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Hisalkar P.J.,JMFs ACPM Medical College and Hospital | Patne A.,JMFs ACPM Medical College and Hospital | Shinde R.,JMFs ACPM Medical College and Hospital | Karnik A.,JMFs ACPM Medical College and Hospital | Mumbre S.,NDMVP Medical College and Hospital
Biomedicine | Year: 2010

Background: Behcet's disease is a chronic, recurrent, multi-systemic inflammatory disorder of unknown aetiology, characterised by the triad of oral ulcers, gential ulcers and ocular lesions. It has shown that many antioxidants decrease in BD.The Purpose of this study was aimed to assess whether the increased oxidative stress in affected tissues was reflected by serum lipid peroxidation and to check for alterations in serum levels of extracellular antioxidants and antioxidant enzyme activities in patients with Behcet's disease (BD). Method: Prospective measurement of biochemical analysis were studied using appropriate methods. Results: It was observed that serum lipid peroxide (MDA) was significantly increased and decrease in the levels of antioxidants like superoxide dismutase, glutathione peroxidase, zinc, ascorbic acid, albumin, uric acid, total bilirubin were observed in BD patients as compared to normals. Conclusion: The present study clearly indicates an increased oxidative stress, evidenced by raised serum lipid peroxide levels and decreased antioxidants evidenced by reduced superoxide dismutase and glutathione peroxidise activity may cause membrane damage due to disturbed state of pro- and antioxidant activity. In the light of these data, it is necessary to consider the possibility of development of atherosclerosis while evaluating BD cases. It can be considered that elevated lipid peroxide level is a predisposing factor in BD and impaired antioxidant status may be prevented by antioxidant therapy. Source

Nikumbh D.B.,JMFs ACPM Medical College and Hospital | Suryawanshi K.H.,JMFs ACPM Medical College and Hospital | Dravid N.V.,JMFs ACPM Medical College and Hospital | Patil T.B.,JMFs ACPM Medical College and Hospital | Rokade C.M.,JMFs ACPM Medical College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2013

Malignant Peripheral Nerve Sheath Tumours (MPNST) are rare spindle-cell sarcomas which are derived from the schwann cells or the pleuripotent cells of the neural crest. MPNSTs are usually located in the peripheral nerve trunk roots, extremities and in the head and neck region. These tumours may arise as sporadic variants or in patients with neurofibromatosis1 (NF1). The estimated incidence of MPNSTs in the patients with NF1is 2-5% as compared to a 0.001% incidence in the general population. Herein, we are reporting a case of a giant sporadic (NF1 independent) low grade MPNST of the left thigh in 65 year female patient, which had a good prognosis. Source

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