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Peng L.,JiShuiTan Hospital | Peng L.,University of Chicago | Sun S.,CAS Institute of Botany | Xie L.-H.,UMDNJ | And 3 more authors.
Cardiovascular Therapeutics | Year: 2012

Ginsenosides are the bioactive constituents of ginseng, a key herb in traditional Chinese medicine. As a single component of ginseng, ginsenoside Re (G-Re) belongs to the panaxatriol group. Many reports demonstrated that G-Re possesses the multifaceted beneficial pharmacological effects on cardiovascular system. G-Re has negative effect on cardiac contractility and autorhythmicity. It causes alternations in cardiac electrophysiological properties, which may account for its antiarrhythmic effect. In addition, G-Re also exerts antiischemic effect and induces angiogenic regeneration. In this review, we first outline the chemistry and the pharmacological effects of G-Re on the cardiovascular system. © 2012 Blackwell Publishing Ltd.


Shi X.,CAS Institute of Chemistry | Jiang J.,Jishuitan Hospital | Sun L.,Jishuitan Hospital | Gan Z.,CAS Institute of Chemistry
Colloids and Surfaces B: Biointerfaces | Year: 2011

Poly(lactic acid) (PLA) microspheres have great potential in bone tissue engineering. However, their applications have been limited by surface and bulk properties such as hydrophobicity, lack of cell recognition sites and acidic degradation products. Apatite is a mineral which can effectively promote the adhesion and growth of bone cells. In this study, the bonelike mineral, carbonate apatite, was successfully used to functionalize porous PLA microspheres by a biomimetic mineralization method. To improve apatite formation, porous PLA microspheres were first selectively hydrolyzed in NaOH solution to increase the density of polar anionic groups on the surface, and then immersed in simulated body fluid for biomineralization. The morphology, composition, and phase structure of bioactive mineral grown on the original and hydrolyzed PLA microspheres were analyzed and compared quantitatively. The results showed that the hydrolysis which took place on the PLA microspheres enhanced the nucleation and growth of apatite. MG-63 cells attached well and spread actively on the mineralized PLA microspheres, indicating their strong potential in bone tissue engineering. © 2010 Elsevier B.V.


Shi X.,CAS Institute of Chemistry | Sun L.,Jishuitan Hospital | Gan Z.,CAS Institute of Chemistry
Acta Polymerica Sinica | Year: 2011

Porous polylactide (PLA) microspheres were prepared by means of the modified double emulsion solvent evaporation. The organic solvents with different boiling points and aqueous solubility were used to prepare PLA microspheres with different porous structures. Microspheres prepared with methylene chloride, chloroform and toluene as solvents had the similar homogeneous porous structure, while those microspheres with ethyl acetate as solvent showed a hollow structure with a porous thin shell. The effects of solvent types on porous structure of microspheres were discussed. It was concluded that the removal rate of solvent plays the decisive role in determining the porous structure of microspheres. Accordingly, a formation mechanism of porous microspheres fabricated with different solvents was proposed.


Yi J.,Jishuitan Hospital
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences | Year: 2010

To determine the most suitable concentration of ropivacaine on sciatic nerve blocks with stimulating catheters. Sixty adult patients undergoing surgeries involving the foot and ankle were randomly divided into 3 groups (n=20): The patients in group A were given 0.1% ropivacaine, the patients in groups B and C received 0.125% and 0.15% ropivacaine respectively. We combined ultrasound and nerve stimulators for popliteal sciatic nerve blocks, and then placed stimulating catheters for postoperative analgesia. VAS and adverse effects were monitored 6 h, 12 h, 24 h and 48 h after surgery. The difference of VAS was of significance in statistics 6 h and 12 h postoperation. VAS in Group A at postoperative 6 h and 12 h was significantly higher than that in Groups B and C(P<0.05). The incidence of motor disturbance and limbs numbness in Group C was significantly higher than that in Groups A and B (P<0.05). There was no significant difference in the satisfaction of the three groups (P>0.05). The most suitable concentration of ropivacaine on sciatic nerve blocks with stimulating catheters is 0.125%.


