Jinyong Co.

Gyeonggi, South Korea

Jinyong Co.

Gyeonggi, South Korea

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Nam D.-E.,Kyung Hee University | Kim O.K.,Kyung Hee University | Shim T.J.,Jinyong Co. | Lee J.K.,Health Balance Co. | Hwang K.-T.,Nambu University
Journal of the Korean Society of Food Science and Nutrition | Year: 2014

The object of this study was to investigate the inhibitory effects of chios mastic gum (MG) on gastric acid secretion in an ethanol-induced SD rat model and primary parietal cells. Rats were randomly divided into four groups: Vehicle (normal group), Control (treated with ethanol), MG50 (treated with ethanol and mastic gum at 50 mg/kg b.w), MG100 (treated with ethanol and mastic gum at 100 mg/kg b.w). Groups treated with both MG50 and MG100 showed attenuation of gastric mucosal injury, sub-epithelial loss, hemorrhaging, and gastric juice secretion. We also examined the acidity of gastric juice during gastric injury. Oral administration of both MG50 and MG100 significantly decreased acidity of gastric juice by % and %, respectively. To examine the stimulatory factors related to gastric acid secretion, mRNA expression levels of H2r, M3r, CCK2r, and H+/K+ ATPase were measured by real-time PCR. Compared with a vehicle group, mRNA expression levels of H2r, CCK2r, and H+/K+ ATPase clearly increased in the control group. However, levels of H2r, CCK2r, and H+/K+ ATPase slightly but significantly decreased in MG-treated groups compared with control. Blood level of histamine significantly decreased in MG-treated groups, which indicates the involvement of MG on in histamine-related acid secretion. To identify the mode of action of MG in regulating histamine-related pathways, intracellular level of cAMP and mRNA levels of H2r, M3r, CCK2r, and H+/K+ ATPase were measured in primary parietal cells. While mRNA levels of M3r and CCK2r remained unchanged, levels of H2r and H+/K+ ATPase significantly decreased upon MG treatment. Subsequently, intracellular levels of cAMP decreased. These results suggest that mastic gum has the ability to inhibit gastric acid secretion by regulating a histamine-related pathway. © 2014, Korean Society of Food Science and Nutrition. All rights reserved.


Shim T.J.,Jinyong Co. | Kim J.H.,Jinyong Co. | Lee J.,Kyung Hee University
Journal of the Korean Society of Food Science and Nutrition | Year: 2014

This study investigated the anti-obesity effects of African mango (Irvingia gabonesis, IGOB 131TM) extract in leptin-deficient obese mice. Experimental groups were treated with two different doses of IGOB 131TM (1% and 2% in each AIN93G supplement) for 8 weeks. Treatment of obese mice with both low and high dose of IGOB 131TM significantly reduced body weight gain by 10.9% and 13.3%, respectively, compared to control obese mice. Subcutaneous adipose tissue weight of mice was significantly reduced by 18% by low-dose and 23% by high-dose supplementation. This result was supported by micro-CT analysis around the abdominal regions of mice, indicating that the adipose tissue area and volume were significantly reduced by treatment with IGOB 131TM. Serum levels of triglycerides in the low- and high-dose groups were reduced by 36.5% and 43.8%, respectively, upon treatment with IGOB 131TM, whereas total cholesterol levels were reduced by 31.8% and 35.4%. Interestingly, the serum LDL level decreased upon treatment with IGOB 131TM while the serum level of HDL dramatically increased upon high-dose treatment with IGOB 131TM, resulting in a significant reduction in the LDL to HDL ratio of 59.2%. These results were supported by the expression levels of enzymes and proteins related to lipid metabolism assessed by real-time PCR. There was a significant increase of in adiponectin expression as well as significant decreases in the expression of FAS, LPL, and lipid regulatory transcription factors such as PPAR-γ, C/EBP, and SREBP upon both low- and high-dose IGOB 131TM treatment. However, there was no statistical difference between low- and high-dose treatments. These results suggest that IGOB 131TM is able to regulate the serum lipid profiles by reducing triglyceride and increasing HDL levels as well as regulate expression of lipid metabolic factors, resulting in reduction of a weight gain in leptin- deficient obese mice. © 2014, Korean Society of Food Science and Nutrition. All rights reserved.


Nam D.-E.,Kyung Hee University | Kim O.K.,Kyung Hee University | Shim T.J.,Jinyong Co. | Kim J.H.,Jinyong Co. | Lee J.,Kyung Hee University
Journal of the Korean Society of Food Science and Nutrition | Year: 2014

The inhibitory effects of Boswellia serrata (BW) extracts on degenerative osteoarthritis were investigated in primary-cultured rat cartilage cells and a monosodium-iodoacetate (MIA)-induced osteoarthritis rat model. To identify the protective effects of BW extract against H2O2 (800 μM, 2 hr) in vitro, cell survival was measured by MTT assay. Cell survival after H2O2 treatment was elevated by BW extract at a concentration of 20 μg/mL. In addition, BW extract treatment significantly reduced and normalized the productions of pro-inflammatory factors, nuclear transcription factor κB, cyclooxygenase-2, tumor necrosis factor-α, and interleukin-6 at a concentration of 20 μg/mL. Treatment of chondrocytes with BW extract significantly reduced 5-lipoxygenase activity and production of prostaglandin E2, especially at a concentration of 10~20 μg/mL. For the in vivo animal study, osteoarthritis was induced by intra-articular injection of MIA into knee joints of rats. Consumption of a diet containing BW extract (100 and 200 mg/kg) for 35 days significantly inhibited the development and severity of osteoarthritis in rats. To determine the genetic expression of arthritic factors in articular cartilage, real-time PCR was applied to measure matrix metalloproteinases (MMP-3, MMP-9, and MMP-13), collagen type I, collagen type II, and aggrecan, and BW extract had protective effects at a concentration of 200 mg/kg. In conclusion, BW extract was able to inhibit articular cartilage degeneration by preventing extracellular matrix degradation and chondrocyte injury. One can consider that BW extract may be a potential therapeutic treatment for degenerative osteoarthritis.

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