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Karachi, Pakistan

The Jinnah University for Women , is a private research university located in Karachi, Sindh, Pakistan. It is an all–woman university and is noted as being the first ever women's university in the country.Established as a post-graduate college, its status as full fledged university was upgraded in 1998 the Sindh Assembly. Major financial endowment and funding are managed by the Anjuman-e-Islam Trust. The university offers undergraduate, post-graduate, and doctoral programmes in science, arts, humanities, and general studies. as of 2010, the university is ranked among top institution of higher learning in "general category" by the HEC. Wikipedia.

Wasti A.,Jinnah University for Women | Siddiqui N.A.,Qassim University
Journal of the Pakistan Medical Association | Year: 2010

Objective: To investigate the alterations in different neurotransmitters particularly dopamine and serotonin in various regions of rat brain. Methods: By using HPLC-ECD, the concentration of dopamine, their metabolites (DOPAC, HVA), serotonin, their precursor (tryptophan), and metabolites (5-HIAA) were determined in different regions such as hypothalamus, cortex, midbrain and striatum. In addition, tryptophan pyrrolase enzyme activity and the concentration of tryptophan were also determined in liver samples, following chronic (21 days I/M) treatment of haloperidol and clozapine (of both commercially available and purified form) in an animal model. Results: Significant alterations were observed in the level of neurotransmitters in different regions of rat brain. In response to haloperidol treatment, the level of dopamine was observed to be significantly increased in hypothalamus, cortex and striatum but in midbrain the concentration was slightly decreased, While a significant increase (p<0.05) in the level of serotonin was observed in midbrain, hypothalamus and striatum. However, treatment with clozapine resulted in significant decrease in the level of dopamine in all the regions except cortex; with concurrent decrease observed in serotonin level in all brain regions except cortex where its concentration was slightly increased. Liver demonstrated a significant increase (p<0.05) in the concentration of tryptophan, however, a slight increase was found in the concentration of brain tryptophan following haloperidol treatment. A marked decrease was observed in the concentration of liver tryptophan, whereas, the brain tryptophan concentration is significantly increased (p<0.05) in response to clozapine treatment. Marked increase was observed in the tryptophan pyrrolase enzyme activity, plotted against time at the time interval of 15 minutes in response to both haloperidol and clozapine treatment. Conclusion: We suggest that the varying effect of these drugs on neurotransmitter may account for the difference in the consequence profile in response to chronic treatment (JPMA 60:628; 2010).

Azmat R.,University of Karachi | Riaz S.,Jinnah University for Women
Pakistan Journal of Botany | Year: 2012

This study was planned to explore the effect of Cu on polymerization of glucose into carbohydrate under Cu stress in seedlings of 15 day old Vigna radiata in relation with photosynthetic pigments. Copper is an important trace metal in carbohydrate metabolism, it effects on the sugar contents when in excess. The interaction of Cu with photo-inhibitory and sugar metabolism showed a direct relation in between carbohydrate metabolism and photosynthesis. A decrease in glucose contents may be attributed with Cu toxicity which inhibits the fixation of CO2 that in turns related with formation of first organic complex. A drastic decrease in carbohydrate contents may be related with Cu interference in polymerization of glucose into carbohydrates. Relative growth rate (RGR) and leaf mass ratio (LMR) of stressed plants were significantly lower than that of control plants. Copper was shown to restrain the growth of the seedlings as it is most important immobile micronutrient that inhibits new root growth. A radical disorder in soluble reducing and non reducing sugars like, glucose, sucrose, total soluble sugars and carbohydrate with decrease in chloroplast pigments can be associated with reduction in leaf photosynthesis and also growth reduction is more likely due to a reduction in whole plant leaf area. Reduced leaf expansion with reduced photosynthetic activity may be related with fewer K contents in seedlings which play a crucial role in leaf expansion.

Haider S.,Jinnah University for Women | Azmat R.,University of Karachi
Pakistan Journal of Botany | Year: 2012

Lead (Pb)-treated Lens culinaris and Phaseolus mungo seedlings leaves showed considerable reduction in the size with enhance proline and phenol contents while peroxidase and lignin activity was Pb2+ dose dependent. The reduced leaves sizes of both seedlings were correlated with an increase in Pb2+ levels, and activities of peroxidase and lignin deposition in it. The intensification of activities of peroxidase and phenol in the Pb2+ treated plants were accompanied by an increase in the biosynthesis of the lignin contents as their function is of scavenging ROS radical. A strong correlation (r2=0.8570) was observed between Pb2+ and lignin deposition in the Lens culinaris whereas it was non-significant in Phaseolus mungo (r2=0.466). Increased in the lignin contents in the Lens culinaris as a chemical adaptation of the cell walls of various leaves tissues for endurance while decrease in the lignin contents in Phaseolus mungo at high dose of Pb2+may be attributed with the decline in the peroxidase activity. Investigations revealed that although plants adopt several biochemical strategies for their survival but toxicity of Pb2+was significant due to which plant fails to continue in stay alive.

Jamil S.,Jinnah University for Women | Siddiq A.,University of Karachi
Journal of Applied Pharmaceutical Science | Year: 2012

The purpose of the present study is to compare the extent of cardiovascular atherosclerotic risk associated with the lipid metabolism in women using hormonal contraceptives in urban population of low socio-economic group. Type of Study was cross sectional. Fifty-four young females of age ranging from 26-32 years maintained on Oral contraceptives (OC), Depo-medroxy progesterone (DMPA), Norethisterone (NET-EN), Implant and non hormonal intrauterine contraceptive device (IUCD) for at least one year were invited. Fasting blood samples were collected for the analysis of lipid parameters. Castelli indices I & II were also calculated to determine the CVD risk. All the results were entered in MS-Excel and mean ± standard deviation was calculated for each frequency. The result of Castelli indices showed that the use of OCs was associated with the highest atherogenic index followed by NET-EN, IUCD, DMPA and implant. The CVD risk may also be attributable to other life style factors as it was not drastically different among hormonal and non hormonal users. Though the risk in this group of young females maintained on contraceptives was found to be minimized because of good monitoring but continuation of hormonal methods might cause this slight predisposition to sub clinical CVD into a well defined atherosclerotic disease later in their lives. It is therefore recommended to use such methods under close monitoring and over the counter use of hormonal contraceptives should be discouraged.

Badar R.,Jinnah University for Women | Qureshi S.A.,University of Karachi
Journal of Applied Pharmaceutical Science | Year: 2012

The present study was designed to investigate the combine effectof Trichoderma hamatum and host-specific Rhizobium sp. of Vigna mungo on growth and biochemical parameters of same legume. The results proved that T.hamatum and host-specific Rhizobium sp are compatible with each other and their combine use was found effective not only in improving the growth parameters including lengths of roots & shoots and fresh biomass of experimental crop but also increasing the total chlorophyll, carbohydrate and crude protein contents as compared to control plants (p<0.05). Similarly, the amount of both nitrogen and phosphorus was significantly increased in leaves of the same legume (p<0.05). Therefore, T.hamatum could be a good alternate of chemical fertilizer and fungicide for improving the growth and productivity of V.mungo.

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