PubMed | Jinan University of Lebanon, Tunis el Manar University, Service de Pediatrie and University of Monastir
Type: Journal Article | Journal: Clinical genetics | Year: 2016
Genetic diseases in the Tunisian population represent a real problem of public health as their spectrum encompasses more than 400 disorders. Their frequency and distribution in the country have been influenced by demographic, economic and social features especially consanguinity. In this article, we report on genetic disease association referred to as comorbidity and discuss factors influencing their expressivity. Seventy-five disease associations have been reported among Tunisian families. This comorbidity could be individual or familial. In 39 comorbid associations, consanguinity was noted. Twenty-one founder and 11 private mutations are the cause of 34 primary diseases and 13 of associated diseases. As the information dealing with this phenomenon is fragmented, we proposed to centralize it in this report in order to draw both clinicians and researchers attention on the occurrence of such disease associations in inbred populations as it makes genetic counseling and prenatal diagnosis challenging even when mutations are known.
Tabbouche O.S.,Jinan University of Lebanon |
Soukkariyyeh I.,Jinan University of Lebanon |
Naji M.,Jinan University of Lebanon |
Alwan T.,Jinan University of Lebanon
International Journal of ChemTech Research | Year: 2013
Paracetamol or chemically named p-acetyl-N-aminophenol is a unique analgesic and antipyretic widely used in the hospital setting all over the globe. The Paracetamol solution for IV infusion is clinically the standard analgesic in Pain Management and the first line, most safe antipyretic especially in the Pediatrics Department. According to many pharmacopoeias, the UV spectroscopy is still one of the most validated and relied on quality control assays in pharmaceutical research. Our research objective is to compare the purity and quantity of the Active Pharmaceutical Ingredient (API) "Paracetamol" in five different brands of Paracetamol solution for IV infusion present in the Lebanese market.The Amax was 244nm in all five brands which confirms purity of the API, however Amax was the highest in Bofalgan (Bosch Pharma) and lowest in Perfumol (Hikma Pharmaceuticals). The highest concentration was observed in Perfalgan (Bristol Myers Squibb), while the lowest concentration was observed in Perfumol (Hikma Pharmaceuticals).
Tabbouche O.S.,New Mazloum Hospital |
Soukkariyyeh I.,Jinan University of Lebanon
Journal of Taibah University Medical Sciences | Year: 2014
Objective Imipenem-cilastatin is a well-established broad-spectrum intravenous antibiotic used for the treatment of life-threatening infections worldwide. The preparation has been studied by various methods but not by ultraviolet (UV) spectroscopy, although this technique remains one of the simplestf, most accurate and precise validated quality control laboratory methods. The aim of this study was to validate a method for separating the intercalating peaks of the UV spectra of imipenem and cilastatin and to compare the purity and quantities of these two active ingredients in different marketed brands. No previous studies have been conducted to compare the generic product (Cilanem®) with the original (Tienam®).Methods: First-order derivative UV spectrophotometry was used to separate the intercalating peaks of imipenem and cilastatin by measuring absorbance at 243 nm and 300 nm, respectively.Results: Cilanem® had better physical characteristics and a higher cilastatin concentration, while the brand product Tienam® contained a higher concentration of imipenem.Conclusion: The generic product Cilanem® is at least non-inferior to the brand product Tienam®. © 2014 Taibah University. Production and hosting by Elsevier Ltd. All rights reserved.
PubMed | Jinan University of Lebanon and Cornell College
Type: Journal Article | Journal: Global cardiology science & practice | Year: 2015
Genetic disorders are not equally distributed over the geography of the Arab region. While a number of disorders have a wide geographical presence encompassing 10 or more Arab countries, almost half of these disorders occur in a single Arab country or population. Nearly, one-third of the genetic disorders in Arabs result from congenital malformations and chromosomal abnormalities, which are also responsible for a significant proportion of neonatal and perinatal deaths in Arab populations. Strikingly, about two-thirds of these diseases in Arab patients follow an autosomal recessive mode of inheritance. High fertility rates together with increased consanguineous marriages, generally noticed in Arab populations, tend to increase the rates of genetic and congenital abnormalities. Many of the nearly 500 genes studied in Arab people revealed striking spectra of heterogeneity with many novel and rare mutations causing large arrays of clinical outcomes. In this review we provided an overview of Arab gene geography, and various genetic abnormalities in Arab populations, including disorders of blood, metabolic, circulatory and neoplasm, and also discussed their associated molecules or genes responsible for the cause of these disorders. Although studying Arab-specific genetic disorders resulted in a high value knowledge base, approximately 35% of genetic diseases in Arabs do not have a defined molecular etiology. This is a clear indication that comprehensive research is required in this area to understand the molecular pathologies causing diseases in Arab populations.
Postgraduate Studies Ever since it was founded in 1988, Jinan University has worked hard to spread knowledge among the students of the Arab World through its updating academic programs. In order to achieve its mission, it has launched the Postgraduate Studies Department in 1993 to enable the students to continue their higher studies and receive graduate degrees by conducting valuable research that meets modern academic standards ...
Jinan University of Lebanon | Entity website
PubMed | Jinan University of Lebanon, CNRS Center for Molecular Biophysics, French Institute of Health and Medical Research and University of Tours
Type: Journal Article | Journal: Oncotarget | Year: 2016
Expression of the antimicrobial peptide hCAP18/LL-37 is associated to malignancy in various cancer forms, stimulating cell migration and metastasis. We report that LL-37 induces migration of three cancer cell lines by activating the TRPV2 calcium-permeable channel and recruiting it to pseudopodia through activation of the PI3K/AKT pathway. Ca2+ entry through TRPV2 cooperated with a K+ efflux through the BKCa channel. In a panel of human breast tumors, the expression of TRPV2 and LL-37 was found to be positively correlated. The D-enantiomer of LL-37 showed identical effects as the L-peptide, suggesting that no binding to a specific receptor was involved. LL-37 attached to caveolae and pseudopodia membranes and decreased membrane fluidity, suggesting that a modification of the physical properties of the lipid membrane bilayer was the underlying mechanism of its effects.