Karachi, Pakistan

Jinnah University for Women

Karachi, Pakistan

The Jinnah University for Women , is a private research university located in Karachi, Sindh, Pakistan. It is an all–woman university and is noted as being the first ever women's university in the country.Established as a post-graduate college, its status as full fledged university was upgraded in 1998 the Sindh Assembly. Major financial endowment and funding are managed by the Anjuman-e-Islam Trust. The university offers undergraduate, post-graduate, and doctoral programmes in science, arts, humanities, and general studies. as of 2010, the university is ranked among top institution of higher learning in "general category" by the HEC. Wikipedia.

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Bano N.,Ziauddin University | Najam R.,University of Karachi | Qazi F.,Jinnah University for Women
International Journal of Pharmaceutical Sciences Review and Research | Year: 2013

The purpose of the review is to consolidate the reported risk of cardiotoxicity in patients treated with cisplatin based chemotherapy. Cisplatin can induce direct myocardial toxicity leading to atrial fibrillation whereas the potential of myocardial toxicity is amplified when the drug is administered in combination with other cardiotoxic agents. Chemotherapy with cisplatin can alter endothelial cell integrity and induce spasm, whereas antiangiogenic activity of cisplatin has also been reported. Elevated levels of endothelia and inflammatory marker proteins are measured in the plasma of the patient years later after the therapy. Delayed toxicity associated with cisplatin comprises of hypertension, elevated cholesterol levels, increased BMI and cardiovascular events. This review summarizes the adverse cardiac manifestations of cisplatin reported in previous studies and shows that the remarkable therapeutic benefit of cisplatin may be temporized with substantial risk of cardiovascular morbidity posing a greater threat than the relapse of cancer itself.

Naveed S.,Jinnah University for Women | Uroog S.,Jinnah University for Women | Waheed N.,Jinnah University for Women
International Journal of Current Pharmaceutical Review and Research | Year: 2015

Moxifloxacin is the wide range antibiotic effective against the (-ve) bacteria and (+ve) bacteria .The forced degradation studies conducted for the determination of degradation of durg product. According to ICH guide line moxifloxacin exposed to different condition. Degradation amount of the drug product can be calculated with the help of UV spectrophotometer. According to USP /BP the official test limits should not less then ( %) and should not more then (%). On exposure to acidic and basic medium of avelox ,izilone and Moxiget the forced degradation studies conducted . Observed negligible difference in availability on exposure to UV and heat during the forced degradation studies of the drug substance. This method is simple, less time consuming and cost effective. For the simultaneous quantitative analysis of the Avelox, izilone and Moxiget this method also can be successfully employed.

Naveed S.,Jinnah University for Women | Waheed N.,Jinnah University for Women | Nazeer S.,Jinnah University for Women
Journal of Bioequivalence and Bioavailability | Year: 2014

Metronidazole (MTZ) is a 5-nitroimidazole semi-synthetic compound. MTZ is antiamoebic, anti protozoal and antibacterial, anti parasitic and anti trichomonal agents. It has wide range of activity against anaerobic bacteria as gram negative, gram positive bacilli and cocci, certain capnophilic organisms, protozoa and parasites. It is indicated in infections caused by Helicobacter pylori, acne rosacea, anaerobic infections, parasitic infections, pseudomembranous colitis and Crohn’s disease. ICH guidelines states the parameters which causes forced degradation of a drug product includes Time, Temperature and/ or with humidity, Acid/base Stress testing, photo degradation and pH variation (high and low). Ultraviolet-visible spectroscopic process was developed to analyze and calculate the amount of drug in the presence of degradation products. According to the USP, the official assay limit of the content should NLT 90% and NMT 110% of labeled amount of metronidazole. When active of metronidazole and different brands (FGL, MNE, KNT) exposed to acidic medium of 1N HCl FGL, MNE and KNT show heavy degradation whereas as active MTZb didn’t show any degradation. When active of metronidazole and FGL, MNE, KNT exposed to basic medium i.e. 1N NaOH, FGL show moderate degradation, MNE and KNT shows slight degradation whereas as active didn’t show any degradation. FGL, MNE, KNT and ND MTZb when subjected to heat none of them show degradation. When MTZb, FGL, MNE and KNT subjected to UV light, MTZb exhibit heavy degradation whereas FGL, MNE and KNT exhibit no degradation. UV-Vis spectroscopy is a simple, rapid, cost effective, useful and fruitful method for determination of MTZ in their active and pharmaceutical dosage form (tablets) of different brands. © 2014 Naveed S.

