Jinan Nursing Vocational College
Jinan Nursing Vocational College
Yang J.,Yantai Blood Center |
Li J.-X.,Yantaishan Hospital |
Song Z.,Yantai Blood Center |
Xia X.-Y.,Jinan Nursing Vocational College
Bangladesh Journal of Pharmacology | Year: 2015
Allergic transfusion reaction is an anomaly that develops within several hours of transfusion which is usually treated by antihistamine. In the present study, we are looking into daucosterol, an extract of Traditional Chinese Medicine (TCM) Cordyceps, as a potential inhibitor of histidine decarboxylase. The approach of molecular docking and Molecular Dynamics Simulation (MDS) on a traditional anti-inflammatory Chinese medicine gave an atomic insight of the inhibition. The daucosterol was binding with a ΔG of-3.17 Kcal/mol, to inhibit histamine synthesis by binding to histidine decarboxylase, possibly via the flexible catalytic loop. Such inhibitors that were designed to block the flexibility of the catalytic loop are potential candidates for further drug development program. © 2015, Bangladesh Pharmacological Society. All rights reserved.
Zhu X.,Shandong University |
Gao R.,Shandong University |
Gao R.,Jinan Nursing Vocational College |
Liu Z.,Shandong University |
And 5 more authors.
European Journal of Neuroscience | Year: 2016
Depression is a major neuropsychiatric disorder that exerts deleterious effects upon public health. However, the neuronal mechanisms of depression remain largely uncharacterized, which has retarded the identification and development of effective therapeutic tools for the treatment of this disorder. The aim of this study was to explore the neuronal mechanisms underlying the protective effects of ginsenoside Rg1, a natural steroidal saponin found in ginseng, against chronic stress-induced depression.The results showed that chronic administration of ginsenoside Rg1 (40 mg/kg, i.p., 5 weeks) significantly ameliorated depression-like behaviours in rats as assessed in the sucrose preference and forced swim tests. Furthermore, chronic stress decreased the phosphorylation levels of the extracellular signal-regulated kinase and cAMP-response element-binding protein in the prefrontal cortex as well as producing a reduction of brain-derived neurotrophic factor expression. Of particular importance, all reductions in these parameters were significantly reversed by pre-treatment with ginsenoside Rg1. Taken together, the results of the present study suggest that the antidepressant-like effect of ginsenoside Rg1 might be mediated, at least in part, by activating the cAMP-response element-binding protein–brain-derived neurotrophic factor system within the prefrontal cortex. These findings not only reveal some of the underlying neuronal mechanisms of depression, but also the therapeutic potential of ginsenoside Rg1 as a preventive agent in the treatment of depression. © 2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd
Yu S.Y.,Shandong University |
Gao R.,Jinan Nursing Vocational College |
Zhang L.,Shandong University |
Luo J.,Shandong University |
And 2 more authors.
Progress in Neuro-Psychopharmacology and Biological Psychiatry | Year: 2013
Ethanol consumption has well-known deleterious effects on memory. However, the mechanism by which ethanol exerts its effects on memory has received little attention, which has retarded the identification and development of effective therapeutic strategies against ethanol toxicity. The aim of this study was to explore the neuronal mechanisms underlying the protective action of curcumin, a natural polyphenolic compound of Curcuma longa, against ethanol-induced memory deficits. Adult mice were pretreated with curcumin (40. mg/kg, i.p.) before administration of ethanol (1. g/kg, i.p.) for the memory acquisition measurement, or were sacrificed 30. min later for evaluation of regional brain differences in the nitric oxide synthase (NOS) activity and nitric oxide (NO) concentration. The results showed that pretreatment with curcumin significantly ameliorated the memory deficits resulting from acute ethanol administration to mice in the novel object recognition and inhibitory avoidance tasks. Furthermore, acute ethanol treatment increased the NOS activity and NO production in brain regions associated with memory including prefrontal cortex (PFC), amygdala and hippocampus, while this enhancement was suppressed by pretreatment with curcumin. Taken together, these results suggest that the protective effects of curcumin on acute ethanol-induced memory deficits are mediated, at least in part, by suppressing NOS activity in the brain of mice. Thus, manipulation of the NOS/NO signaling pathway might be beneficial for the prevention of ethanol toxicity. © 2013 Elsevier Inc.
Yan J.-K.,Shandong University |
Wang Y.-Z.,Jinan Nursing Vocational College |
Tian C.,Shandong University |
Liu S.-D.,Shandong University |
And 6 more authors.
Central European Journal of Medicine | Year: 2014
Objective. The aim of this study was to examine the expression patterns of CEACAM5 in prostatic non-neoplastic and neoplastic lesions and further investigate its relationship with tumor microvessel density(MVD) and lymphatic vessel density(LVD). Methods. CEACAM5 expression was detected using immunohistochemical staining in a serial sections of the benign prostatic hyperplasia (BPH), prostate intraepithelial neoplasia (PIN) and prostate carcinoma (PCa) lesions. MVD and LVD were quantified in CEACAM5 positive areas by dual-labelling with CD34 and D2-40 respectively. Results. Both PIN and PCa had significantly higher expression for CEACAM5 than BPH which has no positive expression for CEACAM5(P<0.05). In PIN and PCa, CEACAM5 staining showed different expression patterns in terms the of most of membranous staining for PIN, less membranous staining and more cytoplasmic staining for PCa. MVD results showed that PCa and PIN had more angiogenesis than BPH tissue. The value of MVD in PCa tissue was correlated with tumor Gleason grading (P<0.05). LVD results showed that neoplastic lesions had more lymphangiogenesis than non-neoplastic lesion. Conclusion. CEACAM5 had different expression patterns in prostatic non-neoplastic and neoplastic lesions, and these various expression patterns may be correlated with tumor progression through promoting tumorous angiogenesis or lymphangiogenesis. © 2014 Versita and Springer-Verlag.
Hua Z.,Jinan Nursing Vocational College |
Guodong L.,Peoples Bank of China |
Tengfei Z.,China Construction Seventh Engineering Division Corporation
Proceedings - 2013 6th International Conference on Business Intelligence and Financial Engineering, BIFE 2013 | Year: 2014
This paper present it is necessary to develop low carbon economy in China. Additionally, considering the current development status of the low carbon economy in China, this paper puts forward relevant policy suggestions on China's low carbon economy in three aspects of legal measures, economic measures and administrative measures. © 2013 IEEE.
Wang J.,Shandong Jiaotong University |
Zhuang Y.,Jinan Nursing Vocational College
Advanced Materials Research | Year: 2012
For industrial robot manipulator system, PD control theory is extensively used in the dynamic characteristics controlling. A PD robust controller is introduced to optimize the stability and convergence of traditional PD controller and avoid excess initial driving torque for two-link industrial manipulator system. By the co-simulation on ADAMS and Matlab/Simulink, the paper designs a PD robust controller under given upper bound disturbance and completes track control and driving torque trial. Through result comparison and analysis, the superiority of the PD robust controller for two-link manipulator is verified. © (2012) Trans Tech Publications.