Johnson and Johnson Pvt Ltd
Johnson and Johnson Pvt Ltd
Dureja G.P.,Delhi Pain Management Center |
Iyer R.N.,Raja Rajeswari Medical College and Hospital |
Das G.,Daradia Pain Clinic |
Ahdal J.,Johnson and Johnson Pvt Ltd |
Narang P.,Johnson and Johnson Pvt Ltd
Journal of Pain Research | Year: 2017
Despite enormous progress in the field of pain management over the recent years, pain continues to be a highly prevalent medical condition worldwide. In the developing countries, pain is often an undertreated and neglected aspect of treatment. Awareness issues and several misconceptions associated with the use of analgesics, fear of adverse events – particularly with opioids and surgical methods of analgesia – are major factors contributing to suboptimal treatment of pain. Untreated pain, as a consequence, is associated with disability, loss of income, unemployment and considerable mortality; besides contributing majorly to the economic burden on the society and the health care system in general. Available guidelines suggest that a strategic treatment approach may be helpful for physicians in managing pain in real-world settings. The aim of this manuscript is to propose treatment recommendations for the management of different types of pain, based on the available evidence. Evidence search was performed by using MEDLINE (by PubMed) and Cochrane databases. The types of articles included in this review were based on randomized control studies, case–control or cohort studies, prospective and retrospective studies, systematic reviews, meta-analyses, clinical practice guidelines and evidence-based consensus recommendations. Articles were reviewed by a multidisciplinary expert panel and recommendations were developed. A stepwise treatment algorithm-based approach based on a careful diagnosis and evaluation of the underlying disease, associated comorbidities and type/duration of pain is proposed to assist general practitioners, physicians and pain specialists in clinical decision making. © 2017 Dureja et al.
Kurmi M.,National Institute of Pharmaceutical Education and Research |
Patel N.,National Institute of Pharmaceutical Education and Research |
Jhajra S.,Johnson and Johnson Pvt. Ltd. |
Bharatam P.V.,National Institute of Pharmaceutical Education and Research |
Singh S.,National Institute of Pharmaceutical Education and Research
Journal of Pharmaceutical and Biomedical Analysis | Year: 2017
Mass spectrometry tools (HRMS/LC-HRMS, MSn, and/or on-line H/D exchange) were employed to establish mass fragmentation pattern of torasemide and to characterize its degradation products. During collision-induced dissociation, multiple rearrangement processes and unusual losses of sulfur (S), sulfanyl (HS[rad]), sulfur dioxide (SO2), sulphinic acid radical (HSO2[rad]), sulfur monoxide (SO), carbon monoxide (CO), formyl radical (CHO[rad]) and C5H3NOS were observed. The same were successfully explained by study of energy profiles, established by application of density functional theory (DFT). © 2017 Elsevier B.V.