Azmat R.,University of Karachi | Riaz S.,Jinnah University for Women
Pakistan Journal of Botany | Year: 2012

This study was planned to explore the effect of Cu on polymerization of glucose into carbohydrate under Cu stress in seedlings of 15 day old Vigna radiata in relation with photosynthetic pigments. Copper is an important trace metal in carbohydrate metabolism, it effects on the sugar contents when in excess. The interaction of Cu with photo-inhibitory and sugar metabolism showed a direct relation in between carbohydrate metabolism and photosynthesis. A decrease in glucose contents may be attributed with Cu toxicity which inhibits the fixation of CO2 that in turns related with formation of first organic complex. A drastic decrease in carbohydrate contents may be related with Cu interference in polymerization of glucose into carbohydrates. Relative growth rate (RGR) and leaf mass ratio (LMR) of stressed plants were significantly lower than that of control plants. Copper was shown to restrain the growth of the seedlings as it is most important immobile micronutrient that inhibits new root growth. A radical disorder in soluble reducing and non reducing sugars like, glucose, sucrose, total soluble sugars and carbohydrate with decrease in chloroplast pigments can be associated with reduction in leaf photosynthesis and also growth reduction is more likely due to a reduction in whole plant leaf area. Reduced leaf expansion with reduced photosynthetic activity may be related with fewer K contents in seedlings which play a crucial role in leaf expansion.

Badar R.,Jinnah University for Women | Qureshi S.A.,University of Karachi
Journal of Applied Pharmaceutical Science | Year: 2012

The present study was designed to investigate the combine effectof Trichoderma hamatum and host-specific Rhizobium sp. of Vigna mungo on growth and biochemical parameters of same legume. The results proved that T.hamatum and host-specific Rhizobium sp are compatible with each other and their combine use was found effective not only in improving the growth parameters including lengths of roots & shoots and fresh biomass of experimental crop but also increasing the total chlorophyll, carbohydrate and crude protein contents as compared to control plants (p<0.05). Similarly, the amount of both nitrogen and phosphorus was significantly increased in leaves of the same legume (p<0.05). Therefore, T.hamatum could be a good alternate of chemical fertilizer and fungicide for improving the growth and productivity of V.mungo.

Jamil S.,Jinnah University for Women | Siddiq A.,University of Karachi
Journal of Applied Pharmaceutical Science | Year: 2012

The purpose of the present study is to compare the extent of cardiovascular atherosclerotic risk associated with the lipid metabolism in women using hormonal contraceptives in urban population of low socio-economic group. Type of Study was cross sectional. Fifty-four young females of age ranging from 26-32 years maintained on Oral contraceptives (OC), Depo-medroxy progesterone (DMPA), Norethisterone (NET-EN), Implant and non hormonal intrauterine contraceptive device (IUCD) for at least one year were invited. Fasting blood samples were collected for the analysis of lipid parameters. Castelli indices I & II were also calculated to determine the CVD risk. All the results were entered in MS-Excel and mean ± standard deviation was calculated for each frequency. The result of Castelli indices showed that the use of OCs was associated with the highest atherogenic index followed by NET-EN, IUCD, DMPA and implant. The CVD risk may also be attributable to other life style factors as it was not drastically different among hormonal and non hormonal users. Though the risk in this group of young females maintained on contraceptives was found to be minimized because of good monitoring but continuation of hormonal methods might cause this slight predisposition to sub clinical CVD into a well defined atherosclerotic disease later in their lives. It is therefore recommended to use such methods under close monitoring and over the counter use of hormonal contraceptives should be discouraged.

