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Shenyang, China

Yin M.-D.,Liaoning Cancer Hospital and Institute | Zhao Z.-K.,Jinqiu Hospital | Zhang J.,Liaoning Medical University
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2010

OBJECTIVE: To evaluate the characteristics and application prospect of tissue-engineered blood vessel stent materials. METHODS: Using "tissue engineering, tissue engineering blood vessel, intravascular stent" both in Chinese and English as key words to search documents published between January 1993 and October 2009. Literatures concerning biomaterials and tissue engineered blood vessel were included. Repetitive research or Meta analysis was excluded. After selection, 30 documents were included to discuss the kinds and characteristics of tissue-engineered blood vessel materials. RESULTS: Cellular tissue matrix is a kind of ideal material for intravascular engineering, which had widely applied in tissue-engineered stent. The fibrin-based stents are characterized by good biocompatibility, biodegradation, compatibility, as well as promote vascularization and tissue repair. Gelatin can implement its own "vascularization" due to less antigenicity and can be fully biodegraded. Accordingly, both the natural biomaterials and synthetic polymeric material have certain limitations, thus, the combination of these two materials would construct a tissue-engineered blood vessel stent that has good characteristics. Nano-modified technology is hopeful to be applied in the future transplantation of tissue-engineered blood vessel stent. Conclusion: The tissue-engineered blood vessel developed rapidly in these years. However, as yet, there is not an ideal intravascular stent material. The natural biomaterials arose more attention, but the mechanical function of which is far from the stent requirement. Thus, to reach the aims of repair and reconstruction, new materials are the urgent need in tissue-engineered intravascular stent. Source

Wu B.,Liaoning Medical University | Hao Y.,Jinqiu Hospital | Shi J.,Liaoning Medical University | Geng N.,Liaoning Medical University | And 8 more authors.
Molecular Medicine Reports | Year: 2015

The present study aimed to investigate the association between xanthine dehydrogenase (XDH) gene polymorphism and essential hypertension in the rural Han Chinese population of Fuxin, Liaoning. Han Chinese individuals, who had lived in rural areas of Fuxin, were selected as subjects for the present study. A total of 521 unrelated patients with hypertension were selected, along with a further 533 unrelated individuals with normal blood pressure, in order to serve as controls. Five tag single nucleotide polymorphisms (SNP) of the XDH gene were selected. An estimation of SNP allele frequency was determined using DNA pooling and pyrosequencing methods. Prior to Bonferroni correction, T allele frequency for rs206811 was significantly higher in patients with hypertension, as compared with the controls (64.1 vs. 59.4%; P=0.031); C allele frequency for rs1042039 was significantly higher in patients with hypertension, as compared with the controls (66.1 vs. 60.6%; P=0.011), C allele frequency for rs1054889 was significantly lower in patients with hypertension, as compared with the controls (38.8 vs. 44.8%; P=0.007); and A allele frequency for rs2073316 was significantly lower in patients with hypertension, as compared with the controls (29.2 vs. 34.4%; P=0.013). However, once a Bonferroni correction for multiple testing was applied, the XDH gene polymorphisms rs1042039, rs1054889, and rs2073316 were shown to be associated with hypertension (P=0.044, 0.035, and 0.039, respectively). These results suggest that the XDH gene polymorphisms rs1042039, rs1054889, and rs2073316 may be associated with hypertension in the rural Han Chinese population. Source

Chen X.-M.,Liaoning Medical University | Yang Z.-Y.,Liaoning Medical University | Cui D.-Y.,Jinqiu Hospital | Zhang M.,Jinqiu Hospital
Chinese Journal of Tissue Engineering Research | Year: 2014

