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Gomes M.B.,State University of Rio de Janeiro | Negrato C.A.,Baurus Diabetics Association | Calliari L.E.P.,Pediatric Endocrine Unit | Cobas R.,State University of Rio de Janeiro | And 43 more authors.
Diabetes Research and Clinical Practice

Aims: Determine the relationship between age at menarche, glycemic control and cardiovascular risk factors in patients with type 1 diabetes living in urban areas. Methods: This was a multicenter cross-sectional study conducted in 20 cities in four Brazilian geographic regions. Data were obtained from 1527 female patients, 59.3% Caucasians, aged 25.1. ±. 10.6 years. Diabetes duration was 11.4. ±. 8.1 years. Age at menarche was stratified in four groups: 8-11 (group 1, early menarche), 12 (group 2), 13 (group 3) and 14-18 years (group 4, late menarche). Results: The mean age at menarche was 12.7. ±. 1.7 years without difference among geographical regions, economic status, level of care and ethnicity. BMI had an inverse correlation with age at menarche (r = -0.14, p<. 0.001). No significant difference was observed among the four groups for blood pressure, lipid profile and diabetes-related chronic complications. Logistic regression analysis showed that early age at menarche, 8-11 years (odds ratio (ORs) 1.77 [1.30-2.41], p<. 0.001) and duration of diabetes [ORs 1.01 (1.00-1.03), p = 0.02], were related to greater risk of patients' overweight or obesity; adherence to diet [ORs 0.78 (0.60-0.93), p = 0.01], physical activity [ORs 0.75 (0.94-0.94), p = 0.01], and lower insulin dose (U/kg) [ORs 0.54 (0.59-0.90), p = 0.001] were related to lower risk for overweight or obesity. Conclusions: Early menarche occurred in 23.4% of women with type 1 diabetes living in Brazilian urban areas and was strongly associated with overweight/obesity in pubertal/adult life. Further studies are warranted to establish the relationship between early menarche, glycemic control and cardiovascular risk factors. © 2014 Elsevier Ireland Ltd. Source

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