Askari S.,Jinnah University for Women | Azmat R.,University of Karachi
Pakistan Journal of Botany | Year: 2013

Seaweeds are the fascinating groups of marine plants gorging enormous important micro and macro nutrients. Due to their ability to concentrate minerals and trace elements from the sea, render them a potent source of nutrients for crop farming. This article discusses the credible of the green seaweed Codium iyengrii to concentrate non-essential trace element mercury (Hg). The plants were cultivated in randomized block design, exposed to varying concentrations of Hg in the soil separately and simultaneously with seaweeds. It was found that Hg damages the upper epidermal layer of leaves trait. Application of dry seaweeds powder in the Hg contaminated soil showed a repairing condition of epidermal layer of leaves. The role of epidermal layer on leaf surface is important because it protect internal tissues of leaves, involves in exchange of gases and transpiration through stomata. A direct relation between stomatal density and water contents due to the accumulation of Hg in epidermal layer was accountable for photosynthetic destruction. While repairing of leaves with substantial enrichment in % germination, relative water contents (RWC), plant growth with respect to length, biomass, and in opening and closing of stomata in seaweed amended Hg contaminated plants. Scan electron microscopy (SEM) was used to verify the results of Phase contrast microscopy.

Riaz B.,Jinnah University for Women | Khatoon H.,Jinnah University for Women
Journal of Applied Pharmaceutical Science | Year: 2013

The purpose of this study is to rationalize the use of cephalosporins in various common bacterial infections like infections of upper and lower respiratory tract, urinary tract, gastro- intestinal tract and of soft tissues in pediatrics (age range: neonate-10 yrs). A retrospective study was carried out at multiple hospitals in the premises of Karachi. Not less than 150 prescriptions from pediatric ward were collected over a period of a month to evaluate the prescriptions for their rational approach. The prescriptions included in the study were from qualified doctors. Results showed that out of total prescriptions containing antimicrobial therapy collected from pediatric wards, 88.1% prescriptions contained cephalosporins, among which 1st generation cephalosporin 3.93%, 2nd generation cephalosporin 10.23% and 3rd generations cephalosporins 75% were observed. There is an urgent need to develop standards of antimicrobial drug prescriptions to avoid drug resistance. © 2013 Bushra Riaz and Humera Khatoon.

Azmat R.,Jinnah University for Women | Khan N.,Jinnah University for Women
Pakistan Journal of Botany | Year: 2011

The possible involvement of Cu on N - metabolism in relation with protease activity, proline, amino acid contents and protein oxidation was observed. These were monitored as bio-indicators in the seedlings of Vigna radiata treated with (0-25 ppm) CuSO4 to ascertain the role of Cu in generation of oxidative stress. Copper is an essential nutrient element for the plant growth, may be toxic when in excess by their participation in redox cycles producing hydroxyl radicals (·OH) which are extremely toxic to the living cells. Cu produced a significant inhibition of growth as well as a reduction in the water contents in the roots and the leaves of the seedlings. Results showed an increase in the protease activity and decrease in the protein contents, which may be attributed with the plant defense against metal toxicity through hydrolysis of the oxidative proteins. An inverse relation between protease activity and other nitrogen compound showed the effective hydrolyzing role of protease due to which decrease in proline and total amino acid contents were observed, exhibited the highest sensitivity to excess metal, followed by the plant dry weight accumulation, leaf area formation. Decrease in proline contents support the sensitivity of Vigna radiata and weak defense of species against Cu stress.

Tariq Z.,Jinnah University for Women | Arif R.,Jinnah University for Women
International Journal of Security and its Applications | Year: 2014

As this era is known as Electronic era where everything is associated with Internet and its growing number of security threats. In our study, we focused on three different e-mail account securities, comparatively. First, by performing an analysis on online E-mail service providers we concluded that what type of functionalities they are providing to secure their user's information. Second, we categorized users in to three types and on the basis of that we study on user's view on online security, confidence and usability on their E-mail service provider. Third, we evaluate the outcome of our study which emphasizes the user's precautions from protecting their accounts from unauthorized access. The goal is to analyze how users perceive the security of their email account based on the domain in which it was created. We will start by examining different free email providers based on their security and perform a comparison of their features. Then will follow a risk assessment of the information security system as perceived by some students and business users. The reality analysis will allow us to examine and possibly classify the email providers based on their security parameters and users account protection levels. A final comparison will then be made between the results of the reality and the perception analysis to put in evidence their differences and similarities. © 2014 SERSC.

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