Journal of Cancer Research and Therapeutics | Year: 2016
Breast cancer being one of the common cancers has high morbidity and mortality. Despite the conventional treatment, the burden of the disease increases year after year. There is a need for newer drugs that target the different mechanisms in the pathogenesis. The interaction of cyclins with cyclin dependent kinases (CDKs) plays a major role in the abnormal cell cycle in cancer and it is considered to be an important target. Palbociclib is a CDK inhibitor currently approved for the treatment of breast cancer. The preclinical studies with breast cancer lines were sensitive to palbociclib and the clinical trials phase I, phase II (PALOMA 1), and phase III (PALOMA 2, 3, PENTELOPE, PEARL) showed that the drug was efficacious when combined other conventional drugs for breast cancer. Palbociclib was also been tested in various other germ cell tumors, melanoma, multiple myeloma, glioblastoma multiforme etc., The major adverse effect of the drug includes hematological toxicity mainly neutropenia, gastrointestinal adverse effects.
News Article | October 28, 2016
Chesapeake Vein Center and MedSpa is proud to announce that medical director Dr. Surya Challa has received a vascular testing accreditation from the Intersocietal Accreditation Commission (IAC). This allows Dr. Challa to monitor any unhealthy changes to the blood vessels that may lead to future diseases or conditions. For more than 25 years, the IAC has set the standards for quality medical care, and is the premier accreditation agency for venous testing. Their accreditation represents a “seal of approval,” so patients can know that their doctor has the necessary expertise and experience for proper treatment. For approval, a practice must submit to a rigorous review of their daily operations and exhibit dedication to top quality patient care. Vascular testing at Chesapeake Vein Center and MedSpa can help to identify and evaluate developing circulatory problems such as plaque build-up in the arteries, varicose veins, and the formation of blood clots. These factors can lead to life-threatening conditions like strokes and heart disease, making early detection of the utmost importance. “You can’t treat conditions you don’t know about,” says Dr. Challa. “And in some cases early detection really can make all the difference for a healthy recovery.” More than 500,000 lives are lost to heart diseases in the United States each year. With his IAC accreditation Dr. Challa is striving to reduce this number, and help his Chesapeake area patients lead healthy and happy lives. Anyone who is at high risk for heart disease due to genetic or other factors should ask their doctor about receiving vascular testing at Chesapeake. About Dr. Surya Challa Dr. Surya Challa is a well-established Chesapeake and Virginia Beach general surgeon, vein specialist, and cosmetic medical expert. Board-certified in general surgery, a Diplomate of the American Board of Venous and Lymphatic Medicine (ABVLM), Diplomate in Clinical Informatics (ABPM), and a Registered Phlebology Sonographer (RPhS), Dr. Surya Challa graduated from JIPMER Medical College in Pondicherry, India. He relocated to the United States to undergo further surgical training at Maimonides Medical Center in Brooklyn, New York. Dr. Challa also completed a research fellowship in liver cancer surgery at the Memorial Sloan Kettering Cancer Center in New York. After completing his medical training, Dr. Challa worked as a surgeon at Rappahannock General Hospital in Kilmarnock, Virginia, and at Catskill Regional Medical Center in Harris, New York prior to moving to Hampton Roads. Dr. Challa’s work with patients led to his developing a keen interest and specialty in phlebology, the study of veins. He has had extensive exposure to and interest in venous disease. He has been performing varicose vein procedures since 2008 and has performed over two thousand procedures without major complications. His results have been exemplary. In addition, Dr. Challa has been listed in the “Guide to America’s Top Surgeons” 2004-2005 edition and Strathmore’s “Who’s Who Worldwide Honors 2008.” He is a fellow of the American College of Surgeons and member of the American College of Phlebology, American Society for Breast Surgeons, Medical Society of Virginia, and the JIPMER Alumni Association of North America. Dr. Challa lives in the Tidewater area with his wife and sons. His interests include fitness, travel, and music.
