Jiroft University of Medical science

Jiroft, Iran

Jiroft University of Medical science

Jiroft, Iran
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Seyedi F.,Jiroft University of Medical science | Farsinejad A.,Kerman Medical University | Nematollahi-Mahani S.N.,Kerman Medical University | Nematollahi-Mahani S.N.,Afzal Research Institute
Tissue and Cell | Year: 2017

Tissue engineering is a new strategy which proposed to treat numerous human diseases nowadays. Three dimensional (3D) scaffolds fill the gap between two dimensional cell culture (2D) and animal tissues through mimicking the environmental behaviors surrounding the cells. In this study, hUCMs into insulin producing cells in fibrin scaffold were differentiated compare to conventional culture condition. Differentiation rate was estimated by real time PCR, immunocytochemistry (ICC) and the chemiluminesence (CLIA) and enzyme immunoassay (EIA). Real time PCR's results showed an increasing expression in NKX2.2, PDX1 and INS (producing the hormone insulin) genes in fibrin scaffold. Furthermore ICC analysis exhibited that insulin and pro-insulin proteins were more in fibrin scaffolds. CLIA and EIA on insulin and C peptide secretion indicated that both of groups were sensitive to the glucose challenge test but significant higher response was observed in fibrin scaffold (6.5 fold in 3D, 1.8 fold in 2D culture). It could be concluded that differentiation of hUCM cells into insulin producing cells in fibrin scaffold 3D culture system is much more efficient than 2D conventional culture system. © 2017 Elsevier Ltd.


Bagheri P.,Jiroft University of Medical Science | Sepand M.R.,Tehran University of Medical Sciences
Koomesh | Year: 2015

Introduction: Regarding the increasing number of non-food poisoning in Iran and its financial burdens on the health system, a systematic and Meta analytical study of related documents might lead us toward more precise ideas for our future plans and strategies. Materials and Methods: The reviewed articles for this analytical study were included; related subjects in Iranian and international journals, final report of research projects, papers presented at the congresses and thesis review with using standard and sensitive keywords related to the subject. Most of the articles published between1991-2013years with inclusion criteria after quality control using random model, were chosen for Meta-analysis. Results: The findings in this study show the best estimate of the prevalence of intentional non-food poisoning, 46.11% , and accidental non-food poisoning in Iran, 53.88%. The research also found a substantial heterogeneity in using meta regression method. The main causes of this heterogeneity were participants, sample size and average age of the samples. Conclusion: the simple review of national documents show that morbidity and mortality rate produced by different ways of poisonings, still is high in Iran. It seems that the study of the pathological bases of these incidents with the aim of setting the evidence-based policies and with the approach of changing the attitudes and awareness of people more than before, are the most essential subjects in this field of study. © 2015, Semnan University of Medical Sciences. All rights reserved.


Naderi A.,Kerman Medical University | Nikvarz M.,Jiroft University of Medical science | Arasteh M.,Kerman Special Disease Center | Shokoohi M.,Kerman Medical University
Archives of Iranian Medicine | Year: 2012

Background: Types A and B hemophilia are coagulation disorders associated with many complications. Osteoporosis is a skeletal condition characterized by the decreased density of normally mineralized bone. This study aims to determine the relationship between osteoporosis and hemophilic arthropathy in severe hemophilia patients over the age of 20 years in Kerman, Iran. Methods: We performed a cross-sectional study of bone density among 40 male patients with severe hemophilia. Lumbar spine and femoral bone mineral density (BMDs) were measured using a Dual Energy X-ray Absorptiometry (DEXA) scan. The T-scores for BMDs were computed and values from -2.5 to -1 were considered as osteopenia. Those less than -2.5 were considered to be osteoporotic. Results: About 42% of patients had normal BMD, 50% were osteopenic, and the rest were osteoporotic. The mean BMI, number of arthropathic joints, and the numbers of joint bleeding during the previous year were significantly higher in osteoporotic patients than osteopenic and normal groups (P = 0.05, = 0.003 and = 0.011, respectively). The mean for factor replacement, the number of joint bleeding episodes in the past year, and the number of arthropathic joints were significant independent predictors of both spinal and femoral BMD. Their odds ratios (OR) were 1.29 (factor replacement), 1.17 (numbers of joint bleeding episodes), and 1.73 (number of arthropathic joints), which were significant (P < 0.05). Conclusion: Our results suggest that men with severe hemophilia have reduced BMD. Patients at risk are those with signs of hemophilic arthropathy. Because osteoporosis may complicate the future treatment of patients with hemophilia, screening of patients with hemophilic arthropathy for reduction of BMD and preventive therapies is highly recommended.


