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Vijayakumar M.,Jkkmunirajah Medical Research Foundation | Balasubramaniam A.,Jkkmunirajah Medical Research Foundation | Manivannan R.,Jkkmunirajah Medical Research Foundation | Kumar N.S.,Jkkmunirajah Medical Research Foundation
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010

To combat oxidative stress due to diabetic, administration of moderate quality of ethanol extracts of the Bauhinia tomentosa (Linn.) flower were suggested. The objective of the present study was to assess the antioxidant efficacy of ethanol extracts of the Bauhinia tomentosa (Linn.) flower. In diabetic rats, oxidative damage was studied by assessing parameters such as thiobarbituric acid reactive substances (TBARS), Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and glutathione-S-transferase (GST) in liver and kidneys, and also serum glutamate oxaloacetate transferase (SGOT), serum glutamate pyruvate transaminase (SGPT), Alkaline phosphatase (ALP), Total Protein in serum/liver/kidneys. The effect of co-administration of ethanol extracts of the Bauhinia tomentosa (Linn.) flower on the above parameters was further investigated. Lipid peroxidation as evidenced by an increment in the values of TBARS, Hydroperoxides and also a distinct diminution of levels of GSH in diabetic rats was found to be near normalcy. Antioxidant enzymes such as SOD, CAT, GPx and GST too showed enhanced activities on co-administration of ethanol extracts of the Bauhinia tomentosa (Linn.) flower. Source

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