Bharadwaj S.K.,JIPMER |
Vishnu Bhat B.,JIPMER
Journal of Tropical Pediatrics | Year: 2012
Objective: To evaluate the efficacy of therapeutic hypothermia (TH) using gel packs in reducing mortality and morbidity in term neonates with HIE and study the associated problems with TH. Methods: Hypoxic ischaemic encephalopathy babies were randomized into TH and control group. Babies in TH group were cooled for first 72 h of birth using cloth covered cooling gel packs to maintain target rectal temperature of 33-34°C. Infants were followed up to 6 months and were assessed using Baroda Developmental Screening Test. Results: There were no significant differences in baseline parameters. TH group showed significant reduction in the combined rate of death or developmental delay at 6 months of age by 21% (8.1% in the TH group vs. 29% in the control, RR 0.28, 95% CI: 0.11-0.70; p = 0.003). Conclusions: TH using gel packs reduces the risk of death or developmental delay at 6 months of age in infants with HIE. © The Author . Published by Oxford University Press. All rights reserved.
Cornea | Year: 2016
PURPOSE:: To report a rare case of concurrent acute retinal necrosis in a patient with iridocorneal endothelial syndrome (ICE). METHODS:: Case report. RESULTS:: A 42-year-old woman showed acute diminution of vision in the right eye. Her fundus examination revealed features of acute retinal necrosis. She had also experienced gradual diminution of vision in her left eye for 5 years. The examination of her left eye revealed corneal edema with mild corectopia and increased intraocular pressure with abnormal endothelium on specular microscopy pointing to a diagnosis of ICE. CONCLUSIONS:: This is a rare case where concurrent acute retinal necrosis and ICE syndrome are present in the same patient, possibly pointing to a common viral etiology causing both entities. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
Mehra S.,JIPMER |
Fritzler M.J.,University of Calgary
Journal of Immunology Research | Year: 2014
Autoantibodies directed to chromatin components date back to the discovery of the LE cell and the LE cell phenomenon circa 1950, and subsequent evidence that major components of that reaction were chromatin components and histones in particular. Over time, immunoassays ranging from ELISA and line immunoassays to more modern bead-based assays incorporated histone and DNA mixtures, purified histones, and purified nucleosomes leading to a more thorough understanding of the genesis and pathogenetic relationships of antibodies to chromatin components in systemic lupus erythematosus and other autoimmune conditions. More recently, interest has focussed on other components of chromatin such as high mobility group (HMG) proteins both as targets of B cell responses and pro-inflammatory mediators. This review will focus on immunoassays that utilize chromatin components, their clinical relationships, and newer evidence implicating HMG proteins and DNA neutrophil extracellular traps (NETs) as important players in systemic autoimmune rheumatic diseases. © 2014 Sonal Mehra and Marvin J. Fritzler.
Fundamental and Clinical Pharmacology | Year: 2015
Atherosclerosis is a multifactorial condition characterized by endothelial injury, fatty streak deposition, and stiffening of the blood vessels. The pathogenesis is complex and mediated by adhesion molecules, inflammatory cells, and smooth muscle cells. Statins have been the major drugs in treating hypercholesterolemia for the past two decades despite little efficacy. There is an urgent need for new drugs that can replace statins or combined with statins. The preclinical studies evaluating atherosclerosis require an ideal animal model which resembles the disease condition, but there is no single animal model which mimics the disease. The animal models used are rabbits, rats, mice, hamsters, mini pigs, etc. Each animal model has its own advantages and disadvantages. The method of induction of atherosclerosis includes diet, chemical induction, mechanically induced injuries, and genetically manipulated animal models. This review mainly focuses on the various animal models, method of induction, the advantages, disadvantages, and the current perspectives with regard to preclinical studies on atherosclerosis. © 2015 Société Française de Pharmacologie et de Thérapeutique.
