or 1.2% phosphate (HP) diet for 12 wk, HP diet-treated TG rats showed more progressive proteinuria and higher serum creatinine levels than NP diet-treated TG rats. In conclusion, our findings suggest that overexpression of Pit-1 in rats induces phosphate-dependent podocyte injury and damage to the glomerular barrier, which result in the progression of glomerular sclerosis in the kidney.© 2011 by the American Physiological Society.© 2011 by the American Physiological Society.


Ellrich J.,Karlsruhe Institute of Technology | Ellrich J.,Joint Research Laboratory | Brand R.A.,Karlsruhe Institute of Technology | Brand R.A.,Joint Research Laboratory | And 2 more authors.
Physica Status Solidi (B) Basic Research | Year: 2010

Interfacial aspects play an important role in the magnetic and structural properties of magnetic thin film systems such as giant or tunnel magneto-resistance devices or storage media applications. However the role of the interaction of atoms in interfaces or close to interfaces is difficult to access experimentally, as the magnetism has to be probed on an atomic level. Not many methods with a suitable resolution in time, space and selectivity are available for such systems. One among them is depth selective Mössbauer spectroscopy which is ideally suited for such investigations due its sensitivity and depth resolution. In addition, the method is isotope selective allowing probing of defined regions. Systems with perpendicular anisotropy such as FePt or CoPt are thought to play a key role in the future of high density storage media applications, although the magnetic interaction of adjacent Fe and Pt atoms is not entirely understood. In this study, the magnetic properties of a single Fe-Pt interface evaluated with atomic resolution as a function of temperature. It is possible to determine the temperature behaviour as well as the ground state properties as a function of distance to the interfacewith a resolution of onemonolayer (ML). © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Ellrich J.,Karlsruhe Institute of Technology | Ellrich J.,Joint Research Laboratory | Kruk R.,Karlsruhe Institute of Technology | Brand R.A.,Karlsruhe Institute of Technology | And 5 more authors.
Hyperfine Interactions | Year: 2012

The purpose of this communication is to show that arrays of FePt with perpendicular anisotropy can be studied using energy-selective conversion electron Mössbauer spectroscopy. Magnetic nanostructures have been in the focus of technology and science for many years. One of the economically and comparably scientifically most demanding application of these structures is in storage devices such as hard-disks and MRAMs. The FePt nanodisks presented here show a combination of material and magnetic properties which enable the fabrication of highly ordered nanostructures. © 2012 Springer Science+Business Media B.V.


Whittle J.D.,University of South Australia | Short R.D.,University of South Australia | Steele D.A.,University of South Australia | Bradley J.W.,University of Liverpool | And 12 more authors.
Plasma Processes and Polymers | Year: 2013

This multi-centre investigation explores the variability that results from using the power/flow rate ratio (W/F) to describe plasma treatment and plasma polymerization processes. Results from fourteen reactors of different design and spread across ten laboratories, showed that the chemistry of the treated and deposited polymer/plasma polymer films is highly variable between reactor systems, and that there was no clear pattern linking these variations to other properties of the reactor systems (e.g. pressure, volume, electrode configuration). Although W/FM provides a useful rule-of-thumb for process optimization within a single system, it does not provide sufficient information to enable the same plasma polymer to be produced on a different system. The variability of plasma treatments and processes in laboratory plasma systems is explored through a round-robin study. Substantial differences are observed between reactor systems, both in the degree of plasma treatment, and the functional group retention and deposition rate of plasma polymerized acrylic acid. The results illustrate the importance of characterizing and understanding the effect of plasma properties directly. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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