Jining Medical University

Jining, China
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Ying K.,Jining Medical University
Journal of Chemical and Pharmaceutical Research | Year: 2014

With nonlinearity, large lag and time-varying model parameters of cement rotary kiln, this paper proposed a burning zone temperature control system of cement rotary kiln based on CMAC neural network. By Dynamic adjustment of PID controller parameters with CMAC neural network, combined with rotary kiln temperature control mechanism, the temperature controller based on CMAC-PID was designed. Then the good dynamic and static characteristics and anti-interference ability of system were verified by simulation test. Finally hardware and software design of temperature control system were completed. In order to improve the rapidity of PID parameters online adjustment, OB35 program block in PLC was used to real-time adjustment of CMAC parameters. This control system has been applied to QuFu cement rotary kiln project, realizing none overshoot and high control precision of the burning zone temperature.

Li J.,Jining Medical University
Journal of Modern Optics | Year: 2017

To overcome the shortcomings of a non-uniform description of relative position and attitude using traditional methods, this paper proposes an algorithm for binocular vision measurement of a leader–follower rigid body’s relative position and attitude based on dual-quaternion. Feature lines on the leader rigid body are selected as reference lines. Then, the coordinate values of the feature lines are obtained in the system of proprio-coordinates of the follower rigid body based on the binocular vision measurement principle, with the feature lines represented by Plücker lines. The relationship of relative position and attitude between the leader rigid body and the follower rigid body is illustrated by optimizing the feature that enables the dual-quaternion to transform the feature lines. A singular value decomposition approach is used to determine the relative position and attitude between the two rigid bodies. The simulation results show that this method overcomes the deficiencies associated with the separate measurement of position and attitude using a traditional algorithm. This method exhibits the ability to handle noise and satisfies the accuracy requirements for a general rigid body. © 2017 Informa UK Limited, trading as Taylor & Francis Group

Shi C.,Shandong Jining No1 Peoples Hospital | Xu X.,Jining Medical University
Biomedicine and Pharmacotherapy | Year: 2013

MicroRNAs (miRNAs) are a new class of short noncoding RNAs with post-transcriptional regulation and participate in diverse physiological and pathological processes. MiR-22, ubiquitously expressed in various tissues, plays a functional important role in life processes and is recently proved to involve in many cancers. In present study, we had shown that miR-22 was down-regulated much more obviously in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) cell lines as well as in clinical tissues. Cyclin-dependent kinase inhibitor 1A (CDKN1A) was found to be inversely correlated with miR-22 and was identified as a target of miR-22. Overexpression of miR-22 in vitro effectively suppressed CDKN1A expression and inhibited cell proliferation. We conclude that miR-29c may play an important role as a tumor suppressive microRNA in the development and progression of HBV-related HCC by targeting CDKN1A. © 2013 Elsevier Masson SAS.

Bortezomib, a proteasome inhibitor, has been therapeutic effects in some solid tumors. In the present work, the effects of bortezomib on laryngeal squamous cell carcinoma Hep-2 cell line was investigated and the role of redox equilibrium was explored. The results showed that bortezomib decreased the cell viability and increased the apoptosis in Hep-2 cells. In addition, bortezomib overproduced reactive oxygen species (ROS) and induced the loss of mitochondrial membrane potential (ΔΨm). And the activity of caspase-3 increased. N-acetyl-L-cysteine (L-NAC), a ROS scavenger, alleviated oxidative stress and inhibited the apoptosis induced by bortezomib. However, buthionine sulfoximine (BSO), an inhibitor of GSH synthetase, aggravated bortezomib-induced oxidative stress and apoptosis. So bortezomi-induced the apoptosis of Hep-2 cells via disrupting redox equilibrium. © 2012 Elsevier Masson SAS.

Sun H.,Jining First Peoples Hospital | Yu T.,Jining Medical University | Li J.,Shanghai Skin Diseases Hospital
Cancer Letters | Year: 2011

Here we report an oral alkylphospholipid perifosine dramatically sensitizes chemo-resistant ovarian cancer cells to paclitaxel induced cell death and apoptosis in vitro. We found that co-administration perifosine with paclitaxel in human ovarian cancer cells led to the inhibition of AKT/mTOR complex 1 (mTORC1), a marked increase in ceramide and reactive oxygen species (ROS) production, and a striking increase in the activation of pro-apoptosis pathways, including caspase 3, c-Jun N-terminal kinases (JNK) and AMP-activated protein kinase (AMPK). These signaling events together caused a marked increase of cancer cell apoptosis. Combining paclitaxel with perifosine may represent a novel anti-ovarian cancer strategy. © 2011 Elsevier Ireland Ltd.

