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Davanagere, India

Preethi C.R.,JJM Medical College
Journal of Clinical and Diagnostic Research | Year: 2014

Context: Acute Myeloid leukemia has been of special interest to innumerable workers in the field of cancer research since the blood and haematopoietic tissue can be easily and repeatedly sampled. Aim: To know the relative incidence of Acute myeloid leukemia among the patients referred for complete haemogram at the Department of Pathology, JJMMC, Davangere, India.To study the clinical manifestations and their correlation with various types of acute myeloid leukemia. To study the haematological profiles in acute myeloid leukemia. Settings and Design: This was a hospital based study conducted at haematology unit, Department of Pathology, JJM Medical College, Davangere, India. Materials and Method: The present study was done during the period of June 2006 to May 2008 at haematology unit department of Pathology, JJM Medical College, Davangere, India. Cases from Chigateri General Hospital, Bapuji Hospital and other private hospitals situated in and around Davangere were included for the study. The case selection was based on the clinical features and supported by laboratory evidence. Bone marrow aspiration was subsequently carried out after obtaining written consent from the patient or the guardian. Statistics: The results were expressed in percentage. Results and Conclusion: A total of 1039 patients who were referred to the Department of Haematology out of which 50 patients were diagnosed as Acute Myeloid Leukemia. The present study highlighted that light microscopic features of peripheral smear and bone marrow will still remain mainstay in the diagnosis of acute leukemias.

Antony B.,Fr Muller Medical College | Prasad B.P.M.R.,JJM Medical College
Asian Pacific Journal of Tropical Disease | Year: 2011

Objective: To report an outbreak of Enterobacter cloacae (E. cloacae) in a neonatal intensive care unit of a rural hospital in Karnataka and conduct a prospective study on neonatal septicaemia. Methods: The diagnosis was based on culture, buffy coat smear examination and C-reactive protien test. Results: E. cloacae was isolated from 18 neonates with septicaemic syndrome, of which 8 babies died. Source of infection was found to be the water used to bathe the babies. The strain was multidrug resistant, extended-spectrum beta-lactamase producer and was sensitive only to amikacin and flouroquinolones. Conclusions: Clinical significance of E. cloacae as neonatal pathogen warrants attention of clinicians as well as microbiologists. Breaches in infection control measures should be avoided to prevent such outbreaks. © 2011 Asian Pacific Tropical Medicine Press.

Aradhya G.H.,JJM Medical College
Journal of Clinical and Diagnostic Research | Year: 2013

Introduction: Adolescents form about 20-30% of our population. Like the children of any other ages, adolescents have the so called usual problems and problems which are specific for their age and developmental peculiarities. The present study was undertaken to assess the prevalence of the psycho-social problems of adolescent girls and to counsel the girls with problems or those who were problem prone. Methods: This was a cross-sectional study in which 500 adolescent girls from 6 higher secondary schools were selected via a simple random sampling method. A psychiatrist was consulted before the study was undertaken. A pre-designed profoma was given to be filled up and the data was analyzed later. Results: Sixty percent of the girls were in the age group of 14 to 15 years. Depression was noted in 10 girls (2%), symptoms of anxiety were noted in 5 girls (1%), stuttering and a poor concentration were observed in 10 girls (1% each), 2 girls (0.4%) came from broken families, 5 girls (1%) were suffering from anorexia nervosa, 3 girls (0.6%) were suffering from bulimia nervosa and 10 girls (2%) had pychosomatic symptoms. 5 girls (1%) reported interpersonal violence among their hostelmates. Conclusion: Finding out the prevalence of the psychosocial problems among adolescent girls and counselling them appropriately can decrease the major psychosocial morbidities which are prevalent in the community.

Purpose: To evaluate the efficacy of a combination of 5-fluorouracil (5-FU) and low molecular weight heparin (LMWH) during vitrectomy, as adjuvants in preventing proliferative vitreoretinopathy (PVR). Design: Double-blind, prospective, randomized placebo-controlled trial. Methods: Forty consecutive patients diagnosed with rhegmatogenous retinal detachment with high-risk PVR, were randomized to study and control groups (n = 20 each). Study group (group 1) patients underwent vitrectomy with the use of both intraoperative 5-FU (0.2. mg/ml) and LMWH (5. IU/ml). In the control group (group 2), a similar surgery was performed without the use of adjuvants. Patients were evaluated at 1. month, 3. months and 6. months after surgery. Postoperative retinal reattachment, recurrence of PVR, best-corrected visual acuity and complications at the end of 6. months were compared between the two groups. A Chi-. square statistical analysis was used on all of the outcome measures. Results: At 6months post-surgery, 62.5% of patients had reattached retina. There was no significant difference (Chi-square test showed x2=0.106, P=0.7447, P>0.05) in retinal reattachment in both of the groups. The rate of postoperative PVR in the control group was 55%; in the study group, the rate was 45% (the Chi-square test showed x2=0.4, P=0.5271, P>0.05), which proves statistically insignificant. In addition, there was no statistically significant difference in visual outcomes between the two groups (Chi-square test showed x2=0.1002, P>0.05), no significant difference in the complication rate and drug toxicity was noted between two groups. Conclusions: This study fails to prove the efficacy of the intraoperative use of 5-FU and LMWH in combination as an antiproliferative regiment for the prevention of postoperative PVR or improvement in final visual acuity. At the same time, no significant complications could be attributed to the treatment. © 2014 Saudi Ophthalmological Society, King Saud University.

Usha M.G.,JJM Medical College | Shwetha D.C.,Basaveshwara Medical College | Vishwanath G.,JJM Medical College
Indian Journal of Pathology and Microbiology | Year: 2013

Background: Despite their frequency as contaminants, coagulase-negative Staphylococci (CONS) have become important nosocomial pathogens, accounting for 9% of all nosocomial infections. These infections are difficult to treat because of the risk factors and the multiple drug resistance nature of these organisms. Materials and Methods: One hundred and two consecutive CONS were isolated from various clinical samples like blood, pus, urine, urine catheter tip and gastric lavage. Most of the blood samples were from patients with risk factors (immunocompromised or on medical devices). After confirming the isolates as CONS, species-level identification was performed by simple, non-expensive conventional methods and antibiotic sensitivity testing was also carried out. Results: Of 102 CONS isolates, 100 isolates could be identified to the species level. Among the 100 isolates, epidermidis was the most common species isolated, seen in 32%, followed by S. hemolyticus (18%), S. lugdunensis (12%), S. hominis (10%), S. saprophyticus (8%), S. capitis (6%), S. caprae (4%), S. xylosus (4%), S. cohni and S. warneri (3% each). In the present study, 56% of the isolates were methicillin-resistant CONS. Most of the isolates showed resistance to ampicillin and amoxyclav (89% each), followed by ceftriaxone (52%), cotrimoxazole (46%), cefotaxime (32%), gentamicin (25%), amikacin (21%). Conclusion: The increased pathogenic potential and multiple-drug resistance demonstrates the need to adopt simple, reliable and non-expensive methods for identifying and determining the antibiotic sensitivity of CONS.

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