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Galzote C.,Johnson and Johnson China Ltd. | Estanislao R.,Johnson and Johnson Philippines Inc. | Suero M.O.,Johnson and Johnson Philippines Inc. | Khaiat A.,Johnson and Johnson Asia Pacific | And 3 more authors.
Skin Research and Technology | Year: 2014

Background/purpose: This multicenter study assessed the impact of two types of extreme seasons (i.e. summer and winter) on the facial skin of female subjects living in different regions of Asia. Methods: Facial skin of female subjects of various Asian ethnicities was characterized during summer and winter using dermatological assessments of the cheek and instrumental evaluations of the forehead and cheek. Approximately, 100 female subjects each from five cities in Asia (Harbin and Shanghai in China; New Delhi, India; Seoul, South Korea; and Sendai, Japan) ranging in age from 14 to 75 years were included in this study. Results: Dermatologist assessments revealed a general decrease in severity of roughness, wrinkles, pigmentation, and lentigines during winter compared with summer. Instrumental assessments revealed significant differences in various parameters in winter vs. summer such as reductions in melanin index and skin surface hydration, and increases in transepidermal water loss, skin pH, redness, and sebum production. Conclusion: Facial skin in female subjects living in different Asian cities exhibited a wide range of changes and worsening of various biophysical parameters in response to the low temperature and humidity during the winter season as compared with summer. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Galzote C.,Johnson and Johnson China Ltd. | Estanislao R.,Johnson and Johnson Philippines Inc. | Suero M.O.,Johnson and Johnson Philippines Inc. | Khaiat A.,Johnson and Johnson Asia Pacific | And 3 more authors.
Skin Research and Technology | Year: 2013

Background/purpose: We aimed to evaluate the impact of age and skincare habits on facial skin of different Asian ethnicities by comparing skin properties and skincare habits among various Asian populations of varying age groups. Methods: We evaluated approximately 100 female subjects each from a total of eight Asian cities in China, India, South Korea, Japan, and the Philippines grouped according to age ranging from 14 to 75 years during a summer season. Facial skin was characterized using dermatological examinations of the cheek and instrumental evaluations of the forehead and cheek. Information regarding personal skincare habits was collected using a questionnaire. Results: In 834 female subjects, characteristics related to skin surface moisture, elasticity, and sebum level decreased with age. Differences in skincare habits corresponded with variations in skin parameters. Subjects with the least severe photodamage reported a generally early onset of their skincare habits. Conclusion: These results demonstrate common trends as well as inherent differences in skin characteristics among Asian populations, reflecting the impact of age and the diversity of skincare habits of Asian women. These results may be beneficial when developing new skincare products that are well suited to these Asian populations. © 2013 John Wiley & Sons A/S.

Wu V.,PPD Pharmaceutical Development Beijing Co. | Bao W.-J.,SAS Institute | Wang J.,Johnson and Johnson China Ltd. | Peng R.-L.,Improve-in | And 2 more authors.
Yaoxue Xuebao | Year: 2015

CDISC standard has become a set of global data standards that can be used in clinical study, covering the full life cycle of clinical researches. After nearly 20 years of development and continuous version upgrades, CDISC standard can improve the quality and efficiency of clinical research and drug review, and to facilitate all stakeholders involved in researches to exchange the study data and communicate the outcomes. CDISC standard has been or is to be adopted as standard format in data submission by multiple regulatory authorities, and more widely implemented by the global pharmaceutical community. CDISC standard is gradually adopted in China. The feasibility and roadmap of CDISC standard as the Chinese data submission format requirements are undergoing exploration and piloting further.

Ying S.,Fudan University | Zeng D.-N.,Fudan University | Chi L.,Fudan University | Tan Y.,Johnson and Johnson China Ltd. | And 8 more authors.
PLoS ONE | Year: 2015

Differences in the bacterial community structure associated with 7 skin sites in 71 healthy people over five days showed significant correlations with age, gender, physical skin parameters, and whether participants lived in urban or rural locations in the same city. While body site explained the majority of the variance in bacterial community structure, the composition of the skin-associated bacterial communities were predominantly influenced by whether the participants were living in an urban or rural environment, with a significantly greater relative abundance of Trabulsiella in urban populations. Adults maintained greater overall microbial diversity than adolescents or the elderly, while the intragroup variation among the elderly and rural populations was significantly greater. Skin-associated bacterial community structure and composition could predict whether a sample came from an urban or a rural resident ∼5x greater than random. © 2015 Ying et al. This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

Liu T.,Johnson and Johnson China Ltd. | Pan Y.,Johnson and Johnson China Ltd. | Lai R.,Johnson and Johnson China Ltd.
Natural Product Communications | Year: 2014

Cell division protein, FtsZ, has been identified as a new potential antimicrobial target against multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA). By using computer-aided simulation, the phenolic compounds magnolol and honokiol from Magnolia officinalis were shown to have high anchor energies to FtsZ of S.aureus. The calculated binding energies of magnolol and honokiol for this FtsZ (PDB Code: 4DXD) were established to be -7.6 kcal/mol and -8.2 kcal/mol, respectively. Both of them showed polymerization inhibition efficacy for this FtsZ at 100 ppm, which confirmed the simulation results. Their antibacterial activity against S. aureus including multidrug-resistant (MDR) and methicillin-resistant S.aureus (MRSA) with minimum inhibitory concentration (MIC) values in the range of 8-16 ppm. These findings support the use of computer-aided simulation to screen natural compounds for this cell division protein, FtsZ, and this method can be a quick and promising approach for the development of antimicrobial agents against multi-drug resistant S. aureus. © 2014, Natural Product Incorporation. All rights reserved.

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