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Zhang B.-B.,General Hospital of PLA Chengdu Military Area Command | Yin Y.-W.,Chinese PLA General Hospital | Sun Q.-Q.,Jinsong Sanatorium of Beijing Air Force
Gene | Year: 2012

Epidemiological studies have evaluated the association between IL-1β -. 511 C/T polymorphism and duodenal ulcer (DU) risk. However, the results remain conflicting. The aim of this study was to perform a meta-analysis to investigate a more authentic association between IL-1β -. 511 C/T polymorphism and DU. Systematic searches of electronic databases Embase, PubMed and Web of Science as well as hand searching of the references of identified articles and the meeting abstracts were performed. Study selection, data abstraction and study quality evaluation were independently conducted in duplicate. Statistical analyses were performed using software Stata 11.0. The pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were performed. Publication bias was tested by Begg's funnel plot and Egger's regression test. A total of 14 studies including 1887 cases and 2780 controls were included in our final meta-analysis. There was no evidence of significant association between IL-1β -. 511 C/T polymorphism and DU (for T allele vs. C allele: OR. =. 0.93, 95% CI. =. 0.82-1.06; for T/T vs. C/C: OR. =. 0.83, 95% CI. =. 0.64-1.08; for dominant model: OR. =. 0.93, 95% CI. =. 0.80-1.07; and for recessive model: OR. =. 0.87, 95% CI. =. 0.69-1.11). Significant association was found in all genetic models for the PB subgroup and sensitivity analyses. In conclusion, our meta-analysis suggests that there was no evidence of a significant association between IL-1β -. 511 C/T polymorphism and DU with or without . Helicobacter pylori infection, whereas a significant association was found by sensitivity analyses which showed a protective effect of the T allele against DU risk. © 2012 Elsevier B.V. Source


Zhang B.-B.,General Hospital of PLA Chengdu Military Area Command | Liu X.-Z.,Shanghai University | Sun J.,General Hospital of PLA Chengdu Military Area Command | Yin Y.-W.,Chinese PLA General Hospital | Sun Q.-Q.,Jinsong Sanatorium of Beijing Air Force
PLoS ONE | Year: 2013

Background: Epidemiological studies have evaluated the association between tumor necrosis factor α (TNF-α) single nucleotide polymorphisms (SNPs) and duodenal ulcer (DU), but the results remain inconclusive. The aim of this study was to perform a meta-analysis to investigate a more authentic association between TNF-α SNPs and DU. Methods: We performed the meta-analysis by searching PubMed, Embase, and Web of Science databases from the first available year to Sep. 5, 2012. Additionally, checking reference lists from identified articles, reviews, and the abstracts presented at related scientific societies meetings were also performed. All case-control studies investigating the association between TNF-α SNPs and DU risk were included. The association was assessed by odds ratio (OR) with 95% confidence interval (CI). Publication bias was analyzed by Begg's funnel plot and Egger's regression test. Results: A total of sixteen studies reporting TNF-α -308G/A, -1031T/C, -863C/A, -857C/T, and -238G/A polymorphism were included in our final meta-analysis. There was no statistically significant association between -308G/A polymorphism and DU in the overall study population, as well as subgroup analyses by ethnicity, study design, and H. pylori status. As for -1031T/C, -863C/A, -857C/T, and -238G/A, results of our meta-analyses showed no statistical evidence of significant association. Power calculation on the combined sample size showed that the statistical powers were all lower than 80% for all the meta-analyses. Conclusions: The data suggests that there is no statistical evidence of significant association between the studied TNF-α SNPs and DU. However, this conclusion should be interpreted with caution as low statistical powers were revealed by power calculations. In future, larger sample-size studies with homogeneous DU patients and well-matched controls are required. © 2013 Zhang et al. Source


Yin Y.-W.,Chinese PLA General Hospital | Sun Q.-Q.,Jinsong Sanatorium of Beijing Air Force | Hu A.-M.,Chinese PLA General Hospital | Liu H.-L.,Chinese PLA General Hospital | And 2 more authors.
Human Immunology | Year: 2014

It remains controversial regarding the association between toll-like receptor 4 (TLR4) gene Asp299Gly (+896 A/G) polymorphism and myocardial infarction (MI) risk. Thus, a large-scale meta-analysis evaluating the potential association between this gene variant and MI risk is required. PubMed, Embase, Web of Science, CBMdisc, CNKI, and Google Scholar were searched until February 6, 2013. All the statistical tests were performed using Stata 11.0. Nine articles involving 10 studies were included in the final meta-analysis, covering a total of 8299 MI cases and 6849 controls. Overall, no significant association was found between the TLR4 gene Asp299Gly polymorphism and MI risk (G allele vs. A allele: OR. = 0.95, 95% CI. = 0.74-1.22, p= 0.71; G/G vs. A/A: OR. = 1.03, 95% CI. = 0.54-1.98, p= 0.93; G/G vs. A/G. +. A/A: OR. = 1.05, 95% CI. = 0.55-2.03, p= 0.87; G/G. +. A/G vs. A/A: OR. = 0.92, 95% CI. = 0.75-1.13, p= 0.42). In the subgroup analysis based on source of controls, there was also lack of evidence for significant association between the TLR4 gene Asp299Gly polymorphism and MI risk. In summary, the present meta-analysis indicated that the TLR4 gene Asp299Gly polymorphism was not associated with MI risk. © 2013 American Society for Histocompatibility and Immunogenetics. Source


