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Menezes L.M.,JKK Nataraja Dental College and Hospital
Quintessence international (Berlin, Germany : 1985) | Year: 2012

To compare the long-term clinical outcomes obtained by the combination of platelet-rich plasma (PRP) and a porous hydroxyapatite at the test site with those obtained from the use of a mixture of hydroxyapatite and saline at the control site in the treatment of human intraosseous defects. Sixty healthy, nonsmoking subjects diagnosed with chronic periodontitis were included in this study. Using a split-mouth design, intraosseous defects were surgically treated with a combination of PRP and a porous hydroxyapatite or a mixture of hydroxyapatite and saline. Clinical measurements and radiographic evaluation were performed at baseline and 1 and 4 years postoperatively. When compared with baseline, the 1-year results showed no significant changes. However, the 4-year results indicated that while both treatment modalities resulted in significant changes in all clinical parameters (probing depth, relative attachment level, gingival recession, and intraosseous defect fill; P < .001), the test group exhibited statistically significant changes compared with the control group: probing depth reduction, 5.8 ± 0.49 mm vs 4.0 ± 0.45 mm (P < .0001); clinical attachment gain, 5.4 ± 1.2 mm vs 3.1 ± 1.1 mm (P < .0001); and defect fill, 3.2 ± 0.8 mm vs 2.1 ± 0.6 mm (P < .0001). Treatment with a combination of PRP and hydroxyapatite compared with hydroxyapatite with saline led to a significantly more favorable clinical improvement in intraosseous periodontal defects. Source


Doshi U.H.,JKK Nataraja Dental College and Hospital
Orthodontics : the art and practice of dentofacial enhancement | Year: 2011

In conjunction with the lips, tongue, and oropharynx, the teeth play an important role in the articulation of consonants via airflow obstruction and modification. Therefore, along with these articulators, any orthodontic therapy that changes their position may play a role in speech disorders. This paper examines the relevant studies and discusses the difficulties of scientific investigation in this area. The ability of patients to adapt their speech to compensate for most handicapping occlusion and facial deformities is recognized, but the mechanism for this adaptation remains incompletely understood. The overall conclusion is that while certain malocclusions show a relationship with speech defects, this does not appear to correlate with the severity of the condition. There is no direct cause-and-effect relationship. Similarly, no guarantees of improvement can be given to patients undergoing orthodontic or orthognathic correction of malocclusion. Source


Goyal B.R.,Nirma University | Mehta A.A.,JKK Nataraja Dental College and Hospital
Human and Experimental Toxicology | Year: 2013

Several experimental, pathological, epidemiological, and clinical studies have clearly depicted that diabetes mellitus results in cardiac functional and structural changes. Diabetic cardiomyopathy results in both structural and functional alterations in the myocardium. Several mechanisms have been implicated in the pathophysiology of diabetic cardiomyopathy. Of these, metabolic disturbances, myocardial fibrosis, small vessel disease, and cardiac autonomic neuropathy are the major players in the pathophysiology of diabetic cardiomyopathy. This review is intended to discuss various such pathophysiological mechanisms of diabetic cardiomyopathy. We have also described the systolic and diastolic dysfunctioning and its corelation to structural changes in diabetes. © 2013 The Author(s). Source


Grover V.,JKK Nataraja Dental College and Hospital
Indian journal of dental research : official publication of Indian Society for Dental Research | Year: 2011

Although bone allografts are being widely used in dentistry, many of clinicians appear to be unfamiliar with their preparation and processing as well as their use as safe and effective graft materials. The major concerns associated with these materials are antigenicity and risk of disease transmission from donor to recipient. To minimize this risk, the production of an allograft worthy of distribution and implantation requires strict attention to detail through a comprehensive process. With an increasing clinical requirement for bone grafting procedures, there is a commensurate increase in patients' demands for assurance that bank bone will not be infected with pathogens. To ensure the patients, dental surgeons should be able to cite factual information and recommendations by responsible organizations regarding safety of allografts. Knowledge of human bone allograft procurement, processing, and tracking may allow dentists to better educate patients and address concerns about this valuable treatment option. The purpose of this review is to furnish and update the current knowledge on processing, safety, and efficacy of allograft materials. Source


Bhattacharya S.,JKK Nataraja Dental College and Hospital
Research Journal of Medicinal Plant | Year: 2011

Mutagens are not only involved in genotoxicity and carcinogenesis but also involved in the inception and pathogenesis of several chronic degenerative hseases including hepatic disorders, neurodegenerative hsorders, carhovascular hsorders, habetes, arthritis, chronic inflammation and i n the process of ageing. One of the best ways to minimize the detrimental effects of mutagens is by the use of natural antimutagens. Naturally occurring antimutagenic principles present in plants, human h e t and other sources have protective effects against mutagens. These include flavonoids, phenolics, coumarins, carotenoids, anthraquinones, tannins, saponins and many more Present review attempts to furnish a brief overview on natural products conferring antimutagenicity. © 2011 Academic Journals Inc. Source

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