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Chen Y.,Jiulongpo District Hospital of Traditional Chinese Medicine | Chen Y.,Chongqing University of Posts and Telecommunications | Liu X.,263 Clinical of the General Hospital of Beijing Military Area | Chen M.,Jiulongpo District Hospital of Traditional Chinese Medicine | And 4 more authors.
International Journal of Clinical and Experimental Medicine

Background: Several molecular epidemiological studies have explored the association between G46295A variant of CD192 gene and cervical cancer susceptibility in distinct populations. However, the results are contradic­tory. To provide convincing evidence for the association, we performed the present meta-analysis incorporating all case-control studies. Methods and findings: The Cochrane, Google Scholar and PubMed databases were system­atically searched to identify the potentially relevant studies. Statistical analyses were performed using R software. Crude odds ratio (OR) was calculated to estimate the risk of cervical cancer. Five case-control studies were consid­ered in the final analysis. Using the homozygous, heterogeneous, allele, dominant, and recessive model, we found the association between CD192 G46295A variant and cervical cancer was not statistically significant. Conclusions: This meta-analysis shows that the CD192 G46295A variant may not confer genetic susceptibility towards cervical cancer. © 2015, E-Century Publishing Corporation. All rights reserved. Source

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