Guangzhou, China
Guangzhou, China

Jinan University is a public research and comprehensive university based in Guangzhou, Guangdong province, China. It is one of the oldest universities established on mainland China tracing back to the Qing Empire. Its mission is to spread Chinese learning and culture from North to South, and from China overseas. Jinan University was the first university in China to recruit foreign students, and is currently the Chinese university with the largest number of international students.In 1996, it was included in the state's Project 211 for development of key universities. It is a university administered by the Overseas Chinese Affairs Office of the State Council and the Chinese Ministry of Education. Wikipedia.

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Wu B.,Jinan University | Dong D.,University of Houston
Trends in Pharmacological Sciences | Year: 2012

Glutathione transferases (GSTs) are important detoxifying enzymes that catalyze the conjugation of electrophilic substrates to glutathione. In recent years, GSTs have been of great interest in pharmacology and drug development because of their involvement in many important biological processes such as steroid and prostaglandin biosynthesis, tyrosine catabolism, and cell apoptosis. This review describes crystal structures for cytosolic GSTs and correlates active-site features with enzyme functions (e.g., steroid synthesis, tyrosine degradation, and dehydroascorbate reduction) and substrate selectivity. Use of these crystal structures for the design of specific inhibitors for several GST enzymes is also discussed. © 2012 Elsevier Ltd.

Xiang Q.,Jinan University
Burns : journal of the International Society for Burn Injuries | Year: 2011

The basic fibroblast growth factor (bFGF) has a very short half-life in vivo, and this limits its therapeutic value for frequent administration. Liposome technology was used to improve the stability of bFGF and to prolong its effects in vivo. bFGF-encapsulated liposomes (bFGF-lip) were prepared using the pH gradient method. Four critical factors were investigated including concentration of citric acid solution, incubation time of blank liposomes, incubation temperature and sonication time. The pharmacodynamics of bFGF-lip was investigated by establishing a deep second-degree burns model in rats. The optimal bFGF-lip were characterised by high entrapment efficiency (79.88 ± 3.37%), good physical stability (K(E): 1.02 ± 0.413%) and high bioactivity ((6.147 ± 0.769) × 10(5) IU ml(-1)). The middle dose of bFGF-lip (60 IU ml(-1)) demonstrated the fastest tissue collagen generation as well as the earliest and highest tumour growth factor (TGF)-β1 and dermal cell proliferation (proliferating cell nuclear antigen (PCNA)) expression as compared with other treatments. Results of the present study imply that bFGF-lip have promising prospects for application in wound-healing therapies. Copyright © 2011 Elsevier Ltd and ISBI. All rights reserved.

Carnosine (β-alanyl-L-histidine), a naturally occurring dipeptide, has been characterized as a putative neurotransmitter and serves as a reservoir for brain histamine, which could act on histaminergic neurons system to relieve stress-induced damages. However, understanding of the role of carnosine in stress-evoked immunocompromise is limited. In this study, results showed that when mice were subjected to restraint stress, spleen index and the number of spleen lymphocytes including Natural Killer (NK) cells were obviously decreased. Results also demonstrated that restraint stress decreased the cytotoxic activity of NK cells per spleen (LU(10)/spleen) while the activity of a single NK cell (LU(10)/10(6) cells) was not changed. However, oral administration of carnosine (150 and 300 mg/kg) increased spleen index and number of spleen lymphocytes (including NK cells), and elevated the cytotoxic activity of NK cells per spleen in restraint-stressed mice. These results indicated that carnosine ameliorated stress-evoked immunocompromise through spleen lymphocyte number maintenance. Carnosine was further found to reduce stress-induced elevation of plasma corticosterone level. On the other hand, results showed that carnosine and RU486 (a glucocorticoids receptor antagonist) treatment prevented the reduction in mitochondrion membrane potential and the release of mitochondrial cytochrome c into cytoplasm, increased Bcl-2/Bax mRNA ratio, as well as decreased terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL)-positive cells in spleen lymphocytes of stressed mice. The results above suggested that the maintenance of spleen lymphocyte number by carnosine was related with the inhibition of lymphocytes apoptosis caused by glucocorticoids overflow. The stimulation of lymphocyte proliferation by carnosine also contributed to the maintenance of spleen lymphocyte number in stressed mice. In view of the elevated histamine level, the anti-stress effects of carnosine on restraint-evoked immunocompromise might be via carnosine-histamine metabolic pathway. Taken together, carnosine maintained spleen lymphocyte number by inhibiting lymphocyte apoptosis and stimulating lymphocyte proliferation, thus prevented immunocompromise in restraint-stressed mice.

Nuclear receptor Rev-erbα plays important roles in circadian clock timing, lipid metabolism, adipogenesis, and vascular inflammation. However, the role of Rev-erbα in atherosclerotic lesion development has not been assessed in vivo. The nuclear receptor Rev-erbα was knocked down in mouse haematopoietic cells by means of shRNA-lentiviral transduction, followed by bone marrow transplantation into LDL receptor knockout mice. The Rev-erbα protein in peripheral macrophage was reduced by 70% as compared to control mice injected with nontargeting shRNA lentivirus-transduced bone marrow. A significant increase in atherosclerotic lesions was observed around the aorta valves as well as upon en face aorta analysis of Rev-erbα knock-down bone marrow recipients (P<0.01) as compared to the control mice, while plasma cholesterol, phospholipid, and triacylglycerol levels were not affected. Overexpression of Rev-erbα in bone marrow mononuclear cells decreased inflammatory M1 while increasing M2 macrophage markers, while Rev-erbα knock down increased the macrophage inflammatory phenotype in vitro and in vivo. Furthermore, treatment of differentiating macrophages with the Rev-erbα ligand heme promoted expression of antiinflammatory M2 markers. These observations identify hematopoietic cell Rev-erbα as a new modulator of atherogenesis in mice.

