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Wang H.,Shandong University | Tao Y.,Jinan Second Peoples Hospital | Sun X.-L.,Yantai Yuhuangding Hospital | Zhuang K.,Shandong University
Journal of International Medical Research | Year: 2013

ObjectiveTo determine the value of optic disc parameters and perimetric defects in the early diagnosis of patients with primary open-angle glaucoma (POAG).MethodsOptic disc parameters and perimetry were compared among patients in the early stage of POAG, patients with suspected POAG and healthy control subjects, using Heidelberg retina tomography (HRT-II), optical coherence tomography (OCT) and a Humphrey 750i automatic field analyser, in order to determine whether these parameters could be used for early POAG diagnosis.ResultsA total of 55 participants were enrolled in the study. Significant differences in the optic disc parameter and perimetry values were observed between the three groups. HRT-II parameters showed good correlation with OCT parameters. The majority of the HRT-II and OCT parameters showed a good correlation with perimetry values.ConclusionsHRT-II and OCT optic disc parameters both reflect morphological changes of the optic disc. These current findings suggest that they can both detect glaucomatous optic neuropathy earlier than a white-on-white perimetry examination. In addition, OCT can detect optic disc parameter changes that cannot be detected by HRT-II. © The Author(s) 2013. Source

Ji Y.,Shandong Cancer Hospital and Institute | Han Z.,Jinan Second Peoples Hospital | Shao L.,Shandong Cancer Hospital and Institute | Li Y.,Shandong Cancer Hospital and Institute | And 2 more authors.
OncoTargets and Therapy | Year: 2015

Acute pancreatitis is a rare complication in postoperative colorectal cancer patients after FOLFOX6 (oxaliplatin + calcium folinate +5-FU [5-fluorouracil]) chemotherapy. In this paper, a total of 62 patients with gastrointestinal cancer were observed after the burst of acute pancreatitis. Surgery of the 62 cases of colorectal cancer patients was completed successfully. But when they underwent FOLFOX6 chemotherapy, five patients got acute pancreatitis (8.06%), four (6.45%) had mild acute pancreatitis, and one (1.61%) had severe acute pancreatitis, of which two were males (3.23%) and three females (4.84%). No patients (0.00%) had acute pancreatitis on the 1st day after chemotherapy; one patient (1.61%) got it in the first 2 and 3 days after chemotherapy; and three others (4.83%) got it in the first 4 days after chemotherapy. In the 62 patients with malignant tumors, the body mass index (BMI) was less than 18 (underweight) in six of them, with two cases of acute pancreatitis (33.33%); the BMI was 18–25 (normal weight) in 34 cases, with one case (2.94%) of acute pancreatitis; the BMI was 25–30 (overweight) in 13 cases, with 0 cases (0.00%) of acute pancreatitis; and the BMI was ≥30 (obese) in nine patients, with two cases of acute pancreatitis (22.22%). After symptomatic treatment, four patients were cured and one died; the mortality rate was 1.61%. Most of them appeared in the first 4 days after chemotherapy; the probability of this complication is significantly higher in slim and obese patients than in normal weight patients. Postoperative colorectal cancer patients after FOLFOX6 chemotherapy have a sudden onset of acute pancreatitis occult, especially in patients with severe acute pancreatitis; the symptoms are difficult to control, there is high mortality and it is worthy of clinician’s attention. © 2015 Ji et al. Source

Shen T.,Shandong University | Zhang L.,Jinan Second Peoples Hospital | Wang Y.-Y.,Shandong University | Fan P.-H.,Shandong University | And 3 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2012

Two new stigmastane-type steroids, stigmasta-5,22E-diene-3β,11α- diol (1) and stigmasta-5,22E-diene-3β,7α,11α-triol (2), together with eight known compounds, were isolated from the resinous exudates of Commiphora mukul. Their structures were established by extensive analysis of their HR-MS, 1D- and 2D-NMR (COSY, HMQC, HMBC and NOESY) spectra. The isolates were evaluated for their antiproliferative activities against four human cancer cell lines. Compound 2 demonstrated inhibitory effects with IC50 values of 5.21, 9.04, 10.94 and 16.56 μM, respectively, against K562, MCF-7, PC3 and DU145 human cancer cell lines. Further study showed that 2 was able to enforce the PC3 cell cycle arrest in the G2/M phase, and induce the apoptosis of PC3 cells by activation of Bax, caspases 3 and 9, and by inhibition of Bcl-2. It was also found that 1 inhibited proliferation of PC3 cells via G0/G1 phase arrest of the cell cycle. © 2012 Elsevier Ltd. All rights reserved. Source

Cai D.,Shandong University | Zhao J.,Jinan Second Peoples Hospital | Sun Q.,Shandong University
Journal of International Medical Research | Year: 2014

Objectives:The aims of this study were to investigate the incidence of Krüppel-like factor 6 (KLF6) protein staining in patients with cutaneous malignant melanoma and examine its potential relevance to clinicopathological characteristics and tumour cell proliferation.Methods:Clinicopathological data from patients with cutaneous malignant melanoma were analysed retrospectively. Presence of KLF6 and the antigen Ki-67 in malignant melanoma and healthy tissue samples from each patient was detected by immunohistochemistry. The proliferation index was calculated on the basis of Ki-67 expression. The relationship between KLF6 and clinicopathological characteristics was also analysed.Results:KLF6 was detected more frequently in normal healthy skin tissue compared with cutaneous malignant melanoma lesions (n = 40). There was a negative correlation between the presence of KLF6 and the proliferation index. The presence of KLF6 was also significantly correlated with tumour diameter, lymph node metastasis, tumour-node-metastasis stage and 3-year survival rate.Conclusions:KLF6 protein is downregulated in human cutaneous malignant melanoma lesions compared with healthy skin tissue. KLF6 may be involved in tumour progression and may be a tumour suppressor and prognostic marker for cutaneous malignant melanoma. © The Author(s) 2013. Source

Jian J.,Shandong University | Guoying W.,Weifang Medical University | Jing Z.,Jinan Second Peoples Hospital
Journal of International Medical Research | Year: 2013

Objectives: To observe sex determining region Y-box 11 (SOX11) gene expression in cutaneous malignant melanoma and its effect on tumour cell proliferation. Methods: Clinicopathological data and tissue samples from patients with cutaneous malignant melanoma, together with tissue samples from healthy volunteers (controls), were retrospectively reviewed. Protein levels of SOX11 and the antigen identified by monoclonal antibody Ki-67 (Ki-67) in skin lesions were analysed using immunohistochemistry. The correlation between protein levels and clinipathological parameters was investigated. Results: Out of 40 patient samples, 25 (62.5%) were positive for SOX11 protein in malignant melanoma tissue. This was significantly higher than in 40 control tissue samples, in which no SOX11 protein was detected. Presence of SOX11 protein was positively related to the proliferation index of cutaneous malignant melanoma tumour cells. Presence of SOX11 protein in cutaneous malignant melanoma was related to tumour type, tumour location, lymph nodemetastasis and 5-year survival rate. Conclusion: Human cutaneous malignant melanoma tissues expressed high levels of SOX11 compared with healthy controls, suggesting that SOX11 may be a new prognostic marker for malignant melanoma. © The Author(s) 2013. Source

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