Karachi, Pakistan

Jinnah University for Women

Karachi, Pakistan

The Jinnah University for Women , is a private research university located in Karachi, Sindh, Pakistan. It is an all–woman university and is noted as being the first ever women's university in the country.Established as a post-graduate college, its status as full fledged university was upgraded in 1998 the Sindh Assembly. Major financial endowment and funding are managed by the Anjuman-e-Islam Trust. The university offers undergraduate, post-graduate, and doctoral programmes in science, arts, humanities, and general studies. as of 2010, the university is ranked among top institution of higher learning in "general category" by the HEC. Wikipedia.

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Jabeen F.,Jinnah University for Women | Fawwad A.,Baqai Medical University | Rizvi H.A.,Jinnah University for Women | Alvi F.,Baqai Medical University
Pakistan Journal of Medical Sciences | Year: 2013

Objectives: Alteration in platelet morphology and functions are associated with pathological processes and increased risk of vascular complications in patients with diabetes. The purpose of the study was to fnd the correlation between platelet indices with fasting blood glucose, HbA1c and hs-CRP level in pathogenesis of vascular complications in type 2 diabetic patients. Methodology: The study has been carried out on 51 Type 2 Diabetics and 55 age and sex matched healthy control subjects. Fasting blood glucose (FBG), Glycosylated hemoglobin (HbA 1c), high sensitivity C- reactive protein (hs-CRP) level and platelet indices including Platelet count (PLT), Plateletcrit (PCT), Mean platelet volume (MPV), Platelet distribution width (PDW) were estimated and compared with normal subjects. The results were evaluated statistically. Results: The study demonstrated that FBG, HbA1c, MPV, PDW and hs-CRP were statistically higher in diabetics in comparison with control subjects (P is less than 0.05). Positive correlation of FBG with HbA1c (r is equal to 0.993, P is equal to 0.0001), PLT with PCT (r is equal to 0.922, P is equal to 0.0001) and MPV with PDW (r is equal to 0.332, P is equal to 0.024) was found in diabetics. Conclusion: The poor glycemic control is positively correlated with high HbA1c level. The increased values of MPV, PDW and elevated hs-CRP level may also serve as confrmatory test in fnding risk of developing complications.

Wasti A.,Jinnah University for Women | Siddiqui N.A.,Qassim University
Journal of the Pakistan Medical Association | Year: 2010

Objective: To investigate the alterations in different neurotransmitters particularly dopamine and serotonin in various regions of rat brain. Methods: By using HPLC-ECD, the concentration of dopamine, their metabolites (DOPAC, HVA), serotonin, their precursor (tryptophan), and metabolites (5-HIAA) were determined in different regions such as hypothalamus, cortex, midbrain and striatum. In addition, tryptophan pyrrolase enzyme activity and the concentration of tryptophan were also determined in liver samples, following chronic (21 days I/M) treatment of haloperidol and clozapine (of both commercially available and purified form) in an animal model. Results: Significant alterations were observed in the level of neurotransmitters in different regions of rat brain. In response to haloperidol treatment, the level of dopamine was observed to be significantly increased in hypothalamus, cortex and striatum but in midbrain the concentration was slightly decreased, While a significant increase (p<0.05) in the level of serotonin was observed in midbrain, hypothalamus and striatum. However, treatment with clozapine resulted in significant decrease in the level of dopamine in all the regions except cortex; with concurrent decrease observed in serotonin level in all brain regions except cortex where its concentration was slightly increased. Liver demonstrated a significant increase (p<0.05) in the concentration of tryptophan, however, a slight increase was found in the concentration of brain tryptophan following haloperidol treatment. A marked decrease was observed in the concentration of liver tryptophan, whereas, the brain tryptophan concentration is significantly increased (p<0.05) in response to clozapine treatment. Marked increase was observed in the tryptophan pyrrolase enzyme activity, plotted against time at the time interval of 15 minutes in response to both haloperidol and clozapine treatment. Conclusion: We suggest that the varying effect of these drugs on neurotransmitter may account for the difference in the consequence profile in response to chronic treatment (JPMA 60:628; 2010).

