Joben Bio medical Company

Pingtung, Taiwan

Joben Bio medical Company

Pingtung, Taiwan

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Liang M.-T.,I - Shou University | Liang R.-C.,I - Shou University | Huang L.-R.,I - Shou University | Liang K.-Y.,Jope Technology Service Company | And 2 more authors.
Journal of the Taiwan Institute of Chemical Engineers | Year: 2014

This study employs the SFE (supercritical fluid extraction) to extract the triterpenoids from the fruiting bodies of Antrodia cinnamomea ( Syn. Antrodia camphorata and Taiwanofugus camphorata) cultivated in Petri-dish, followed by applying SF-SMB (supercritical fluid-simulated moving bed) to remove impurities from the crude extract of SFE to enrich the triterpenoids. Ethanol is used as cosolvent for the SFE extraction and SMB separation. A three-section SMB with open-loop design is employed and silica gel and C18 adsorbent are used as adsorbent. Four SMB experiments were designed and conducted to study the feasibility in removing impurities from the crude extract. When silica gel is used, two experiments of SF-SMB were conducted. The first SF-SMB experiment is conducted at constant concentration of ethanol and called as iso-SF-SMB, and the second experiment is designed to create gradient of elution power along the columns of the SMB unit and named as grad-SF-SMB. If RP-18 is used, iso-SF-SMB and classical SMB with liquid as desorbent are testified. The results show that grad-SF-SMB with silica gel has the highest effectiveness on removing the impurities and iso-SF-SMB with silica gel can also be applied to remove the impurities. The iso-SF-SMB with RP-18 can also be used for removing impurities with little loss of the triterpenoids, but classical SMB with RP-18 is not suitable for removing impurities from the crude extract. This study demonstrates that grad-SF-SMB could be a useful technology for developing botanical drugs and provides greener alternative for industries. This study also found that the operation of iso-SF-SMB and grad-SF-SMB can only qualitatively predictable by the triangle theory, and the removing of impurities can mainly achieved by serial trials. © 2013 Taiwan Institute of Chemical Engineers.


Tseng H.-C.,Joben Bio medical Co | Tseng H.-C.,National Pingtung University of Science and Technology | Wu W.-T.,National Pingtung University of Science and Technology | Huang H.-S.,Joben Bio medical Co | Wu M.-C.,National Pingtung University of Science and Technology
International Journal of Food Sciences and Nutrition | Year: 2014

The antimicrobial activities of longan (Dimocarpus longan Lour. Fen ke) seed extracts were investigated using a disc diffusion method and also determining the minimal inhibitory concentration. The DL-P01-SI01 fraction showed that the strongest activity against Staphylococcus aureus and methicillin-resistant S. aureus at MIC 64 μg/mL, which was found to be due to the phenolic compounds. The HPLC analysis showed that the major phenolic compounds are gallic acid, corilagin, ethyl gallate and ellagic acid. © 2014 Informa UK Ltd. All rights reserved.


Trademark
Joben Bio Medical Co. and Joray Bio Medical CO. | Date: 2011-03-08

Medical and surgical dressings; Wound dressings; Medical and surgical plasters; Medical plasters; Anti-inflammatories; Anti-inflammatory sprays; Pharmaceutical preparations for skin care.


Patent
Joben Bio Medical Co. | Date: 2015-10-28

The present invention provides a composition comprising extract of adlay bran, wherein the adlay bran extract comprises C1 to C7 alcohol extract of adlay bran (A) and carbon dioxide supercritical fluid extract of adlay bran (B). Preferably, the extract of adlay bran has effects in treating a skin and/or subcutaneous tissue disease and in lowering interleukin (IL)-1, interleukin-1, interleukin-6, tumor necrosis factor (TNF)-, interleukin-8, prostaglandin-2 (PGE2) and/or C-Reactive Protein (CRP).


Patent
Joben Bio Medical Co. | Date: 2015-08-05

The present invention provides use of alcohol extract of longan seeds for manufacturing a drug for treating kidney tissue dysfunction. Preferably, an ethyl acetate sub-fraction of the alcohol extract of longan seeds has a better effect in treating kidney tissue dysfunction.


Patent
Joben Bio Medical Co. | Date: 2014-11-12

The present invention provides a composition comprising extract of adlay bran, wherein the adlay bran extract comprises C1 to C7 alcohol extract of adlay bran (A) and carbon dioxide supercritical fluid extract of adlay bran (B). Preferably, the extract of adlay bran has effects in treating a skin and/or subcutaneous tissue disease and in lowering interleukin (IL)-1, interleukin-1, interleukin-6, tumor necrosis factor (TNF)-, interleukin-8, prostaglandin-2 (PGE2) and/or C-Reactive Protein (CRP).


Jbm

Trademark
Joben Bio Medical Co. | Date: 2014-03-28

Dietary and nutritional supplements; Fungal extracts sold as a component ingredient of nutritional supplements and vitamins; Health food supplements; Nutraceuticals for use as a dietary supplement; Nutritional food additives for medical purposes in the nature of natural food extracts derived from Antrodia camphorate; Nutritional supplements; Pharmaceutical preparations for the prevention and treatment of disorders of the nervous system, the immune system, the cardio-vascular system, the metabolic system, the respiratory system, the musculo-skeletal system, the genitourinary system; Pharmaceutical preparations for the treatment of inflammatory disorders; Pharmaceutical preparations for use in dermatology, oncology, hematology and in tissue and organ transplantation, in ophthalmology and for gastroenterological disorders; Powdered nutritional supplement concentrate; Prescription and non-prescription medicines, namely, pills, tablets, capsules, caplets, liquid drops, sachets and pharmaceutical preparations for the treatment of cardiovascular disorders; Therapeutic pharmaceutical for the treatment of hepatoprotective, cholesterol-lowering, promoting blood circulation and boosting metabolism, regulation in blood pressure, regulation in blood lipids, regulation in blood sugar, immunomodulatory, promoting immune system, regulation of allergy.


Patent
Joben Bio Medical Co. | Date: 2013-03-15

The present invention provides a composition comprising extract of adlay bran, wherein the adlay bran extract comprises C1 to C7 alcohol extract of adlay bran (A) and carbon dioxide supercritical fluid extract of adlay bran (B). Preferably, the extract of adlay bran has effects in treating a skin and/or subcutaneous tissue disease and in lowering interleukin (IL)-1, interleukin-1, interleukin-6, tumor necrosis factor (TNF)-, interleukin-8, prostaglandin-2 (PGE2) and/or C-Reactive Protein (CRP).


Patent
Joben Bio Medical Co. | Date: 2015-02-03

The present invention provides a composition comprising extract of adlay bran, wherein the adlay bran extract comprises C1 to C7 alcohol extract of adlay bran (A) and carbon dioxide supercritical fluid extract of adlay bran (B). Preferably, the extract of adlay bran has effects in treating a skin and/or subcutaneous tissue disease and in lowering interleukin (IL)-1, interleukin-1, interleukin-6, tumor necrosis factor (TNF)-, interleukin-8, prostaglandin-2 (PGE2) and/or C-Reactive Protein (CRP).


Patent
Joben Bio Medical Co. | Date: 2013-03-18

The present invention provides use of alcohol extract of longan seeds for manufacturing a drug for treating kidney tissue dysfunction. Preferably, an ethyl acetate sub-fraction of the alcohol extract of longan seeds has a better effect in treating kidney tissue dysfunction.

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