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Jingjiang, China

Li S.,Luzhou Medical College | Qi X.,Tongji University | Huang Y.,Jingjiang Peoples Hospital | Liu D.,Tongji University | And 2 more authors.
Clinical Lung Cancer | Year: 2015

The success in identifying the chromosomal rearrangements involving the anaplastic lymphoma kinase (ALK) as an oncogenic driver has thoroughly changed the treatment of non-small-cell lung cancer. In the past decade, targeted drugs have emerged as an efficient personalized strategy for ALK-rearranged non-small-cell lung cancer. The accelerated approval of potent ALK inhibitors, such as crizotinib and more recently ceritinib (LDK378), based on the well designed phase I/II trials has been a landmark success in clinical cancer research and contributes a new era of oncogenic targeted therapy characterized by elegant clinical trial design. In this review, we aim to present the current knowledge on acquired resistance of crizotinib known as a first-in-class ALK inhibitor and potential solutions to improve the cost-effectiveness, and to review the difference between ceritinib and crizotinib; preclinical data and results of the elegant early clinical trial of ceritinib which promoted its accelerated approval, pharmacokinetics, safety profile, and tolerability, the updated results (eg, efficacy on brain metastases), and robust design of ongoing phase II/III trials, and future directions of ceritinib to be a potent alternative to crizotinib for ALK-rearranged non-small-cell lung cancer are also presented. © 2015 Elsevier Inc. Source


Bao H.-W.,Jingjiang Peoples Hospital | Wang Q.,Nanjing Medical University
National Medical Journal of China | Year: 2010

Objective: To explore the efficacy of shoulder arthroplasty for comminuted proximal humeral fracture and measure anatomical specimens to determine the proximal humeral data for placing a shoulder prosthesis and designing a new prothesis. Methods: A total of 68 Chinese adult cadaveric humeri were selected. The parameters of humeral breadth of proximal epiphysis, across diameter of humeral head, vertical diameter of humeral head, retroverion angle, maximal interval of humeral head-tuberosity and humeral head-shaft angle were measured and analyzed with SPSS 10 program. Results: The data were as follows: Across diameter of humeral head: left (40.7 ± 1.9) mm, right (40.5 ± 1.4) mm; Vertical diameter of humeral head: left (44.5 ± 1.3) mm, right (43.4 ± 1.5) mm; Retroversion angle: left (26.6 ± 1.4)°, right (26.8 ± 1.6)°; Max interval of humeral head-tuberosity: left (6.6 ± 1.1) mm, right (6.8 ± 1.0) mm; Head-shaft angle: left (134.3 ± 3.5)°, right (135.6 ± 1.5)°; Superior breadth: left (47.2 ± 1.3) mm, right (46.9 ± 1.5) mm. Conclusion: Ideally the fitting prosthesis' diameter is 40-45 mm with a retroversion angle of approximately 30°. And the prosthesis should be higher than the greater tubercle by 6-8 mm. Copyright © 2010 by the Chinese Medical Association. Source


Li J.,Sun Yat Sen University | Shen Y.,Sun Yat Sen University | Tan L.,Sun Yat Sen University | Feng M.,Sun Yat Sen University | And 4 more authors.
Journal of Thoracic Disease | Year: 2014

