Gwalior, India
Gwalior, India

Jiwaji University , is an public affiliating university situated in Gwalior, Madhya Pradesh, India. The name comes from that of George Jivajirao Scindia of Gwalior. The university was established on May 23, 1964 and Sarvapelli Radhakrishnan, the President of India, laid the foundation stone of the University Campus on December 11, 1964. It is fully accredited by the Indian government. The University offers affiliation to institutions of higher learning in six districts of Gwalior and Chambal Division: Gwalior, Morena, Bhind, Guna, Shivpuri and Datia. It started with 29 affiliated colleges and now more than 300 colleges are affiliated to it. Wikipedia.


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Jain Rajeev R.,Jiwaji University | Rather J.A.,Jiwaji University
Colloids and Surfaces B: Biointerfaces | Year: 2011

A sensitive electroanalytical method for determination of gemifloxacin in pharmaceutical formulation has been investigated on the basis of the enhanced electrochemical response at multi-walled carbon nanotubes modified glassy carbon electrode in the presence of CTAB. Solubilized system of different surfactants including SDS, Tween-20 and CTAB were taken for the study of electrochemical behaviour of gemifloxacin at modified electrode. The reduction peak current increases in the presence of CTAB while other surfactants show opposite effect. The modified electrode exhibits catalytic activity, high sensitivity, stability and is applicable over wide range of concentration for the determination of gemifloxacin. The mechanism of electrochemical reduction of gemifloxacin has been proposed on the basis of CV, SWV, DPV and coulometeric techniques. The proposed squarewave voltammetric method shows linearity over the concentration range 2.47-15.5 μg/mL. The achieved limits of detection (LOD) and quantification (LOQ) are 0.90. ng/mL and 3.0. ng/mL respectively. © 2010.


Shrivastava S.,Jiwaji University
American Journal of Biochemistry and Biotechnology | Year: 2011

Problem statement: Aluminum (Al) is a trivalent cation found in its ionic form in most kinds of animal tissues and in natural waters everywhere. Approach: It is a potent neurotoxin and has been associated in the pathogenesis of several clinical disorders including Alzheimer's disease. Results: The aim of the study was to demonstrate the protective effect of S-Allyl-Cysteines (SAC) against Al-induced toxicity in rat model on certain biochemical parameters, lipid peroxidation and oxidative stress enzymes of white albino rats. Six rats per group were divided into various treatment groups. Group one rats were given normal saline and served as control group. Group two animals received Al as aluminum nitrate 32.5 mg (i.p.) for the induction of toxicity. Group three to five received different doses of SAC (25, 50 and 100 mg kg -1) for 3 days after 24 h of Al toxicity. Rats were orally administered their respective doses every day for 3 days. Evaluations were made in blood and tissues. The activity of Acetylcholinesterase (AchE) was inhibited in all the parts of brain after Al intoxication. Significant rise were observed the Activities of Serum Transaminases (AST and ALT) after toxicant exposure. The activity of δ-Aminolevulinic acid Dehydratase (ALAD) in blood and δ-Aminolevulinic Acid Synthetase (ALAS) in brain was decreased after Al exposure. Al significant increased cholesterol, triglyceride, creatinine and urea level in serum. TBARS level was significantly higher and GSH content were significantly lower during toxicity. Total and esterified cholesterol in liver, kidney and brain were increased after Al exposure. Histopathological changes in liver, kidney and brain were also recouped with the therapy. Conclusion/Recommendations: Our data proved that SAC which is a bioactive and bioavailable component of garlic has organosulfur compounds which regulates the thiol status of the cell and scavenges free radicals and work as an antioxidant. Thus SAC effectively reduces cognitive dysfunction and oxidative damage induced by Al. © 2011 Science Publications.


Bhadauria M.,Jiwaji University
Evidence-based Complementary and Alternative Medicine | Year: 2012

