Entity

Time filter

Source Type


Lemaire S.,Johnson and Johnson Pharmaceutical Development | Houpis I.,Johnson and Johnson Pharmaceutical Development | Wechselberger R.,Johnson and Johnson Pharmaceutical Development | Langens J.,Johnson and Johnson Pharmaceutical Development | And 12 more authors.
Journal of Organic Chemistry | Year: 2011

Diastereoselective hydrogenation of 2′-deoxy-2′-exo- methyleneuridine was carried out under homogeneous conditions using a low loading of a chiral Rh catalyst. This, coupled with improvements in the synthesis of the substrate, allowed the smooth pilot plant preparation of the title compound on >10 kg scale. © 2010 American Chemical Society. Source

Discover hidden collaborations