Lari M.A.,Shiraz University of Medical Sciences | Bagheri P.,Jiroft University of Medical science | Ameli F.,Shiraz University of Medical Sciences
Shiraz E Medical Journal | Year: 2014

Background: Psychological problems have significant associations with HIV-related high-risk behaviors among female sex workers (FSWs).Objectives: The present study aimed to investigate the relationship between mental health and high-risk behaviors among FSWs in Shiraz, Iran.Patients and Methods: This cross-sectional study, conducted from October 2011 to May 2012, used a convenience sampling method to recruit 125 FSWs and 125 control women. After providing informed consent, each participant completed a validated questionnaire (SCL-90-R and high-risk behaviors).Results: In comparison to the control group, the mean age at first sexual relationship was lower among sex workers, and most of them (80.4%) had not used condoms in their most recent sexual intercourse. The mean scores on all subscales of the SCL-90-R were lower in the control group (P < 0.003), whereas psychological symptoms were significantly more prevalent among FSWs. A significant inverse relationship was found between global severity indexes (GSR) scores and use of condom in the most recent sexual intercourse.Conclusions: Considering the association of high-risk behaviors with lower mental health among FSW, psychological interventions are needed in order to prevent high-risk behaviors and HIV transmission. © 2014, Shiraz University of Medical Sciences.


Sarvtin M.T.,Mazandaran University of Medical Sciences | Sarvtin M.T.,Jiroft University of Medical science | Hedayati M.T.,Mazandaran University of Medical Sciences | Shokohi T.,Mazandaran University of Medical Sciences | HajHeydari Z.,Mazandaran University of Medical Sciences
Archives of Iranian Medicine | Year: 2014

Background: Psoriasis is a common chronic and recurrent inflammatory skin disorder characterized by hyper proliferation of keratinocytes and infiltration of T cells, monocytes/macrophages and neutrophils into dermal and epidermal layers of the skin. The prevalence of cardiovascular disorders in these patients is remarkably higher compared to normal individuals, which seems to be associated with the hyperlipidemia. This study was designed and conducted to investigate the serum lipid profile in psoriatic patients and its association with the severity of disease. Materials and Methods: This case-control study was performed on 50 plaque-type psoriasis patients and 50 healthy individuals as control, matched for age and sex. Blood samples were collected after 14 h fasting. Serum triglyceride, cholesterol and lipoproteins were assayed using the standard kit (made by Pars Among Co. Iran). Results: Certain parameters, including serum triglyceride, cholesterol, low density lipoprotein (LDL), and very low density lipoprotein (VLDL), were significantly higher in the case group compared to the controls (P < 0.001), while high density lipoprotein (HDL) was significantly lower in the former (P < 0.001). In addition, there was a significant relationship between severity of psoriasis and serum lipid profile. Conclusion: The results have revealed the higher plasma level of lipids in psoriatic patients. This may elevate the risk of atherosclerosis, particularly cardiovascular disorders. Therefore, from the epidemiological point of view, screening psoriatic patients, particularly those with severe psoriasis, is recommended.


Pilevarzadeh M.,Jiroft University of Medical science | Mashayekhi F.,Jiroft University of Medical science
Biosciences Biotechnology Research Asia | Year: 2015

Critical thinking can lead to the educational progress of the students and improve their learning process. This research aimed to study the effect of critical thinking on the educational progress of nursing university students. This descriptive research has been focused on 110 nursing university students in Iranian Jiroft City. The needed data was collected using demographic questionnaire and California Critical Thinking Skills Questionnaire, and the students' average score of the educational semester was considered as the criterion for the educational progress. The collected data were analyzed using Chi square (X2) test and T test. The mean of the critical thinking score was obtained as 11.49 ± 2.6 and the students' average score of the semester was obtained as 15.78 ± 2.1. The findings showed that there is no statistically significant relationship between the educational progress and the critical thinking (p= 0.61). Considering the results of this research and the learnability nature of the critical thinking skills, we have to attempt to improve these skills in the students.


Pilevarzadeh M.,Jiroft University of Medical science
International Journal of Biomedical Science | Year: 2016

Breast cancer is the most prevalent cancer among Iranian women. Early diagnosis of the disease is vitally important in successful treating of it and reducing its mortality and care-cost burden. In our country, the major causes of mortality and other unfavorable complications of the disease are due to late referring of women. Breast Self -Examination (BSE) is a low-cost, low-risk, self-performed screening, which, according to the evidence from the literature improves the prospects for women’s survival. A content analysis with a qualitative approach was conducted in depth on women through semi-structured (individual and group) interviews. Based on the result analysis, one them related to women’s prospect BSE: Including Fearful feeling, with 2 Sub-themes A: Change body image B: Uncertain future. Training courses on breast cancer and BSE screening program for women (vulnerable poor population) is necessary so as to change their beliefs and culture in order to promote this health behavior. © 2016 Motahare Pilevarzadeh.