Objective: To explore the safety and efficacy of modified cervical triangulating stapled anastomosis (TSA) for gastroesophageal anastomosis (GEA) in minimally invasive esophagectomy (MIE). Methods: From January 2013 to November 2013, eighty-four patients who underwent three-stage MIE was enrolled. During the cervical stage, either circular stapled (CS) or triangulating stapled (TS) anastomosis was applied for GEA. Clinical features were collected and compared to identify the differences between the two groups. Results: A total of 84 patients were included in this study. The clinical characteristics were close between the two groups. Intra-operatively, the duration of GEA was close between the two groups (18±3.4 vs. 17±2.7 min, P=0.139). Post-operatively, Cervical anastomotic leakage occurred in one (3.0%) of the 33 TS patients, but in six (11.8%) of the 51 CS patients (P=0.312). The incidence of anastomotic stenosis was 0.0% and 13.7% in the TS and CS groups, respectively (P=0.069). The overall incidence of postoperative complications was significantly lower in TS than that in CS (15.2% vs. 35.3%, P=0.043). There was no difference in the median length of hospital stay or perioperative mortality rate between the two groups. Conclusions: TSA is a safe and effective alternative for GEA, which would probably lower the incidence of leakage and stenosis following MIE. Further studies based on larger volumes are required to confirm these findings. © Pioneer Bioscience Publishing Company. Source


Ma J.,Fudan University | Jiang R.,Fudan University | Fan L.,Jingjiang Peoples Hospital | Mei X.,Fudan University | And 5 more authors.
Oncotarget | Year: 2015

Purpose: To evaluate the recurrence patterns in a series of patients who presented with isolated locoregional recurrences (ILRRs) after mastectomy and adjuvant systemic therapies in the contemporary era. Methods: A total of 235 patients who developed ILRRs between 2005 and 2013 were classified into subgroups based on nodal status, hormone receptor status, and biologic subtype. The annual frequency of recurrences, association between biologic subtype and interval to recurrence (ITR), and anatomical distribution were evaluated. Results: For the entire group, recurrence peaked within the first 3 years after mastectomy, and then decreased significantly with time. Node-positive patients were observed to recur early, and a greater proportion recurred within 5 years (86.7% vs. 72.8%, X2 = 6.83, P = 0.008) than did node-negative subgroup. Overall, the median ITR was 33.2 (range, 4.5 - 236) months. Biologic subtype specific median ITR were 43.3 (7.9 - 236.0) months for luminal A, 42.2 (6.1 - 143.3) months for luminal B, 23.8 (6.9 - 47.3) months for luminal HER2, 18.2 (6.6 - 117.5) months for HER2, and 21.8 (4.5 - 138.2) months for TNBC, and their difference was statistically significant (X2 = 7.4, P = 0.001). Among all ILRRs, 51.5% (n = 121) were isolated to regional nodes. Conclusions: We demonstrates that the time course is consistent with previous description, biologic subtype is associated with ITR, and regional nodes is the most common place for recurrences in this series of patients who developed ILRRs following mastectomy and contemporary adjuvant systemic therapies but without PMRT. Source


Bao H.W.,Jingjiang Peoples Hospital
Zhonghua yi xue za zhi | Year: 2010

To explore the efficacy of shoulder arthroplasty for comminuted proximal humeral fracture and measure anatomical specimens to determine the proximal humeral data for placing a shoulder prosthesis and designing a new prothesis. A total of 68 Chinese adult cadaveric humeri were selected. The parameters of humeral breadth of proximal epiphysis, across diameter of humeral head, vertical diameter of humeral head, retroverion angle, maximal interval of humeral head-tuberosity and humeral head-shaft angle were measured and analyzed with SPSS 10 program. The data were as follows: Across diameter of humeral head: left (40.7 ± 1.9) mm, right (40.5 ± 1.4) mm; Vertical diameter of humeral head: left (44.5 ± 1.3) mm, right (43.4 ± 1.5) mm; Retroversion angle: left (26.6 ± 1.4)°, right (26.8 ± 1.6)°; Max interval of humeral head-tuberosity: left (6.6 ± 1.1) mm, right (6.8 ± 1.0) mm; Head-shaft angle: left (134.3 ± 3.5)°, right (135.6 ± 1.5)°; Superior breadth: left (47.2 ± 1.3) mm, right (46.9 ± 1.5) mm. Ideally the fitting prosthesis' diameter is 40 - 45 mm with a retroversion angle of approximately 30°. And the prosthesis should be higher than the greater tubercle by 6-8 mm. Source

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