Xue J.,Jinan University
Thin-Walled Structures | Year: 2012

This paper presents a unique approach to analyze the buckling of an infinitely long cylindrical shell subjected to the external pressure. Buckling is considered to occur locally in the shell, spreading over a certain length along the longitudinal axis of the shell. A plausible function of the flexural displacement is created according to Timonshenkos ring solution of the transverse collapse mode. The governing equations based on DonnellMYVTAPNs shell theory are solved using Ritz method and the equilibrium conditions are educed. Numerical computations are performed for cases when shell thickness/radius ratios are 0.1, 0.05 and 0.03. In general, the pressure decreases sharply with a very slight increase of the normalized radial deflection just at the beginning of the initiation, then falls quite slowly till the two opposite points on the inner surface of the shell contact each other. It is found that the buckling pressure of the shell converges to the critical value given by DonnellMYVTAPNs shell theory and the span of the buckling mode in the longitudinal axis of the shell is independent of material properties. Solutions given in this paper can be used to address the problem of steady-state buckle propagation in the shells. © 2012 Elsevier Ltd. All rights reserved.

Zhong W.-R.,Jinan University
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics | Year: 2010

A double-stranded system, modeled by a Frenkel-Kontorova lattice, is studied through nonequilibrium molecular dynamics simulations. We have investigated the thermal conductance influenced by the intrachain interaction as well as by the interchain interaction. It is found that the intrachain interaction always enhance the thermal conductance. The interchain interaction, however, has a positive effect on the thermal conductance in the case of strong nonlinear potential, and has a negative effect on the thermal conductance in the case of weak nonlinear potential. This phenomenon can be explained by the transition of thermal transport mode and the phonon band shift of the particles. It is suggested that the inter- and intrachain interactions present different thermal properties in double-stranded lattices. © 2010 The American Physical Society.

A scheme to generate a frequency-locked multicarrier based on a complementary frequency shifter (CFS) with double recirculating frequency-shifting loops has been proposed and analyzed theoretically. The transfer function and output properties of a CFS-based multicarrier generator (CMCG) have been derived. Based on our analysis, 100 carriers have been obtained with acceptable flatness under perfect and imperfect operation conditions. The results show that the proposed CMCG can achieve hundreds of frequency-locked carriers used in various scenarios. © 2013 Optical Society of America.

Yang P.,Jinan University | Mai W.,Jinan University
Nano Energy | Year: 2014

With the proliferation of microelectronic devices, the need for portable power supplies is evidently increasing. Possible candidates for micro energy storage devices are Li-ion batteries and supercapacitors. Among them, the flexible solid-state supercapacitors combined with exceptionally long cycle life, high power density, environmental friendliness, safety, flexibility and stability, afford a very promising option for energy storage applications. This paper reviews flexible solid-state electrochemical supercapacitors and the performance metrics. A better practice by calculating released energy to evaluate material and device performance is proposed. In addition, an overview is given of the electrolyte and various electrode materials that are suitable for flexible solid-state supercapacitors. The review summarizes the recent research focusing on novel configurations of flexible solid-state supercapacitors for energy storage and applications, such as freestanding, asymmetric, interdigitated, and fiber-based supercapacitors. Lastly, some discussions on future research are presented. © 2014 Elsevier Ltd.

A configuration of all-optical switching based on a Signac loop mirror that incorporates an ytterbiumdoped fiber and uniform fiber Bragg grating (FBG) is proposed in this paper. It is found that the transmission spectrum of this structure is the narrow splitting of the reflection spectrum of the FBG. The shift of this ultranarrow transmission spectrum is very sensitive to the intensity of the pump power. Thus, the threshold switching power can be greatly reduced by shifting such narrow transmission spectrum. Compared with the single FBG, the threshold switching power of this configuration is reduced by 4 orders of magnitude. In addition, the results indicate that this optical switching has a high extinction ratio of 20 dB and a ultrafast response time of 3 ns. The operation regime and switching performance under the cross-phase modulation cases are also investigated. © 2013 Optical Society of America.

Deng Y.,Jinan University
ACM Computing Surveys | Year: 2011

Disk drives have experienced dramatic development to meet performance requirements since the IBM 1301 disk drive was announced in 1961. However, the performance gap between memory and disk drives has widened to 6 orders of magnitude and continues to widen by about 50% per year. Furthermore, energy efficiency has become one of the most important challenges in designing disk drive storage systems. The architectural design of disk drives has reached a turning point which should allow their performance to advance further, while still maintaining high reliability and energy efficiency. This article explains how disk drives have evolved over five decades to meet challenging customer demands. First of all, it briefly introduces the development of disk drives, and deconstructs disk performance and power consumption. Secondly, it describes the design constraints and challenges that traditional disk drives are facing. Thirdly, it presents some innovative disk drive architectures discussed in the community. Fourthly, it introduces some new storage media types and the impacts they have on the architecture of the traditional disk drives. Finally, it discusses two important evolutions of disk drives: hybrid disk and solid state disk. The article highlights the challenges and opportunities facing these storage devices, and explores how we can expect them to affect storage systems. © 2011 ACM.

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