To evaluate the combined tenodesis for long head of bicep tendon lesion with massive rotator cuff tear. From January 2004 to June 2009, 41 patients of long head of bicep tendon lesion with massive rotator cuff tear were treated by arthroscopy. The follow-up period was over 12 months. There were 19 males and 22 females with an average age of 57 ± 11 year old. All patients were treated by arthroscopy with double row technique for rotator cuff tear repair and tenodesis for lesions of long head of bicep tendon. It combined the long head of bicep tendon with anterior edge of rotator cuff. The mean visual analogue scale (VAS) was 5.1 ± 23, the range of forward flexion (100 ± 55)°, external rotation (27 ± 24)° and internal rotation up to T(12) (T(5)-S(1)) level pre-operation on average. The Constant-Merly score was 50 ± 23, the University of California at Los Angeles (UCLA) score 14 ± 6 and the simple shoulder test (SST) score 4.0 ± 2.7 pre-operation on average. The strength of flexed elevation was (17 ± 20)% and strength of elbow flexion (101 ± 16)% versus the other side. All patients healed without any complication. Their outcomes improved significantly (P < 0.01). The mean VAS score improved to 1.5 ± 1.8, forward flexion (155 ± 21)°, external rotation (37 ± 24)° and post-operative internal rotation up to T(10) (T(4)-L(3)) on average. The mean Constant improved to 87 ± 13, mean UCLA 29 ± 5 and mean SST 9.3 ± 2.4. The strength of flexed elevation recovered to (68 ± 21)% post-operation. Significant differences were found in range of motion, VAS, strength and functional score (P < 0.01). No difference was observed for Mayo elbow performance score (MEPS) and elbow flexion strength at pre-operation versus post-operation. The combined tenodesis with double row rotator cuff repair is an effective approach for treating lesion of long head of bicep tendon with massive rotator cuff tear.


Zhang G.Z.,Jishuitan Hospital
Zhongguo gu shang = China journal of orthopaedics and traumatology | Year: 2012

To explore clinical effects of three nonparallel screws in treating femoral neck fractures. From September 2008 and May 2009, 29 patients were treated, including 12 males and 17 females with an average age of 52 years (ranged from 27 to 62 years). Before operation, according to Garden classification system, 2 cases were Garden type II (undisplaced fracture), 18 cases were Garden type III (partial displaced fracture) and 9 cases were Garden type IV (complete displaced fracture). After fracture reduction in operation, Pauwels classification system was used to classify the type, and 12 cases were type II, 17 cases were type III Closed reduction and internal fixation with three non-parallel screws were used to treat. The surgery X-ray and follow-up X-ray were compared to observe whether femoral neck abbreviate and screw exit appeare. Harris scoring was used to evaluate function. All patients were followed-up from 34 to 44 months with an average of 38 months. The mean time of bone union was 7 (ranged, 3 to 12) months. Nonunion occured in 4 cases with Garden IV, and femoral head necrosis occurred in 2 cases. For Harris scoring, two cases with nondisplaced fracture were 100. Among 27 cases with displaced fractures, 23 cases achieved bone union without femoral head necrosis, average Harris scale was 91.35 +/- 8.00, and the average Harris scale of 4 cases with bone nonunion was 61.23 +/- 5.12. For all but one, there was no femoral neck crispation after bone union. Nonparallel screws for femoral neck fractures can effectively control abbreviation and screw tail exit after fracture healing.


Li M.,CAS National Center for Nanoscience and Technology | Li M.,Qingdao University | Liu W.,CAS National Center for Nanoscience and Technology | Sun J.,CAS National Center for Nanoscience and Technology | And 8 more authors.
ACS Applied Materials and Interfaces | Year: 2013

In this work, we fabricated polymeric fibrous scaffolds for bone tissue engineering using primary human osteoblasts (HOB) as the model cell. By employing one simple approach, electrospinning, we produced poly(lactic-co- glycolic acid) (PLGA) scaffolds with different topographies including microspheres, beaded fibers, and uniform fibers, as well as the PLGA/nanohydroxyapatite (nano-HA) composite scaffold. The bone-bonding ability of electrospun scaffolds was investigated by using simulated body fluid (SBF) solution, and the nano-HA in PLGA/nano-HA composite scaffold can significantly enhance the formation of the bonelike apatites. Furthermore, we carried out in vitro experiments to test the performance of electrospun scaffolds by utilizing both mouse preosteoblast cell line (MC 3T3 E1) and HOB. Results including cell viability, alkaline phosphatase (ALP) activity, and osteocalcin concentration demonstrated that the PLGA/nano-HA fibers can promote the proliferation of HOB efficiently, indicating that it is a promising scaffold for human bone repair. © 2013 American Chemical Society.