Yin Y.-W.,Chinese PLA General Hospital | Sun Q.-Q.,Jinsong Sanatorium of Beijing Air Force | Wang P.-J.,Chengdu Medical College | Qiao L.,Chinese PLA General Hospital | And 4 more authors.
PLoS ONE | Year: 2014

Background: Several studies have investigated whether the polymorphism in the apolipoprotein A5 (APOA5) is associated with type 2 diabetes mellitus (T2DM) risk. However, those studies have produced inconsistent results. The purpose of this study was to investigate whether the APOA5 -1131T/C polymorphism (rs662799) confers significant susceptibility to T2DM using a meta-analysis. Methods: PubMed, Embase, Web of Science, Cochrane database, CBMdisc, CNKI and Google Scholar were searched to get the genetic association studies. All statistical analyses were done with Stata 11.0. Results: A total of 19 studies included 4,767 T2DM cases and 10,370 controls (four studies involving 555 T2DM cases and 2958 controls were performed among Europeans and 15 studies involving 4212 T2DM cases and 7412 controls were performed among Asians) were combined showing significant association between the APOA5 -1131T/C polymorphism and T2DM risk (for C allele vs. T allele: OR = 1.28, 95% CI = 1.17-1.40, p<0.00001; for C/C vs. T/T: OR = 1.57, 95% CI = 1.35-1.83, p<0.00001; for C/C vs. T/C+T/T: OR = 1.36, 95% CI = 1.18-1.57, p<0.0001; for C/C+T/C vs. T/T: OR = 1.32, 95% CI = 1.16-1.51, p<0.0001). In the subgroup analysis by ethnicity, significant association was also found among Asians (for C allele vs. T allele: OR = 1.31, 95% CI = 1.22-1.40, p<0.00001; for C/C vs. T/T: OR = 1.61, 95% CI = 1.38-1.88, p<0.00001; for C/C vs. T/C+T/ T: OR = 1.39, 95% CI = 1.20-1.61, p<0.0001; for C/C+T/C vs. T/T: OR = 1.42, 95% CI = 1.25-1.62, p<0.00001). However, no significant association was found between the APOA5 -1131T/C polymorphism and T2DM risk among Europeans. Conclusions: The present meta-analysis suggests that the APOA5 -1131T/C polymorphism is associated with an increased T2DM risk in Asian population. © 2014 Yin et al. Source


Yin Y.-W.,Chinese PLA General Hospital | Sun Q.-Q.,Jinsong Sanatorium of Beijing Air Force | Hu A.-M.,Chinese PLA General Hospital | Wang Q.,Chinese PLA General Hospital | Liu H.-L.,Chinese PLA General Hospital
Molecular Genetics and Genomics | Year: 2015

Osteoarthritis (OA) is one of the most common skeletal disease, which seriously affects the quality of life of patients, particularly in the middle-aged and elderly individuals. We aimed to explore whether rs9340799 [estrogen receptor alpha (ER-α) XbaI A/G] polymorphism was associated with OA using a meta-analysis. A literature search for eligible studies published before March 28, 2014 was conducted in the PubMed, Web of Science, Embase, Cochrane database, Current Controlled Trials, Clinicaltrials.gov, Chinese Clinical Trial Registry, CBMdisc, CNKI, Google Scholar and Baidu Library. The association between the rs9340799 polymorphism and OA risk was assessed by odds ratios (ORs) together with their 95 % confidence intervals (CIs). A total of 663 articles were found. After article review and quality assessment, 10 articles involving 2,924 OA cases and 5,868 controls were included in the final meta-analysis. The combined evidence suggested that rs9340799 polymorphism contributed significantly to an increased risk of OA (for G allele vs. A allele: OR = 1.21, 95 % CI 1.03–1.43, p = 0.02; for G/G vs. A/A: OR = 1.30, 95 % CI 1.07–1.57, p = 0.009). In the subgroup analyses, significant associations were found between the rs9340799 polymorphism and the OA risk in the European group, Asian group, and knee osteoarthritis group, respectively. These results suggested that the rs9340799 polymorphism might be associated with the risk of OA. However, the results should be interpreted with caution because of the publication bias. © 2014, Springer-Verlag Berlin Heidelberg. Source

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