Haider S.,Jinnah University for Women | Azmat R.,University of Karachi
Pakistan Journal of Botany | Year: 2012

Lead (Pb)-treated Lens culinaris and Phaseolus mungo seedlings leaves showed considerable reduction in the size with enhance proline and phenol contents while peroxidase and lignin activity was Pb2+ dose dependent. The reduced leaves sizes of both seedlings were correlated with an increase in Pb2+ levels, and activities of peroxidase and lignin deposition in it. The intensification of activities of peroxidase and phenol in the Pb2+ treated plants were accompanied by an increase in the biosynthesis of the lignin contents as their function is of scavenging ROS radical. A strong correlation (r2=0.8570) was observed between Pb2+ and lignin deposition in the Lens culinaris whereas it was non-significant in Phaseolus mungo (r2=0.466). Increased in the lignin contents in the Lens culinaris as a chemical adaptation of the cell walls of various leaves tissues for endurance while decrease in the lignin contents in Phaseolus mungo at high dose of Pb2+may be attributed with the decline in the peroxidase activity. Investigations revealed that although plants adopt several biochemical strategies for their survival but toxicity of Pb2+was significant due to which plant fails to continue in stay alive.

Azmat R.,University of Karachi | Riaz S.,Jinnah University for Women
Pakistan Journal of Botany | Year: 2012

This study was planned to explore the effect of Cu on polymerization of glucose into carbohydrate under Cu stress in seedlings of 15 day old Vigna radiata in relation with photosynthetic pigments. Copper is an important trace metal in carbohydrate metabolism, it effects on the sugar contents when in excess. The interaction of Cu with photo-inhibitory and sugar metabolism showed a direct relation in between carbohydrate metabolism and photosynthesis. A decrease in glucose contents may be attributed with Cu toxicity which inhibits the fixation of CO2 that in turns related with formation of first organic complex. A drastic decrease in carbohydrate contents may be related with Cu interference in polymerization of glucose into carbohydrates. Relative growth rate (RGR) and leaf mass ratio (LMR) of stressed plants were significantly lower than that of control plants. Copper was shown to restrain the growth of the seedlings as it is most important immobile micronutrient that inhibits new root growth. A radical disorder in soluble reducing and non reducing sugars like, glucose, sucrose, total soluble sugars and carbohydrate with decrease in chloroplast pigments can be associated with reduction in leaf photosynthesis and also growth reduction is more likely due to a reduction in whole plant leaf area. Reduced leaf expansion with reduced photosynthetic activity may be related with fewer K contents in seedlings which play a crucial role in leaf expansion.

Badar R.,Jinnah University for Women | Qureshi S.A.,University of Karachi
Journal of Applied Pharmaceutical Science | Year: 2012

The present study was designed to investigate the combine effectof Trichoderma hamatum and host-specific Rhizobium sp. of Vigna mungo on growth and biochemical parameters of same legume. The results proved that T.hamatum and host-specific Rhizobium sp are compatible with each other and their combine use was found effective not only in improving the growth parameters including lengths of roots & shoots and fresh biomass of experimental crop but also increasing the total chlorophyll, carbohydrate and crude protein contents as compared to control plants (p<0.05). Similarly, the amount of both nitrogen and phosphorus was significantly increased in leaves of the same legume (p<0.05). Therefore, T.hamatum could be a good alternate of chemical fertilizer and fungicide for improving the growth and productivity of V.mungo.

Jamil S.,Jinnah University for Women | Siddiq A.,University of Karachi
Journal of Applied Pharmaceutical Science | Year: 2012

The purpose of the present study is to compare the extent of cardiovascular atherosclerotic risk associated with the lipid metabolism in women using hormonal contraceptives in urban population of low socio-economic group. Type of Study was cross sectional. Fifty-four young females of age ranging from 26-32 years maintained on Oral contraceptives (OC), Depo-medroxy progesterone (DMPA), Norethisterone (NET-EN), Implant and non hormonal intrauterine contraceptive device (IUCD) for at least one year were invited. Fasting blood samples were collected for the analysis of lipid parameters. Castelli indices I & II were also calculated to determine the CVD risk. All the results were entered in MS-Excel and mean ± standard deviation was calculated for each frequency. The result of Castelli indices showed that the use of OCs was associated with the highest atherogenic index followed by NET-EN, IUCD, DMPA and implant. The CVD risk may also be attributable to other life style factors as it was not drastically different among hormonal and non hormonal users. Though the risk in this group of young females maintained on contraceptives was found to be minimized because of good monitoring but continuation of hormonal methods might cause this slight predisposition to sub clinical CVD into a well defined atherosclerotic disease later in their lives. It is therefore recommended to use such methods under close monitoring and over the counter use of hormonal contraceptives should be discouraged.