Qiu C.,Karolinska Institutet | Qiu C.,Jining Medical University
Journal of Alzheimer's Disease | Year: 2012

Alzheimer's disease (AD) is a major cause of functional dependence, poor quality of life, institutionalization, and mortality among elderly people. As a multifactorial disorder, AD has been frequently linked to vascular risk factors (e.g., smoking, hypertension, obesity, diabetes, hyperlipidemia, and inflammation) in numerous prospective cohort studies of the general population. Systematic reviews and meta-analyses of prospective studies have from the life-course perspective revealed an age-dependent association with the risk of AD for several vascular risk factors such as high blood pressure, obesity, and high total cholesterol, such that possessing these factors in mid-life, but not necessarily in late-life, is associated with an increased risk of AD. The biological plausibility for vascular risk factors to be involved in the pathogenesis and clinical manifestation of Alzheimer syndrome is partly supported by population-based neuroimaging and neuropathological studies. However, randomized controlled trials that target those major cardiovascular risk factors (e.g., antihypertensive, cholesterol-lowering, and anti-inflammatory therapies) have generally failed to prove as efficacious preventative approaches for AD. To bridge the gap, the multifactorial nature of AD and the proper time-window for intervention should be taken into account in the future when designing preventative interventions against this devastating disorder. © 2012 - IOS Press and the authors. All rights reserved.

Yang J.,Jining Medical University | Wang X.,Heze University | Shi H.,Qingdao University of Science and Technology
Sensors and Actuators, B: Chemical | Year: 2012

A highly sensitive method for detection of DNA hybridization and phosphinothricin acetyltransferase (PAT) gene fragment, one of the screening detection genes of the transgenic plants, was developed based on the glassy carbon electrode (GCE) modified with polyaniline-(mesoporous nanozirconia)/poly-tyrosine film. The film exhibited excellent properties for immobilizing DNA probes (ss-DNA) and sensing DNA hybridization. The fabrication processes of the film, the DNA immobilization and hybridization on the film were studied by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), and found that the electron transfer resistance (Ret) of the electrode surface increased with the concentration of the target DNA hybridized with the DNA probes, which could be applied for determination of the DNA hybridization and PAT gene. The dynamic detection range was from 1.0 × 10 -13 mol L -1 to 1.0 × 10 -6 mol L -1, and the detection limit was 2.68 × 10 -14 mol L -1. Compared with the other electrochemical DNA biosensors based on zirconia-based materials, the proposed biosensor showed its own performance of simplicity, good stability, fine selectivity and high sensitivity. © 2011 Elsevier B.V. All rights reserved.

Gao H.,Jining Medical University | Liu C.,Jining Medical University
Biomedicine and Pharmacotherapy | Year: 2014

MicroRNAs are a class of endogenous non-coding RNAs that regulate gene expression at post-transcriptional level, thus participating in diverse biological pathways. Increasing miRNAs are found to dysregulate hepatocellular carcinoma (HCC) and are involved in liver tumorigenesis. In this study, miR-429 was found to obviously downregulate much more in hepatitis B virus (HBV)-related hepatocellular carcinoma. To evaluate the effects of miR-429, miR-429 was over-expressed in HepG2.2.15 cells. The results have proved that overexpression of miR-429 decreased cell proliferation and induced cell apoptosis. Further, overexpression of miR-429 can suppress the secretion of HBsAg and HBeAg. In concordance to this, the level of NOTCH1 expression was high in human HBV-related HCC tissues and HepG2.2.15 cells. MiR-429 directly targeted NOTCH1 and reduced both mRNA and protein levels of NOTCH1 which stimulated proliferation and suppressed apoptosis in HCC cells. Our results provide new insight into the function of miR-429 in HBV-related HCC. It is beneficial to insight into the mechanism of HBV infection and pathophysiology of HBV-related HCC. © 2014 Elsevier Masson SAS.

The majority of metastatic melanomas are resistant to different chemotherapeutic agents, consequently, the search for novel anti-melanoma agents and adjuvant is urgent. Here, we found that 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), an inhibitor of glycosphingolipid biosynthesis, enhanced curcumin-induced cell growth inhibition and apoptosis in two melanoma cell lines (WM-115 and B16). PDMP facilitated curcumin-induced ceramide accumulation; the latter contributed to melanoma cell apoptosis. PDMP also dramatically enhanced curcumin-induced c-Jun N-terminal kinase activation, which was important to melanoma cell apoptosis. Meanwhile, curcumin plus PDMP treatment largely inhibited the activation of pro-survival PI3K/AKT signal pathway. In conclusion, PDMP-sensitized curcumin-induced melanoma cell growth inhibition and apoptosis in vitro due to changes of multiple signal events. Combining PDMP with curcumin may represent a new therapeutic intervention against melanoma.

Liu C.,Jining Medical University
Archives of Pharmacal Research | Year: 2013

The cancers are a series of serious diseases in the world, and the mechanism involved in many cancers has not yet been fully elucidated. Therefore, it is a very major and significant to explore the molecular mechanisms of cancer occurence and development. MicroRNAs (miRNAs), a class of molecules that regulates gene at post-transcription expression, play an important role in tumorigenesis. It has been proved that a number of miRNAs identified as aberrantly expressed during cancer development. In addition, some of the miRNAs may have prognostic significance. It is the aim of this review to describe the important role of miRNAs in cancer initiation and development as predictive, diagnostic, prognostic biomarkers and novel therapeutic strategies. © 2013 The Pharmaceutical Society of Korea.

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