Carbon tetrachloride (CCl4) is a well-known hepatotoxicant, and its exposure induces hepatorenal injury via oxidative stress and biochemical alterations. This study had been conducted to confirm the protective role of propolis extract on CCl4-induced hepatorenal oxidative stress and resultant injury. Propolis extracts collected from Gwalior district and 24 female Sprague Dawley rats were used for experiment. Animals were exposed to CCl4 (0.15mL/kg, i.p.) for 12 weeks (5 days/week) followed by treatment with propolis extract (200mg/kg, p.o.) for consecutive 2 weeks. CCl4 exposure significantly depleted blood sugar and hemoglobin level and raised the level of transaminases, alkaline phosphatase, lactate dehydrogenase, protein, urea, albumin, bilirubin, creatinine, triglycerides, and cholesterol in serum. Lipid peroxidation was enhanced, whereas GSH was decreased significantly in liver and kidney in CCl4-intoxicated group. Ethanolic extract of propolis successfully prevented these alterations in experimental animals. Activities of catalase, adenosine triphosphatase, glucose-6-phosphatase, acid, and alkaline phosphatase were also maintained towards normal with propolis therapy. Light microscopical studies showed considerable protection in liver and kidney with propolis treatment, thus, substantiated biochemical observations. This study confirmed hepatoprotective potential of propolis extract against chronic injury induced by CCl4 by regulating antioxidative defense activities.


Bhadauria M.,Jiwaji University
Food and Chemical Toxicology | Year: 2012

A study was undertaken to evaluate protective effect of chelating agent, N-(2-hydroxy ethyl ethylene diamine triacetic acid) [HEDTA] with and without propolis against aluminum (Al) induced toxicity in liver, kidney and brain. Toxicity was induced by single administration of aluminum nitrate at a dose of 32.5mg/kg (1/2 of LD 50). HEDTA (20mg/kg, ip), propolis (200mg/kg, po), and combination of HEDTA and propolis, respectively, were administered for 3days after 24h of Al exposure. Significant enhancement in AST, ALT, uric acid, urea, cholesterol, and triglyceride contents was found in serum, whereas albumin was decreased after Al exposure. Hepatic, renal, and neuronal LPO were found significantly increased after Al exposure, whereas it inhibited AChE activity in forebrain, midbrain, and hindbrain. Al significantly reduced the activity of adenosine triphosphatase, superoxide dismutase and catalase and GSH contents in hepatic, renal and nervous tissues. However, individual treatment of HEDTA and propolis restored biochemical parameters towards control but combined treatment of HEDTA and propolis offered better protection in comparison to monotherapy. Combined treatment of HEDTA and propolis preserved histological features, mitigated oxidative stress and improved liver, kidney and brain functions more profoundly. © 2012 Elsevier Ltd.


Jain R.,Jiwaji University | Dhanjai,Jiwaji University
Colloids and Surfaces B: Biointerfaces | Year: 2013

An ultrasensitive electrochemical sensor based on the electrocatalytic properties of nano graphene (nGN) and multiwalled carbon nanotubes (MWCNTs) for the detection of quinidine (QD) in solubilized systems has been developed. This nano graphene-multiwalled carbon nanotube (nGN-MWCNT) composite film modified sensor shows the higher stability and stronger catalytic activity towards oxidation of quinidine and the over-potential decreased significantly compared with the bare glassy carbon electrode (GCE). The electrochemical characterization of the sensor was done by scanning electron microscopy (SEM) and cyclic voltammetry (CV) with working electrode surface area 0.56cm2 and diffusion coefficient 2.15×10-3cm2s-1. Under the optimized conditions, the oxidation peak current of QD is found to be proportional to its concentration in the range of 60ng-50μg with a detection limit of 0.186ng. The sensor was successfully employed for the detection of quinidine in bulk drugs and in its commercial pharmaceutical formulation. © 2013 Elsevier B.V.


Jaiswal B.S.,Jiwaji University
International Journal of Pharma and Bio Sciences | Year: 2012

Solanum torvum Swartz (family: Solanaceae) is commonly known as turkey berry. This plant is found in tropical Africa, Asia and South America. S. torvum, is an important medicinal plant in tropical and subtropical countries is widely used like food and in folk medicine around the world. This aims a comprehensive of the chemical constituents, pharmacological, and clinical uses. A number of metabolites are in good yield and some have been shown to possess useful biological activities belonging mainly to steroid glycosides and saponins, flavonoid, vitamin B group, vitamin C, iron salts and steroidal alkaloids. Extracts and metabolites of this plant, particularly those from leaves and fruits possess useful pharmacological activities. A survey of the literature shows S. torvum is mainly used for the treatment of fever, wounds, tooth decay, reproductive problems and arterial hypertension. Many pharmacological studies have demonstrated the ability of this plant to exhibit Anti-oxidant activity, cardiovascular, immunomodulatory and nephroprotective activity supporting its traditional uses. This review attempts to highlight the available literature on S. torvum with respect to ethnobotany, chemical constituents and summary of various pharmacological activities.


