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Jinjiang, China

Cai R.-W.,Fujian Medical University | Chen Y.-F.,Fujian Medical University | Huang Y.-H.,Jinjiang City Hospital | Lin Y.-Y.,Jinjiang City Hospital | And 5 more authors.
Journal of Shanghai Jiaotong University (Medical Science) | Year: 2014

Objective: To explore the effects of hypertension on the treatment of patients with acute ischemic stroke by recombinant tissue plasminogen activator (rt-PA) intravenous thrombolysis. Methods: Patients with acute ischemic stroke who were administrated intravenous rt-PA within 4.5 h after the onset were selected. The onset time was between February 2009 and June 2013. Modified Rankin Scale (mRS) was used to evaluate the recovery of neurological functions. Patients were divided into the good prognosis group (mRS scores were 0-1) and poor prognosis group (mRS scores were 2-6) according to the scores of mRS. General informations of patients were collected and compared between two group and risk factors were analyzed. Results: The difference of the percentage of patients with hypertension of the good prognosis group (n=92) and poor prognosis group (n=83) was not statistically significant (66.30% vs 67.47%,P=0.870). The results of logistic multivariate regression analysis showed that hypertension was neither a risk factor of symptomatic intracranial hemorrhage (OR=0.453, 95%CI: 0.087-2.352, P=0.346) nor a influencing factor of the prognosis of thrombolysis (OR=1.014, 95%CI: 0.933-1.101, P=0.746). Conclusion: The hypertension has no significant effect on the treatment of patients with acute ischemic stroke by rt-PA intravenous thrombolysis. ©, 2014, Editorial Department of Journal of Shanghai Second Medical University. All right reserved. Source


Chen Y.-F.,Fujian Medical University | Huang Y.-H.,Jinjiang City Hospital | Cai R.-W.,Fujian Medical University | Lin Y.-Y.,Jinjiang City Hospital | And 4 more authors.
Journal of Shanghai Jiaotong University (Medical Science) | Year: 2015

Objective: To explore the relationship between serum homocysteine (Hcy) and leukoaraiosis (LA). Methods: Patients with LA who were admitted and treated from May 2013 to May 2014 were selected as subjects and divided into LA group (n=164) and non-LA group (n=104) according to the incidence of LA. Clinical data of two groups (gender, age, hypertension, diabetes, smoking, alcohol consumption, blood lipid, plasma fibrinogen, fasting blood glucose, D-dimer, uric acid, albumin, and Hcy) were collected. Univariate analysis and multivariate logistic regression analysis were used to analyze risk factors relevant to LA. Results: Hcy levels of LA group [(15.57±6.22) μmol/L] were higher than those of non-LA group [(12.74±4.93) μmol/L] and the difference between two groups was statistically significant (P<0.001). The multivariate Logistic regression analysis showed that Hcy (P=0.041; OR: 1.118; 95%CI: 1.004-1.245) was independently correlated with the incidence of LA. Conclusion: Hcy is an independent risk factor of leukoaraiosis. ©, 2015, Editorial Department of Journal of Shanghai Second Medical University. All right reserved. Source

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