Jinnah Medical and Dental College

Karachi, Pakistan

Jinnah Medical and Dental College

Karachi, Pakistan

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Qadir F.,Liaquat National Medical College | Zehra T.,Liaquat National Medical College | Khan I.,Jinnah Medical and Dental College
Journal of the College of Physicians and Surgeons Pakistan | Year: 2011

Objective: To assess whether students find concept mapping a useful learning methodology to conceptualize and organize topics studied in CNS module of Pharmacology; and to evaluate whether addition of concept mapping assignment could help to improve examination scores. Study Design: An analytical study. Place and Duration of Study: College of Dentistry, Jinnah Medical and Dental College, Karachi, Pakistan, from March to May 2009. Methodology: A class of 50 BDS students was recruited for the study. Two randomly selected groups of 12 students each, prepared concept maps in topics from CNS pharmacology which were displayed and discussed during tutorial sessions. The other two groups (n=25) following the traditional teaching methodology, served as controls. Scores from best choice questions and short essay questions were compared between the investigational and control groups using the student's t-test with significance at p < 0.05. Feedback obtained after completion of the study was evaluated as percent response. Results: One-best-choice test of the control group showed a mean grade of 57.1 ± 16.7 vs. test group mean of 58.8 ± 13. For the short essay questions, control group obtained a mean of 52.3 ± 18.8 vs. test group mean grade of 53.8 ± 22.5. Both results were not significantly different (p > 0.05). However, feedback about concept mapping showed that the technique helped the students to conceptualize difficult topics in CNS pharmacology (86.36%). Concept mapping was particularly beneficial in preparing for exams as it provided a quick overview of the entire subject (68.68%). Conclusion: Students found concept mapping as a useful pedagogical tool which could potentially be used to acquire meaningful learning in Pharmacology as a supplement to traditional teaching techniques. It was not found beneficial in improving examination grades probably because standard examinations and concept mapping measure different cognitive domains. © 2011. College of Physicians & Surgeons Pakistan.


PubMed | Jinnah Medical and Dental College, University of Karachi, Dow University of Health Sciences and Liaquat National Hospital and Medical College
Type: Journal Article | Journal: JPMA. The Journal of the Pakistan Medical Association | Year: 2017

To determine the future priorities of young medical doctors in tertiary care hospitals in a major urban centre.This multi-centre cross-sectional study was conducted at four tertiary care hospitals of Karachi, Pakistan, from January to June 2015, and comprised medical interns. A questionnaire-based survey was conducted. The participants were inquired about their demographics, preferred places and hospitals for training in the future and reason for their choices. Differences in future choice for going abroad between gender, relationship status, household monthly income, etc. were analysed. SPSS 16 was used for data analysis.Of the 308 participants, 228(74%) were females and 80(26%) were males. The overall mean age was 24.561.18 years. Moreover, 118(38.3%) participants wanted to go abroad for their postgraduate training. Of them, 46(39%) wished to return to Pakistan after completing the training from abroad. Top five reasons for going abroad included better quality of training 60(50.8%), better environment and facilities 35(29.7%), security and safety 29(24.6%), better career growth 24(20.3%) and fianc/spouse settled there 18(15.3%). Preference of pursuing postgraduate training abroad outside Pakistan was significantly higher among doctors who were males (p=0.026), had graduated from medical colleges in Karachi (p=0.003), had household monthly income of greater than Rs100,000 (p<0.001) and had an immediate family member abroad (p<0.001). Besides, 190(61.7%) doctors wanted to pursue their training in Pakistan. Of them, 85(44.7%) wished to do their postgraduate training in public sector hospitals while 105(55.3%) had their preference for private hospitals. Main reasons for joining private hospitals included quality of training 40(38.1%), clean environment 25(23.8%), facilities 25(23.8%) and familiarity with environment 25(23.8%).Almost half of the female doctors were planning not to pursue their careers in the future, whereas half of the male doctors wished to go abroad for training with only one-third among them planning to return.


PubMed | Jinnah Medical and Dental College and The Indus Hospital
Type: Journal Article | Journal: JPMA. The Journal of the Pakistan Medical Association | Year: 2015

To determine the surgical outcome of patients with axial cervical spine fractures.The randomised double-blinded placebo-controlled clinical study was conducted at the Indus Hospital, Karachi, from August 2011 to August 2013. Patients were randomised to receive placebo or strontium ranelate postoperatively after surgical fixation of tibial diaphyseal fractures. Assessment of fracture healing was done clinically and radiologically at 30, 60 and 90 days. SPSS 21 was used for statistical analysis.Initially, 76 patients were enrolled, but 63(82.9%) completed the study. Out of 63 patients, 32(50.8%) were randomly assigned to group A and 31(49.2%) to group B, which was administered the placebo. Overall enhancement of fracture healing efficacy of strontium ranelate group was 20(62.5%) versus 9(29%) of the placebo group.Strontium ranelate was effective in enhancing fracture healing based on clinical and radiological assessment. Hence, it can be considered an effective therapeutic agent for accelerating fracture healing.