Zhang J.,Jishuitan Hospital
Zhongguo gu shang = China journal of orthopaedics and traumatology | Year: 2013

To evaluate the effect and complication of surgical treatment for Pilon fracture using the posterolateral approach. From August 2009 to March 2011, 15 patients with Pilon fractures (2 in B3,13 in C) and with a separate displaced posterior malleolar fragment was treated in two-stage: the first stage management was on stabiliztion of the soft tissue envelope with temporary external fixator of spanning arthritis, and the second stage management was open reduction and internal fixation with posterolateral approach and anteromedial or anteralateral approach. All patients were followed-up for 12 to 17 months (14.2 months in average). Thirteen of the 15 fractures healed, but 2 fractures needed autologous bone graft procedure duo to nonuion. There was no wound complication related to poterolateral incion. Fourteen fractures had less than 2 mm of incongruity of distal tibia joint. According to Baired-Jackson criteria, the results were excellent in 2 cases, good in 7, fair in 4, and poor in 2. The posterolateral approach offers direct visualization for the reduction and fixation of the fibula and posterior distal fragment of the tibia Pilon fractures, faciliate the management of this difficult fracture pattern.


Chen H.-L.,Jishuitan Hospital | Deng L.-L.,Jishuitan Hospital | Li J.-F.,Jishuitan Hospital
International Journal of Endocrinology | Year: 2013

This study investigated the prevalence of osteoporosis and its associated factors in old men with T2DM to identify risk factors for low BMD. We enrolled 93 old men (≥60 years of age) with T2DM and 125 healthy old men (controls) and collected data of their lifestyle, medical history, bone densitometry, body weight, height, and blood pressure. Blood samples were collected for biochemical analyses. Urine samples were collected to determine 24 h urinary creatinine, albumin, and protein. Although no differences in age, blood pressure, waist-to-hip ratio, body mass index (BMI), and testosterone levels were observed, the prevalence of low BMD was significantly higher in the T2DM group compared to the control group. The risk of developing low BMD and fracture in T2DM subjects was increased by 46- and 26-fold, respectively, compared to control subjects. BMD of total spine and hip was positively correlated with BMI and negatively correlated with age, duration of diabetes, creatinine, and 24 h urinary albumin. So old men with T2DM have a greater risk of developing low BMD than old men without T2DM. © 2013 Hai-ling Chen et al.


Guo Y.,Jishuitan Hospital | Tian G.L.,Jishuitan Hospital | Chen S.,Jishuitan Hospital | Tapia C.,California Hospital Medical Center
International Orthopaedics | Year: 2014

Purpose: Scaphoid fractures are commonly fixed with headless cannulated screws positioned centrally in the scaphoid. Judgement of central placement of the screw may be difficult. We generated a central zone using computer analysis of 3D reconstructions of computed tomography (CT) images. As long as the screw axis is completely contained within this central zone, the screw would be considered as centrally placed. Methods: Thirty cases of 3D CT reconstructions of normal scaphoids in a computerised operation planning and simulation system (Vxwork software) were obtained. The central zone was established after some distance shrinkage of the original scaphoid surface reconstruction model using the function "erode" in the software. The shape of the central zone was evaluated, and the width of the central zone in the proximal pole, waist portion and distal pole was measured. We also established the long axis of the scaphoid to see whether it stays in the central zone. Results: All central zones could be divided into distal, waist and proximal portions according to the corresponding irregular shape of the scaphoid. As the geometry of the central zone was so irregular and its width very narrow, it was possible to completely contain the screw axis either in the proximal portion alone, waist alone or distal central zone alone. Conclusions: Establishing the central zone of scaphoid 3D CT images provided a baseline for discussion of central placement of a scaphoid screw. The geometry of the scaphoid central zone determined that the screw could hardly be inserted through entire scaphoid central area during surgery. © 2013 Springer-Verlag Berlin Heidelberg.

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