Askari S.,Jinnah University for Women | Azmat R.,University of Karachi
Pakistan Journal of Botany | Year: 2013

Seaweeds are the fascinating groups of marine plants gorging enormous important micro and macro nutrients. Due to their ability to concentrate minerals and trace elements from the sea, render them a potent source of nutrients for crop farming. This article discusses the credible of the green seaweed Codium iyengrii to concentrate non-essential trace element mercury (Hg). The plants were cultivated in randomized block design, exposed to varying concentrations of Hg in the soil separately and simultaneously with seaweeds. It was found that Hg damages the upper epidermal layer of leaves trait. Application of dry seaweeds powder in the Hg contaminated soil showed a repairing condition of epidermal layer of leaves. The role of epidermal layer on leaf surface is important because it protect internal tissues of leaves, involves in exchange of gases and transpiration through stomata. A direct relation between stomatal density and water contents due to the accumulation of Hg in epidermal layer was accountable for photosynthetic destruction. While repairing of leaves with substantial enrichment in % germination, relative water contents (RWC), plant growth with respect to length, biomass, and in opening and closing of stomata in seaweed amended Hg contaminated plants. Scan electron microscopy (SEM) was used to verify the results of Phase contrast microscopy.

Riaz B.,Jinnah University for Women | Khatoon H.,Jinnah University for Women
Journal of Applied Pharmaceutical Science | Year: 2013

The purpose of this study is to rationalize the use of cephalosporins in various common bacterial infections like infections of upper and lower respiratory tract, urinary tract, gastro- intestinal tract and of soft tissues in pediatrics (age range: neonate-10 yrs). A retrospective study was carried out at multiple hospitals in the premises of Karachi. Not less than 150 prescriptions from pediatric ward were collected over a period of a month to evaluate the prescriptions for their rational approach. The prescriptions included in the study were from qualified doctors. Results showed that out of total prescriptions containing antimicrobial therapy collected from pediatric wards, 88.1% prescriptions contained cephalosporins, among which 1st generation cephalosporin 3.93%, 2nd generation cephalosporin 10.23% and 3rd generations cephalosporins 75% were observed. There is an urgent need to develop standards of antimicrobial drug prescriptions to avoid drug resistance. © 2013 Bushra Riaz and Humera Khatoon.

Azmat R.,Jinnah University for Women | Khan N.,Jinnah University for Women
Pakistan Journal of Botany | Year: 2011

The possible involvement of Cu on N - metabolism in relation with protease activity, proline, amino acid contents and protein oxidation was observed. These were monitored as bio-indicators in the seedlings of Vigna radiata treated with (0-25 ppm) CuSO4 to ascertain the role of Cu in generation of oxidative stress. Copper is an essential nutrient element for the plant growth, may be toxic when in excess by their participation in redox cycles producing hydroxyl radicals (·OH) which are extremely toxic to the living cells. Cu produced a significant inhibition of growth as well as a reduction in the water contents in the roots and the leaves of the seedlings. Results showed an increase in the protease activity and decrease in the protein contents, which may be attributed with the plant defense against metal toxicity through hydrolysis of the oxidative proteins. An inverse relation between protease activity and other nitrogen compound showed the effective hydrolyzing role of protease due to which decrease in proline and total amino acid contents were observed, exhibited the highest sensitivity to excess metal, followed by the plant dry weight accumulation, leaf area formation. Decrease in proline contents support the sensitivity of Vigna radiata and weak defense of species against Cu stress.

Tariq Z.,Jinnah University for Women | Arif R.,Jinnah University for Women
International Journal of Security and its Applications | Year: 2014

As this era is known as Electronic era where everything is associated with Internet and its growing number of security threats. In our study, we focused on three different e-mail account securities, comparatively. First, by performing an analysis on online E-mail service providers we concluded that what type of functionalities they are providing to secure their user's information. Second, we categorized users in to three types and on the basis of that we study on user's view on online security, confidence and usability on their E-mail service provider. Third, we evaluate the outcome of our study which emphasizes the user's precautions from protecting their accounts from unauthorized access. The goal is to analyze how users perceive the security of their email account based on the domain in which it was created. We will start by examining different free email providers based on their security and perform a comparison of their features. Then will follow a risk assessment of the information security system as perceived by some students and business users. The reality analysis will allow us to examine and possibly classify the email providers based on their security parameters and users account protection levels. A final comparison will then be made between the results of the reality and the perception analysis to put in evidence their differences and similarities. © 2014 SERSC.

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