PubMed | Jinnah Medical and Dental College, Bahria University and Basic Medical science Institute
Type: Journal Article | Journal: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP | Year: 2016

To determine the expression of cyclin D1 and PTEN (phosphatase and tensin homolog) in endometrial hyperplasias and neoplasias.Analytical study.The study was conducted at BMSI, JPMC, Karachi, from January 2008 to December 2012.Analysis of endometrial samples, comprising of hysterectomies and curettage, was carried out. Immunohistochemical staining was done for PTEN and cyclin D1 expression.Fifty-three endometrial samples including 23 endometrial carcinomas, 6 complex hyperplasias with atypia, 14 complex hyperplasias without atypia, 6 simple hyperplasias without atypia and 4 normal proliferative endometrium were analyzed. Fifty-two percent (12 out of 23) and 48% (11 out of 23) cases of endometrial carcinomas showed complete loss of PTEN expression and cyclin D1 over expression, respectively. Five (5 out of 6) cases of complex hyperplasias with atypia and 64.28% (9 out of 14) cases of complex hyperplasia without atypia showed complete loss of or diminished expression of PTEN whereas 66.66% (4 out of 6) cases of endometrial hyperplasia with atypia and 50% (7 out of 14) cases of endometrial hyperplasia without atypia showed cyclin D1 overexpression (p < 0.001).Loss of PTEN, expression and cyclin D1 overexpression was seen in a significant number of well differentiated endometrial adenocarcinomas and complex hyperplasias with atypia, suggesting both as an early event in endometrial carcinogenesis.


Ali N.H.,University of Karachi | Ali N.H.,Jinnah Medical and Dental College | Farooqui A.,University of Karachi | Khan A.,University of Karachi | And 2 more authors.
Journal of Infection in Developing Countries | Year: 2010

Background: This study was conducted to examine the frequency of contamination in retail meat available in Karachi, Pakistan. Methodology: Raw meat samples (250) and surface swabs (90) from meat processing equipment and the surrounding environment were analyzed for microbiological contamination. Results: Out of 340 samples, 84% were found to be contaminated with bacterial species, including Klebsiella, Enterobacter, Staphylococcus aureus and Bacillus subtilis. A total of 550 (66%) of the bacterial isolates were potential pathogens. Of these, 342 and 208 isolates were from meat and environmental samples respectively. Food-borne pathogens isolated from meat samples included Escherichia coli O157:H7, Listeria, Salmonella Enteritidis and Shigella species whereas environmental samples yielded Staphylococcus aureus and Shigella species. Four strains of Brucella species were also isolated from meat samples. Total aerobic counts ranged between 108 -1010 CFU/g or cm2. Resistance to a wide range of antibiotics was observed. Resistance rates to ampicillin, amoxicillin, novobiocin and cefaclor were from 62 to 75% in general. Thirty-three percent of Salmonella isolates were resistant to ampicillin. No quinolone resistance was observed. Biofilm formation was observed among 88 (16%) pathogenic bacteria including E. coli, Klebsiella, Enterobacter species and Staphylococcus aureus. Conclusions: Food-borne pathogens found in retail shops could be sources for horizontal contamination of meat. Our data confirm the circulation of antibiotic resistant and biofilm forming pathogens in raw meat and its environment in retail shops in Pakistan, which could play a role in the spread of antimicrobial resistance amongst food-borne bacteria. © 2010 Hassan Ali et al.


Ali N.H.,Jinnah Medical and Dental College | Ali N.H.,University of Karachi | Faizi S.,University of Karachi | Kazmi S.U.,University of Karachi
Pharmaceutical Biology | Year: 2011

Context: Development of resistance in human pathogens against conventional antibiotic necessitates searching indigenous medicinal plants having antibacterial property. Twenty-seven medicinal plants used actively in folklore, ayurvedic and traditional system of medicine were selected for the evaluation of their antimicrobial activity for this study. Eleven plants chosen from these 27 are used as spices in local cuisine. Objective: Evaluation of the effectiveness of some medicinal plant extracts against clinical isolates. Material and methods: Nonedible plant parts were extracted with methanol and evaporated in vacuo to obtain residue. Powdered edible parts were boiled three times and cooled in sterile distilled water for 2 min each and filtrate collected. The minimum inhibitory concentration (MIC) of plant extracts and filtrates/antibiotics was evaluated against clinical isolates by microbroth dilution method. Results: Water extract of Syzygium aromaticum L. (Myrtaceae) buds, methanol extracts of Ficus carica L. (Moraceae) and Olea europaea L. (Oleaceae) leaves and Peganum harmala L. (Nitrariaceae) seeds had MIC ranges of 31.25-250 μg/ml. S. aromaticum inhibited growth of Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Salmonella enterica serovar Typhi and Pseudomonas aeruginosa. F. carica and O. europaea inhibited growth of S. aureus, S. epidermidis, and S. pyogenes whereas P. harmala was effective against S. aureus, Acinetobacter calcoaceticus and Candida albicans. Ampicillin, velosef, sulfamethoxazole, tetracycline and ceftazidime, cefotaxime, cefepime, which are used as control, had MIC ≥50 and 1.5 μg/ml, respectively, for organisms sensitive to extracts. Discussion and conclusion: Mono/multiextract from identified plants will provide an array of safe antimicrobial agents to control infections by drug-resistant bacteria. © 2011 Informa Healthcare USA, Inc.


