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Thamotharan G.,Jkk Munirajah Medical Research Foundation | Sekar G.,Jkk Munirajah Medical Research Foundation | Ganesh T.,Jkk Munirajah Medical Research Foundation | Senthil Kumar N.,Jkk Munirajah Medical Research Foundation
Asian Journal of Pharmaceutical and Clinical Research | Year: 2010

Ethnobotanical knowledge of medicinal plants is some of the most prominent sources of new drugs and has shown potential results for the treatment of gastrointestinal disorders. In order to establish the pharmacological basis for the ethno medicinal use of Lantana camara Linn. in gastrointestinal affections, this study examined the effects of methanol extract of leaves (MELC), on aspirin, ethanol and cold restraint stress induced gastric lesions in rats. Study has shown anti-ulcer activity of extract in dose dependent manner. MELC decreases volume of gastric juice, total acidity, free acidity and increases pH significantly (P<0.001) in aspirin induced gastric ulcer. Pre-treatment with the extract (200 and 400 mg/kg) showed ulcer protective effect in aspirin induced (63.31%, 71.02% protection), ethanol induced (85.79%, 93.09% protection) and cold restraint stress induced (46.86%, 63.90% protection) ulcer models. Extract also possess in vivo antioxidant activity as it increases superoxide dismutase, catalase, reduces glutathione in extract treated group. The results indicate anti-ulcer potential of MELC.

Vincent S.,JKK Munirajah Medical Research Foundation | Vijayamirtharaj R.,JKK Munirajah Medical Research Foundation | Wilson P.,JKK Munirajah Medical Research Foundation | Saravanan B.,JKK Munirajah Medical Research Foundation | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

Clerodendrum phlomidis. Belonging to family Verbaneceae is an evergreen parasitic plant grown on different host plant throughout India. Present study is carried out to investigate and prove ethno medicinal value of the plant. C. phlomidis showed antifungal activity against plant and human pathogens but it is more effective in plants. It was tested by poison plate Technique. Authenticated plant leaves were taken for the study includes extraction of aerial part using different solvents and evaluation of anthelmintic activities. Coarse dried aerial parts of the plant were extracted successively by soxhlet using petroleum ether, chloroform, ethyl acetate and methanol as solvents according to their increasing polarity. Dried extracts were tested for anthelmintic activity using Pheretima posthuma as a species of earth worm and compare the paralysis time and death time with standard drug albendazole. Ethyl acetate and methanol extracts shows comparable anthelmintic activity with standard drug albendazole. Methanol and ethyl acetate extracts were tested by different chemical tests. It shows presence of tannins, flavonoids, and terpenoids. These phytoconstituents may be responsible for the said activities. © 2010 RJPBCS.

Venkatesh P.,P.A. College | Dinakar A.,Sun Institute of Pharmaceutical Education and Research Center | Senthilkumar N.,JKK Munirajah Medical Research Foundation
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

An alcoholic extract of stem and leaves of Boerhaavia Diffusa (AEBD) and leaves of Anisochilus Carnosus (AEAC) was studied for hepatoprotective activity against Carbon Tetrachloride (CCl4) induced hepatotoxicity in rats. Hepatotoxicity was introduced in Albino rats of either sex by intraperitoneal injection of CCl4 (in olive oil). Alcoholic extracts of AEBD and AEAC were administered to the experimental rats at the dose levels 150mg and 300mg/kg body weight, 200mg and 400mg/kg body weight of AEBD and AEAC respectively. The hepatoprotective effects of the extracts were evaluated by the assay of liver function biochemical parameters like Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Tranaminase (SGPT), Serum Alkaline Phosphatase (SALP), Total and Direct Serum Bilirubin. It was concluded that, the alcoholic extracts of AEBD and AEAC possess hepatoprotective activity against CCl4 induced hepatotoxicity in rats.

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