Agrawal K.,Jipmer |
Cleft Palate-Craniofacial Journal | Year: 2011
Introduction: In developing countries cleft lip and palate (CLP) patients arrive late, and there is a risk of drop out for functionally important palatoplasty after lip repair. Patients may be underweight, anemic, and prone to recurrent infections. Objective: To repair cleft palate at an appropriate time and secondly to avoid the drop out after the first surgery. Protocol: A new surgical protocol has been designed for patients with CLP in whom the cleft palate is first repaired at 6 to 9 months of age or whenever the patient presents at the clinic. The cleft lip is repaired 3 to 6 months after the first surgery. Patients and Results: When cleft lip repair was performed before palate repair (conventional protocol group) in 89 patients with CLP, the median interval between first and second surgery was 290 days. However, when the modified protocol was followed in 330 patients over 13 years, the median interval was 193 days (p < .0002). The reduction in the interval is statistically significant. In eight patients cleft palate fistula encountered after palatoplasty was repaired during cleft lip repair thus avoiding a third surgery. Conclusions: The compliance for two surgeries in CLP has improved. Apart from achieving the main aim of the new protocol, a number of advantages were noticed. The palate repair was easier in the presence of an unrepaired cleft lip. The anterior palate repair was more dependable with reduced incidence of anterior palatal or alveolar fistula.
Niveditha N.,JIPMER |
Brazilian Journal of Infectious Diseases | Year: 2015
Introduction: Appearance of isolated reports of resistance to anti-methicillin-resistant Staphylococcus aureus (MRSA) drugs is worrisome underscoring the need to continuously monitor the susceptibility of clinical MRSA isolates to these drugs. Hence, the present study is conducted to determine the susceptibility of MRSA isolates to various classes of anti-MRSA drugs such as vancomycin (glycopeptide), daptomycin (lipopeptide), tigecycline (glycylcycline), and linezolid (oxazolidinone) to determine the MIC50 and MIC90 values, and to observe MIC creep over a three year period, if any, with respect to these drugs. Methods: A total of 200 isolates of MRSA obtained from clinical specimens were included. MIC was determined by E-test for anti-MRSA antibiotics vancomycin, linezolid, daptomycin, and tigecycline. Non-parametric methods (Kruskal-Wallis and Chi-square test) were used to assess MIC trends over time. In addition, MIC50 and MIC90 values were also calculated. Results: No isolate was found resistant to vancomycin, daptomycin, or linezolid; five isolates were resistant to tigecycline. Seven VISA isolates were encountered with the MIC value for vancomycin of 4. μg/mL. MIC values for vancomycin, tigecycline, linezolid showed a definite increase over a 3-year period which was statistically significant with p-values <0.0001, 0.0032, 0.0242, respectively. When the percentage of isolates with a median MIC value less than or equal to that of the index year was calculated, the change was most striking with vancomycin. The proportion of isolates with higher MIC values was greater in 2014 than 2012 and 2013. Conclusion: MIC creep was notably observed with vancomycin, and to some extent with tigecycline and linezolid. Selection pressure may result in creeping MICs, which may herald the emergence of resistant organisms. © 2015 Elsevier Editora Ltda.
Journal of orthopaedic surgery (Hong Kong) | Year: 2013
We report on 2 patients with congenital insensitivity to pain and anhydrosis. The first one was a 7-month-old boy who presented with non-traumatic, haematogenous septic dislocation of the right elbow with physeal separation of the distal humerus. The second one was a 3-year-old girl suspected to have Job syndrome with an altered immunological profile.
Kumari R.,JIPMER |
Indian Journal of Dermatology, Venereology and Leprology | Year: 2013
There is increasing evidence in support of the interplay of growth hormone (GH), insulin, and insulin-like growth factor-1 (IGF-1) signaling during puberty, which have a causal role in pathogenesis of acne by influencing adrenal and gonadal androgen metabolism. Milk consumption and hyperglycemic diets can induce insulin and IGF-1-mediated PI3K Akt-activation inducing sebaceous lipogenesis, sebocyte, and keratinocyte proliferation, which can aggravate acne. Occurence of acne as part of various syndromes also provides evidence in favor of correlation between IGF-1 and acne.