Junaid M.,Jinnah Medical and Dental College | Ahmed S.Q.,Aga Khan University | Kazi M.,Aga Khan University | Ali N.S.,Aga Khan University
BMJ Case Reports | Year: 2015

Pilonidal sinus is very commonly associated with the sacrococcygeal area, but its presence within the head and neck is still unknown to many. Once diagnosed, it is easy to treat and should, therefore, be kept in mind as a possibility when coming across a discharging sinus swelling. We share our experience of two cases of pilonidal sinus presenting over the nasal bridge and their management. Copyright 2015 BMJ Publishing Group. All rights reserved.


Rathi M.K.,Jinnah Medical and Dental College | Fida M.,Aga Khan University
Journal of the College of Physicians and Surgeons Pakistan | Year: 2014

Objective: To investigate the applicability of Pont's index in estimating the maxillary arch width depending on the sum of mesiodistal dimensions of maxillary incisors. Study Design: Cross-sectional, comparative study. Place and Duration of Study: Dental Clinics, The Aga Khan University Hospital, Karachi, from January 2006 to December 2008. Methodology: A total of 150 subjects were included. All measurements were taken on maxillary study casts by a digital caliper. The premolar arch width was taken from the first premolar of the left side to the right side at the distal end of its occlusal groove. The molar arch width was taken from the maxillary left permanent molar to the same of the right at its mesial pit on the occlusal surface. The combined width of the maxillary incisors was taken at their greatest mesiodistal widths. The predicted arch widths were estimated with the Pont's formula: Premolar width (P) =(Sum of Incisor widths/80) × 100, Molar width (M) =(Sum of Incisor widths/64) × 100 Incisor diameters and arch widths were described in terms of mean values, standard deviations, and coefficients of variation. Correlation coefficients were computed between observed arch widths and those predicted according to Pont's M and P indices. Results: The mean age was 15.8 ± 1.6 years. Low correlations existed between observed and Pont's predicted arch widths in both premolar (r = 0.364) and molar (r = 0.238) regions. Twenty two percent of interpremolar arch widths and 18% of intermolar arch widths showed differences between -1 mm to 1 mm. Conclusion: Low correlations were found between observed and Pont's predicted arch widths. Pont's index is unlikely to be clinically useful as a true predictor of arch width.


Lakhani M.J.,Jinnah Medical and Dental College
Journal of Ayub Medical College, Abbottabad : JAMC | Year: 2011

Impaction of the 3rd molar is a high incident problem occurring in up to 73% of young adults in Europe. Appropriate follow-up routines and optimal timing for surgical removal of the 3rd molars can be established in patients judged to be at increased risk of impaction. The purpose of this study was to identify risk factors for mandibular 3rd molar impaction in adolescent orthodontic patients and to establish anterior arch crowding as a predictive model for mandibular 3rd molar impaction. Pre-treatment Orthopantomogram (OPG) of 158 orthodontic patients with the evidence of anterior arch crowding on pre-treatment study models were evaluated for mandibular third molar position. Out of 158 patients, 45 were male and 113 were female. Ninety-seven (61%) of the patients showed anterior arch crowding with a space discrepancy of 5-10 mm calculated on the pretreatment study models. Fifty-seven patients showed 107 third molar impactions. Anterior arch crowding in these patients was ranging from 7-10 mm. Out of 107 impacted third molars 73 were Mesioangular 14 were Distoangular 6 were Vertical and 14 were Horizontal. If the arch size is smaller as compared to the tooth size the evidence of lack of space would be there in anterior segment as crowding and in posterior segment as 3rd molar impaction.


Mahesh A.,Jinnah Medical and Dental College | Tirmizi S.Z.A.,Jinnah Medical and Dental College | Sanwer Ali S.,Jinnah Medical and Dental College
Medical Channel | Year: 2011

Objective: To determine the frequency & associated factors of premenstrual syndrome in medical collage students. Methods: A cross sectional study by random sampling was conducted during July to September 2009 among the 200 medical students aged b/w 18-25 years of private medical institution. Questionnaire was derived from DMS-IVdiagnostic criteria for premenstrual dysphonic disease and PMS symptoms. Results: All of the students (100%) who participated in this study reported some degree of at least one symptom. Using DSM-IV diagnostic criteria prevalence of PMS was found to be 59%. The order of frequency of psychological symptoms include increase appetite 67.5%, worry and anxiety 60%, tired or lethargic 54%, felt suddenly sad / tearful 56.5%, interpersonal conflict 54% and depressed mood 52.5% and physical symptoms were found in the order of backache 55%, acne 50.5%, joint or muscle pains 49.5%, abdominal bloating 44.5% and weight gain 40.5%. Age (p =.460), Living condition (p=0.270) and residence (p=0.170) showed no association with the severity of symptoms of PMS. Conclusion: PMS is frequently occurring problem in medical students affecting the mental well being and concentration of students on their academics. It requires urgent identification and attention for better academic achievements.

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