PubMed | Mashhad University of Medical Sciences and Jiroft University of Medical science
Type: | Journal: Life sciences | Year: 2016

Renin-angiotensin system has a role in inflammation and also involves in learning and memory. In the present study, the effects of captopril on lipopolysaccharide (LPS) induced learning and memory impairments, hippocampal cytokine levels and brain tissues oxidative damage was investigated.The rats were divided and treated : [1] saline (Control), [2] LPS (1mg/kg), [3-5] 10, 50 or 100mg/kg captopril 30min before LPS. The treatment was started since six days before the behavioral experiments and continued during the behavioral tests (LPS injection two h before each behavioral experiment).Administration of LPS prolonged the escape latency and traveled path to find the platform in Morris water maze (MWM) test (P<0.01-P<0.001) while, shortened the latency to enter the dark compartment in passive avoidance (PA) test (P<0.001). Pretreatment by all doses of captopril improved performances of the rats in MWM (P<0.05-P<0.001) and also prolonged the latency to enter the dark in PA test (P<0.001). LPS also increased IL-6, TNF-, malondialdehyde (MDA) and nitric oxide(NO) metabolites in the hippocampal tissues (P<0.05-P<0.001) which were prevented by captopril (P<0.05-P<0.001). The thiol, superoxide dismutase(SOD) and catalase(CAT) in the hippocampus of LPS group were lower than the control (P<0.001) while, they were enhanced when the aniamls were pretraeted by captopril (P<0.01-P<0.001).The results of present study showed that captopril improved the LPS-induced learning and memory impairments in rats which were accompanied with attenuating hippocampal cytokine levels and improving the brain tissues oxidative damage criteria.


PubMed | Mashhad University of Medical Sciences and Jiroft University of Medical science
Type: Journal Article | Journal: Avicenna journal of phytomedicine | Year: 2016

Inflammation and oxidative stress is considered to have a crucial role in induction of nephropathy. Curcuma longa (C. longa) and Nigella sativa (N. sativa) have anti-inflammatory and antioxidant effects. This study was designed to investigate the effect of mixed hydro-alcoholic extract of N.sativa and C. longa on the oxidative stress induced by Adriamycin (ADR) in rat kidney.The animals were divided into 6 groups: control (CO), ADR, Adriamycin+ Vitamin C (ADR+VIT C), C. longa extract+ Adriamycin (C.LE+ADR), N. sativa extract+ Adriamycin (N.SE+ADR) and C. longa extract+ N. sativa extract + Adriamycin (N.S+C.L+ADR). ADR (5mg/kg) was injected intravenously, whereas VITC (100mg/kg) and extract of C. longa (1000mg/kg) and N. sativa (200mg/kg) were administrated orally. Finally, the renal tissue, urine and blood samples were collected and submitted to measure of redox markers, osmolarity and renal index.The renal content of total thiol and superoxide dismutase (SOD) activity significantly decreased and Malondialdehyde (MDA) concentration increased in Adriamycin group compared to control group. The renal content of total thiol and SOD activity significantly enhanced and MDA concentration reduced in treated-mixed extract of C. longa and N. sativa along with ADR group compared to ADR group. The mixed extract did not restore increased renal index percentage induced by ADR. There also was no significant difference in urine and serum osmolarity between the groups.hydro-alcoholic extracts of N.sativa and C.longa led to an improvement in ADR-induced oxidative stress and mixed administration of the extracts enhanced the aforementioned therapeutic effect.


PubMed | Mashhad University of Medical Sciences, Jiroft University of medical science and Technical and Vocational University
Type: Journal Article | Journal: Avicenna journal of phytomedicine | Year: 2016

Neuroimmune factors contribute on the pathogenesis of sickness behaviors. Nigella sativa (NS) has anti-inflammatory, anti-anxiety and anti-depressive effects. In the present study, the effect of NS hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (LPS) was investigated.The rats were divided into five groups (n=10 in each): (1) control (saline), (2) LPS (1 mg/kg, administered two hours before behavioral tests), (3-5) LPS-Nigella sativa 100 , 200 and 400 mg/kg (LPS-NS 100, LPS-NS 200 and LPS-NS 400, respectively). Open- field (OF), elevated plus maze (EPM) and forced swimming test (FST) were performed.In OF, LPS reduced the peripheral crossing, peripheral distance, total crossing and total distance compared to control (p<0.01- p<0.001). The central crossing, central distance and central time in LPS-NS 100, LPS-NS200 and LPS-NS 400 groups were higher than LPS (p<0.01- p<0.001). In EPM, LPS decreased the open arm entries, open arm time and closed arm entries while increased the closed time compared to control (p<0.001). Pretreatment by NS extract reversed the effects of LPS (p<0.05- p<0.001). In FST, LPS increased the immobility time while, decreased the climbing and active times compared to control (p<0.05- p<0.001). In LPS-NS 100, LPS-NS 200 and LPS-NS 400 groups the immobility time was less while, the active and climbing times were more than those of LPS (p<0.05- p<0.001).The results of the present study showed that the hydro-alcoholic extract of NS reduced the LPS-induced sickness behaviors in rats. Further investigations are required for better understanding the responsible compound (s) and the underlying mechanism(s).

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