JITSUBO Co.

Koganei, Japan

JITSUBO Co.

Koganei, Japan
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Kitada S.,Tokyo University of Agriculture and Technology | Fujita S.,JITSUBO Co. | Okada Y.,Tokyo University of Agriculture and Technology | Kim S.,Tokyo University of Agriculture and Technology | Chiba K.,Tokyo University of Agriculture and Technology
Tetrahedron | Year: 2013

Oxidative disulfide bond formations have been applied to soluble-tag-assisted method successfully to realize the total synthesis of α-conotoxin MII (4) that comprises 16 amino acid residues and possesses 2 disulfide bonds. Orthogonal peptide folding using DEAD and iodine oxidations in combination with Mmt and Acm groups for the side chain protection of cysteines could be carried out with no peptide aggregation. © 2013 Elsevier Ltd. All rights reserved.


Tana G.,Tokyo University of Agriculture and Technology | Kitada S.,Tokyo University of Agriculture and Technology | Fujita S.,JITSUBO Co. | Okada Y.,Tokyo University of Agriculture and Technology | And 2 more authors.
Chemical Communications | Year: 2010

A simple acid-resistant hydrophobic tag, which can be removed rapidly in a single-step procedure after overall peptide synthesis, has been developed to accomplish practical solution-phase synthesis of a 15-mer antagonistic peptide of TNF-α (A-TNF-α). Hydrophobically tagged peptides can be separated as precipitates at each step by addition of a polar organic solvent. © 2010 The Royal Society of Chemistry.


Fujita Y.,Tokyo University of Agriculture and Technology | Fujita S.,JITSUBO Co. | Okada Y.,Tokyo University of Agriculture and Technology | Chiba K.,Tokyo University of Agriculture and Technology
Organic Letters | Year: 2013

A soluble tag-assisted liquid-phase method was successfully applied to peptide head-to-tail cyclization, leading to the total synthesis of antimalarial cyclic heptapeptide, mahafacyclin B (1). The cyclization was carried out in the liquid phase with the tag remaining, which allowed rapid reaction workup and product isolation. © 2013 American Chemical Society.


Patent
JITSUBO Co., Tokyo University of Agriculture and Technology | Date: 2013-12-20

Disclosed are a carrier for use for separation purpose and a method for separation of a compound which enable a chemical reaction to be performed in a liquid phase, enable a compound of interest to be separated from the liquid phase after the completion of the reaction readily, enable the separated compound to be evaluated by structural analysis or the like while the compound being bound to the carrier, and enable the compound to be separated from the carrier readily. A carrier for separation which has a reaction site capable of reacting with other compound on a benzene ring, and a long-chain group having a specified carbon atom(s) at each of the ortho-position and the para-position of the reaction site through an oxygen atom.


A reagent for organic synthesis with which a chemical reaction can be conducted in a liquid phase and unnecessary compound(s) can be easily separated at low cost from the liquid phase after completion of the reaction. The reagent for organic synthesis reversibly changes from a liquid-phase state to a solid-phase state with changes in solution composition and/or solution temperature, and is for use in organic synthesis reactions. This reagent for organic syntheses facilitates process development. With the reagent, research on and development of, e.g., medicines through, e.g., compound library synthesis, etc. can be accelerated. It can hence contribute to technical innovations in the biochemical industry and chemical industry.


The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an NR bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.

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