Shah D.,Thomas Jefferson University |
Mahajan N.,Panjab University |
Sah S.,JNMC |
Nath S.K.,Oklahoma Medical Research Foundation |
Paudyal B.,Thomas Jefferson University
Journal of Biomedical Science | Year: 2014
Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease whose etiology remains largely unknown. The uncontrolled oxidative stress in SLE contributes to functional oxidative modifications of cellular protein, lipid and DNA and consequences of oxidative modification play a crucial role in immunomodulation and trigger autoimmunity. Measurements of oxidative modified protein, lipid and DNA in biological samples from SLE patients may assist in the elucidation of the pathophysiological mechanisms of the oxidative stress-related damage, the prediction of disease prognosis and the selection of adequate treatment in the early stage of disease. Application of these biomarkers in disease may indicate the early effectiveness of the therapy. This review is intended to provide an overview of various reactive oxygen species (ROS) formed during the state of disease and their biomarkers linking with disease. The first part of the review presents biochemistry and pathophysiology of ROS and antioxidant system in disease. The second part of the review discusses the recent development of oxidative stress biomarkers that relates pathogenesis in SLE patients and animal model. Finally, this review also describes the reported clinical trials of antioxidant in the disease that have evaluated the efficacy of antioxidant in the management of disease with ongoing conventional therapy. © 2014 Shah et al.; licensee BioMed Central Ltd.
Taksande A.,JNMC |
Shiraz E Medical Journal | Year: 2013
Background: Dengue Fever (DF) is an emergent disease in India. It is endemic in some parts of country and contributes annual outbreaks of dengue. Aims: To study the knowledge regarding dengue and the preventive measures practiced by the rural population attending a hospital. Setting: The Jawaharlal Nehru Medical College, Sawangi Meghe, Wardha is the rural medical college located in Maharashtra. Study Design: The study design was a descriptive cross-sectional study concerning Knowledge, Attitudes, and Practices of DF prevention among the people in Rural Hospital of Central India. Study population: The population in this study was residents of Wardha Districts, Maharashtra State, India, who were living there for at least one year. A 410 adults (aged 18 years and above) were interviewed using a pre-tested questionnaire regarding their knowledge, attitude and practices about DF. Results: 43.91 % respondents belonged to the age group of 30 - 44 years, 84.15 % respondents were married and 31.21 % respondents were high school certificate (31.21 %). 76.58 % respondent knew that the vector for dengue is a mosquito. Whereas 47.8 % respondents knew that human to human spread occurs in dengue and mainly transmitted by mosquito bites. Around 60.48 % of them were aware of fever as the presenting symptom. With regards to the knowledge of the preventive measures, respondents were generally aware of mosquito coils/liquid (57.08 %) and spraying (35.12 %). 74.14 % respondents knew about breeding places of mosquitoes. 94.64 % respondents strongly agreed and agreed that dengue is a serious illness. Only 17.06 % respondents strongly agreed and agreed that they are at risk of getting dengue whereas 62.92 % was not sure about the risk. Common preventive practices that were prevalent in the respondents were use of mosquito coils/liquid (45.12 %); cleaning the house (28.30 %) and mosquito spray (23.42 %). Important sources of information about DF were from television (59.75 %) followed by Friends/relatives (47.80 %). Conclusion: The DF remains a public health problem in this area and the people need more understanding of the disease. Our findings highlight the need for further information, education and communication programs. Preventive strategies are the only means of controlling the DF. © 2012, Shiraz E Medical Journal, Shiraz, Iran. All rights reserved.
Bhute A.A.,JNMC |
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2016
Vulvovaginal Candidiasis (VVC) Vulvovaginal candidiasis (VVC) is a Reproductive tract infection affecting millions of women worldwide. In developing countries, the prevalence of this infection has increased in recent years. To study the pharmacoepidemological perspective of Vaginal candidiaisis, it was compared to the other abnormal vaginal discharge diseases. 221 Vaginal candidiasis patients were studied out of 350 abnormal vaginal discharge patients. Itching was the most presenting symptom, while incidence was high in 21-35 age group. The majority of the patients belonged to low socioeconomic strata. Vaginal Candidiasis was predominantly seen more in patients with pregnancy. Fluconazole 150 mg once was the main treatment given while in topical Clotrimazole and Miconazole vaginal pesseries were used which relieved the symptoms. Multivitamin tablets (19%) and Ranitidine (6.87%) were prescribed for symptomatic relief.
Naaz S.,Jamia Hamdard University |
Journal of Clinical and Diagnostic Research | Year: 2014
Dexmedetomidine is an alpha 2 adrenergic receptor agonist, even ten times more selective than clonidine. It is a very versatile drug in anaesthesia practice, finding place in increasing number of clinical scenarios and is no more limited to intensive care unit (ICU) sedation. It is analgesic, has anaesthetic sparing effect, sympatholytic property, useful in other procedural sedation and also has cardiovascular stabilizing property. It reduces delirium and preserves respiratory function which adds benefits to its uses. The aim of this review is to make awareness of its role in present anaesthesia and discuss its limitations at the same time. © 2014, Journal of Clinical and Diagnostic Research. All Rights Reserved.
Ahmad I.,JNMC |
Indian Journal of Otolaryngology and Head and Neck Surgery | Year: 2013
Ameloblastoma or adamantinoma is a benign odontogenic tumour arising in facial bones mostly in mandible. There are different modalities of treatment for ameloblastoma viz. chemotherapy, radiation therapy, curettage and liquid nitrogen but surgical resection or enucleation remains the most definitive treatment for this condition. After surgical excision mandibular defect can be reconstructed by non vascularised bone graft or free tissue transfer. we are presenting a detailed study of 50 patients in which mandible was reconstructed with non vascularised split rib graft after surgical resection of ameloblastoma. This is easy, less time consuming and requires no expertise with excellent results. © 2012 Association of Otolaryngologists of India.