ALZA Johnson and Johnson

United States

ALZA Johnson and Johnson

United States
SEARCH FILTERS
Time filter
Source Type

Dai W.-G.,Johnson and Johnson Pharmaceutical Research and Development | Dong L.C.,ALZA Johnson and Johnson | Li S.,ADDS Pharmaceuticals LLC | Pollock-Dove C.,ADDS Pharmaceuticals LLC | Deng Z.,Pacific Biosciences
Drug Delivery Technology | Year: 2010

In this study, we reported a significantly reduced drug-apparent solubility during a micronization process. A poorly water-soluble compound was micronized by jet-milling and mortar/pestle-milling. Both milling processes reduced the particle size to approximately 5 micrometers. However, mortar/pestle-milling significantly reduced the compound's apparent solubility (p < 0.01) and thermodynamic solubility (p < 0.02) in simulated gastric fluid (SGF) (pH 1.2), whereas jet-milling did not alter compound solubility. Despite solubility differences, the jet-milled and mortar/pestle-milled samples did not show major differences by Differential Scanning Calorimetry (DSC) and X-ray Diffraction (XRD) analyses. The results in this study have clearly demonstrated the significant influences of different milling processes on compound solubility.

Loading ALZA Johnson and Johnson collaborators
Loading ALZA Johnson and Johnson collaborators