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Jining, China

Zhang A.,Jining Medical College Affiliated Hospital | Wang H.,Jining Medical College | Qin X.,Jining Medical College Affiliated Hospital | Pang S.,Jining Medical College Affiliated Hospital | Yan B.,Jining Medical College Affiliated Hospital
Biochemical and Biophysical Research Communications

Parkinson's disease (PD) is one of the most common neurodegenerative diseases. To date, genetic causes and underlying molecular mechanisms for sporadic PD remain largely unknown. Sirtuis are highly conserved NAD-dependent class III deacetylases. SIRT1, the closest to yeast Sir2, has deacetylase activity and ADP-ribosyltransferase activity. SIRT1 gene has been connected to many cellular processes and implicated in human diseases, such as obesity, type 2 diabetes, cancer and neurodegenerative diseases. Studies in animal model have also associated SIRT1 with aggregation of alpha-synuclein, a critical protein in the PD pathogenesis. We hypothesized that the genetic variants within the regulatory regions of SIRT1 gene that repress its gene expression, rather than mutations in its coding region that abolish SIRT1 function, may contribute to PD as a risk factor. In this study, we genetically analyzed the promoter region of SIRT1 gene in sporadic PD patients and ethic-matched healthy controls. Three novel heterozygous sequence variants, g.69644133C>G, g.69644213G>A and g.69644351G>A, were identified in PD patients, but in none of controls, which may alter the transcriptional activities of SIRT1 gene promoter, resulting in reduced SIRT1 levels. One novel heterozygous variant, g.69644219G>A, linked with single-nucleotide polymorphism - g.69644217A>C (rs932658), was only found in one control, which may have no functional activity. Therefore, our results suggested that genetic variants within the SIRT1 gene promoter may repress SIRT1 gene expression, contributing to PD as a risk factor. © 2012 Elsevier Inc.. Source

Li S.,Shandong University | Xu H.,Shandong University | Li S.-C.,Jining Medical College | Qi X.-Q.,Shandong University | Sun W.-J.,Shandong University
Tumor Biology

The role of vitamin D receptor (VDR) rs2228570 polymorphism on the risk of ovarian cancer has been studied in many studies, but the relationship between VDR rs2228570 polymorphism and ovarian cancer is still unclear. We thus performed a meta-analysis of published studies to provide a comprehensive assessment of the association. Fourteen individual studies with a total of 10,964 subjects were finally included into the meta-analysis. We assessed the association by calculating the pooled odds ratio (OR) with 95% confidence intervals (95% CI). There was no heterogeneity among those included studies. Meta-analysis of 14 studies showed that the VDR rs2228570 polymorphism was associated with risk of ovarian cancer under three main comparison models (T versus C: OR=1.09, 95% CI 1.03 to 1.15, P=0.004; TT versus CC: OR=1.17, 95% CI 1.04 to 1.32, P=0.01; and TT/CT versus CC: OR=1.12, 95% CI 1.03 to 1.21, P=0.007). Subgroup analysis in Caucasians further identified the obvious association. There was no evidence of publications bias. These data from the meta-analysis suggest that VDR rs2228570 polymorphism is associated with risk of ovarian cancer in Caucasians. More studies are warranted to assess the association between the VDR rs2228570 polymorphism and ovarian cancer in Asians and Africans. © International Society of Oncology and BioMarkers (ISOBM) 2013. Source

Liu Z.-Q.,Jining Medical College | Xing S.-S.,Shandong University of Traditional Chinese Medicine | Zhang W.,Shandong University
Journal of Spinal Cord Medicine

Background: Ischemic/reperfusion (I/R) injury of the spinal cord is a serious complication that can result from thoracoabdominal aortic surgery. Objective: To investigate the neuroprotective effect of curcumin against I/R injury in a rabbit model. Methods: A total of 36 rabbits were randomly divided into three groups: sham, I/R, and curcumin-treated group. Rabbits were subject to 30-min aortic occlusion to induce transient spinal cord ischemia. Neurological function was observed after reperfusion and spinal cord segment (L3-L5) was collected for histopathological evaluation. Malondialdehyde (MDA) and total superoxide dismutase (SOD) activity were also assayed. Results: Rabbits in I/R group were induced to paraplegia. While after 48-hour treatment, compared with I/R group, curcumin significantly improved neurological function, reduced cell apoptosis and MDA levels as well as increased SOD activity (P < 0.05). Conclusions: The results suggest that curcumin, at least in an animal model, can attenuate transient spinal cord ischemic injury potentially via reducing oxidative damage, which may provide a novel approach in the treatment of spinal cord ischemic injury. © The Academy of Spinal Cord Injury Professionals, Inc. 2013. Source

Liu H.,Sichuan University | Chen R.,Sichuan University | Chen R.,Jining Medical College | Chen X.,Sichuan University
Organic and Biomolecular Chemistry

A flexible and practical protocol for the asymmetric synthesis of renieramycin-type antitumor alkaloids is described, in which the stereoselective Pictet-Spengler cyclization of amino ester 16 and aldehyde 15 by regulating temperature and the automatic lactamization after N-deprotection of the cyclization product are exploited to rapidly construct the common pentacyclic framework. (-)-Renieramycin G and (-)-jorunnamycin A, as representative members of the two subgroup renieramycin-type alkaloids, are obtained in 19 steps from l-tyrosine with 15.8% and 14.3% overall yield respectively. This journal is © The Royal Society of Chemistry 2014. Source

Xi B.,Shandong University | Liang Y.,Jining Medical College | He T.,Guangdong Medical College | Reilly K.H.,Tulane University | And 4 more authors.
Obesity Reviews

The objective of this study is to examine the trends in body mass index (BMI), waist circumference (WC) and prevalence of overweight (BMI 25-27.49kg m -2), general obesity (BMI≥27.5kg m -2) and abdominal obesity (WC≥90cm for men and ≥80cm for women) among Chinese adults from 1993 to 2009. Data were obtained from the China Health and Nutrition Survey, which was conducted from 1993 to 2009 and included a total of 52,621 Chinese adults. During the period of 1993-2009, mean BMI values increased by 1.6kg m -2 among men and 0.8kg m -2 among women; mean WC values increased by 7.0cm among men and 4.7cm among women. The prevalence of overweight increased from 8.0 to 17.1% among men (P<0.001) and from 10.7 to 14.4% among women (P<0.001); the prevalence of general obesity increased from 2.9 to 11.4% among men (P<0.001) and from 5.0 to 10.1% among women (P<0.001); the prevalence of abdominal obesity increased from 8.5 to 27.8% among men (P<0.001) and from 27.8 to 45.9% among women (P<0.001). Similar significant trends were observed in nearly all age groups and regions for both men and women. The prevalence of overweight, general obesity and abdominal obesity among Chinese adults has increased greatly during the past 17 years. © 2011 The Authors. obesity reviews © 2011 International Association for the Study of Obesity. Source

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