Johnson and Johnson Pharmaceutical Development

Beerse, Belgium

Johnson and Johnson Pharmaceutical Development

Beerse, Belgium
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Lemaire S.,Johnson and Johnson Pharmaceutical Development | Houpis I.,Johnson and Johnson Pharmaceutical Development | Wechselberger R.,Johnson and Johnson Pharmaceutical Development | Langens J.,Johnson and Johnson Pharmaceutical Development | And 12 more authors.
Journal of Organic Chemistry | Year: 2011

Diastereoselective hydrogenation of 2′-deoxy-2′-exo- methyleneuridine was carried out under homogeneous conditions using a low loading of a chiral Rh catalyst. This, coupled with improvements in the synthesis of the substrate, allowed the smooth pilot plant preparation of the title compound on >10 kg scale. © 2010 American Chemical Society.


PubMed | Johnson and Johnson Pharmaceutical Development
Type: Journal Article | Journal: The Journal of organic chemistry | Year: 2011

Diastereoselective hydrogenation of 2-deoxy-2-exo-methyleneuridine was carried out under homogeneous conditions using a low loading of a chiral Rh catalyst. This, coupled with improvements in the synthesis of the substrate, allowed the smooth pilot plant preparation of the title compound on >10 kg scale.

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