Background: Many animal experiments and clinical trials have demonstrated that stem cell transplantation can improve heart function and reduce ventricular dilatation and ventricular remodeling, which has shown an incomparable superiority over traditional therapies in the treatment of myocardial infarction complicated by heart failure. Objective: To observe the clinical effects of single autologous peripheral blood stem cell transplantation in acute myocardial infarction patients with heart failure. Methods: Since 2006 August to 2010 June, 23 patients who were diagnosed to have acute ST elevation myocardial infarction complicated with heart failure were selected and divided into two groups: cell transplantation group (n=11) and control group (n=12). All patients underwent emergency coronary angiography and percutaneous coronary intervention with drug eluting stent implantation. In the stem cell transplantation group, peripheral blood stem cells positive for CD34 (about 1×108) were collected mobilized by granulocyte colony stimulating factor at 5 days after stent implantation, and then the cells were injected into infarcted vessels using coronary angiography method. Two-year follow-up was performed after cell transplantation to observe the cardiac function and adverse reactions in patients. RESULTS AND CONCLUSION: After 6 months of follow-up, the cardiac function in the cell transplantation group was improved significantly compared with that before cell transplantation (P < 0.05), and the left ventricular ejection fraction was increased by (6.2±0.2)% and the left ventricular end diastolic volume was reduced by (4.7±2.9) mm. However, there was no difference in follow-up results by the end of 1 and 2 years after cell transplantation (P > 0.05), as well as no adverse reaction occurred. In the control group, after 6 months of follow-up, the left ventricular ejection fraction was reduced by (0.5±0.1)% and the left ventricular end diastolic volume was increased by (0.4±0.3) mm, which were deteriorated year after year. Percutaneous coronary intervention with autologous peripheral blood stem cell transplantation can significantly improve the left ventricular function, reduce left ventricular volume, and delay or prevent left ventricular remodeling in patients with acute myocardial infarction, which is safe and effective. But up to 2 years after cell transplantation, the cardiac function shows no further improvement. Source

Xing Y.-H.,Jinqiu Hospital | Wei S.,Jinqiu Hospital
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2010

OBJECTIVE: To summarize and analyze the occurrence, prevention and treatment of complications of ischemic cerebrovascular disease following stent implantation. METHODS: We retrieved Science Direct database and Ei database for relevant articles published from January 1960 to October 2009. The key words included "cerebral disease, fracture, stenting" in English. Simultaneously, we retrieved Chinese Journal Full-text Database and Chinese Biomedical Literature Database for relevant articles published from January 1994 to October 2009, with the key words of "cerebrovascular disease, stent implantation, biomaterial" in Chinese. In addition, several relevant literatures were looked up by hand. Studies concerning treatment manners of stent implantation in treatment of cerebrovascular disease were included. RESULTS: Following stent implantation for cerebrovascular disease, common complications contained contrast medium-related complications, such as anaphylactoid reaction, nephrotoxicity, aggravated cardiac load and so on; puncture site complications, such as hematoma, tunica intima laceration-induced secret compartment isolation and severe pelvic cavity bleeding; carotid sinus reflex, such as blood pressure decrease, decreased heart rate, sudden cardiac arrest, even death, serious cardiac arrhythmias and acute myocardial infarction; ischemic stroke; luxury perfusion syndrome, which can induce fatal hemorrhage sometimes; long-term complications, such as restenosis, stent collapse, deformation, displacement and so on. Therefore, protective umbrella technique during surgery can significantly decrease the incidence rate of embolism induced by atherosclerotic plaque desquamation. Transcranial Doppler technique was used during the surgery to promptly find vessel spasm or occlusion. Early application of urokinase and papaverine can lead to complete remission in patients. Intramuscular atropine was utilized to elevate heart rate prior to stent implantation in patients with carotid sinus dysfunction and sinus bradycardia. Following stent implantation, blood volume was enlarged and appropriate pressor agents were taken according to blood pressure.CONCLUSION: During stent implantation for cerebrovascular disease, we can achieve prospective outcomes through making entire diagnostic regulation and operation pre-, in- and post-implantation, promptly finding abnormal condition and effectively managing. Source

Huang Y.,Jinqiu Hospital | Hao Y.-L.,Jinqiu Hospital | Mai X.-Y.,Jinqiu Hospital
Journal of Asian Natural Products Research | Year: 2013

Two new compounds, 8-dehydroxymethylvisanol (1) and 9-O-[3-O-acetyl-β- d-glucopyranosyl]-4-hydroxy-cinnamic acid (4), together with two known lignans, visanol (2) and 9-aldehydevibsanol (3), were isolated from the 80% EtOH extract of Solidago canadensis. The structures of the two new compounds were elucidated on the basis of 1D, 2D NMR, and mass spectral analysis. All the lignans exhibited moderate hypolipidemic activity in high-fat diet-fed hamsters. © 2013 Taylor & Francis Group, LLC. Source

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