Bhadauria M.,Jiwaji University
Experimental and Toxicologic Pathology | Year: 2010

Protective effect of emodin (1,3,8-trihydroxy-6-methyl anthraquinone), an active compound of Ventilago madraspatana Gaertn., was evaluated against acetaminophen-induced biochemical and histological alterations in rats. Acetaminophen (2 g/kg, po) administration caused significant elevation in the release of serum transaminases, alkaline phosphatase, lactate dehydrogenase, serum bilirubin and serum protein with concomitant decrease in hemoglobin and blood sugar after 24 h of its administration. Toxicant exposure intensified the lipid peroxidation and altered glutathione status, activities of adenosine triphosphatase, acid phosphatase, alkaline phosphatase as well as major cellular constituents i.e., protein, glycogen and total cholesterol in liver and kidney. Treatment of emodin (20, 30 and 40 mg/kg, po) significantly lessened the toxicity by protecting acetaminophen-induced alterations in various blood and tissue biochemical variables after 24 h of its administration. Acetaminophen administration initiated histological damage in liver. Some degree of protection was seen after emodin therapy in a dose-dependent manner. Emodin at doses of 30 and 40 mg/kg effectively reversed toxic events induced by acetaminophen as same as silymarin (50 mg/kg, po). Thus, the study concluded that emodin at a dose of 30 mg/kg (po) possesses optimum hepatoprotective ability against acetaminophen-induced toxicity. © 2009 Elsevier GmbH.


Shrivastava S.,Jiwaji University
Journal of Trace Elements in Medicine and Biology | Year: 2012

Aluminium (Al) is a potent neurotoxin and has together with other metals been suggested to be associated with Alzheimer's disease causality. The current study was carried out to investigate the potential role of N(2-hydroxyethyl) ethylenediamine triacetic acid (HEDTA) and Se in combination against Al induced toxicity. Animals were exposed to Al at a dose of 27. mg/kg/d i.p. for 60 days. HEDTA and Se were administered at a dose of 20. mg/kg/d i.p. and 0.5. mg/kg/d orally, respectively for 7 consecutive days. Induction of oxidative stress was recorded in the brain after Al exposure. Significant decrease was found in the levels of reduced glutathione activities of the enzymes glutathione reductase, glutathione peroxidase, catalase, superoxide dismutase, acetyl cholinesterase, and increased levels were observed in LPO and glutathione-S-transferase activity in brain and serum. These parameters responded positively to therapy with HEDTA, but more pronounced beneficial effects were observed when HEDTA was administered in combination with Se. The combination was effective in reducing the concentration of Al and level of DNA damage. © 2012 Elsevier GmbH.


Chauhan M.,Jiwaji University | Gupta D.C.,Jiwaji University
International Journal of Refractory Metals and Hard Materials | Year: 2014

The ab-initio calculations have been performed to investigate the structural, electronic, elastic and thermo-physical properties of TiN, ZrN and HfN in the stable B1 and high pressure B2 phases. Two different pseudo- and full-potential based approaches have been used in the calculations. The results are in good agreement with the measured data. The elastic constants for the B2 phase of these materials have been calculated for the first time except for ZrN. The observations show that these materials are mechanically stable not only in B1 phase at ambient conditions but also in B2 phase at high pressures. They are brittle in B1 phase while ductile in B2 phase. These materials are anisotropic in both B1 and B2 phases with increased anisotropy in B2 phase. The electronic behaviour of these materials is similar in both B1 and B2 phases except the broadening of the bands in B2 phase. These materials are found to be covalent, ionic and metallic in both the phases concerned. Present observation of electronic nature in CsCl structure of these materials needs validation by future researchers. © 2012 Elsevier B.V. All rights reserved.


Full-potential linear augmented plane wave plus local orbital method employing local spin-density approximation along with Hubbard-U corrections and spin-orbit coupling have been used to study electronic, structural and phase transition properties of NdSb. Under compression, they undergo first-order structural transition from B1 to BCT phase. Computed phase transition pressure is 15.1 GPa, this agrees well with their measured value of 15 GPa. Structural properties viz., equilibrium lattice constants, bulk modulus, its pressure derivative and volume collapse are also in closer agreement with experimental data. Present strategy shows significant impact on energy levels of occupied and unoccupied 4f states in electronic structure of NdSb and provides better description of crystal properties of present system. © 2013 IACS.

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