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Nie H.,Soochow University of China | Xu Y.,Soochow University of China | Liu B.,Jinan Institute of Cardiovascular Disease | Zhang Y.,Soochow University of China | And 4 more authors.
International Journal of Geriatric Psychiatry | Year: 2011

Background Dementia has been a major public health problem and mild cognitive impairment is considered the pre-dementia syndrome in recent years. However, there has not yet been a systematic analysis of the prevalence of mild cognitive impairment in China. Objectives The aim of this study was to analyse the prevalence of mild cognitive impairment among the population aged 60 years and older in China. Methods Epidemiological investigations on mild cognitive impairment in China published in journals were identified manually and online by using CBMDISK, ChongqingVIP database and CNKI database. Those reported in English journals were identified using MEDLINE. Selected studies had to describe an original study defined by strict screening and diagnlstic criteria. The fixed effects model or random effects model was employed according to statistical test for homogeneity. Results Twenty-two studies were selected, the statistical information of which was collected for systematic analysis. The results showed that the pooled prevalence of MCI for the elderly population was 12.7% (95% CI: 9.7-16.5%). In eastern and western China, the prevalence of MCI was 9.6 and 14.7%, respectively. There was a higher prevalence of MCI in the illiterate elderly population than in those who received years of education. Conclusions The prevalence of MCI affected by sex, age,education, which was lower in eastern than that in western China. Copyright © 2010 John Wiley & Sons, Ltd. Source


B L.,Jinan Institute of Cardiovascular Disease | T W.,Jinan Institute of Cardiovascular Disease | Hn Z.,Jinan Institute of Cardiovascular Disease | Ww Y.,Jinan Institute of Cardiovascular Disease | And 5 more authors.
BMC Public Health | Year: 2011

Background: The prevalence of hyperuricemia varied in different populations and it appeared to be increasing in the past decades. Recent studies suggest that hyperuricemia is an independent risk factor for cardiovascular disease. However, there has not yet been a systematic analysis of the prevalence of hyperuricemia in China. Methods. Epidemiological investigations on hyperuricemia in China published in journals were identified manually and on-line by using CBMDISC, Chongqing VIP database and CNKI database. Those Reported in English journals were identified using MEDLINE database. Selected studies had to describe an original study defined by strict screening and diagnostic criteria. The fixed effects model or random effects model was employed according to statistical test for homogeneity. Results: Fifty-nine studies were selected, the statistical information of which was collected for systematic analysis. The results showed that the pooled prevalence of hyperuricemia in male was 21.6% (95%CI: 18.9%-24.6%), but it was only 8.6% (95%CI: 8.2%-10.2%) in female. It was found that thirty years was the risk point age in male and it was fifty years in female. Conclusions: The prevalence of hyperuricemia is different as the period of age and it increases after 30 years in male and 50 in female. Interventions are necessary to change the risk factors before the key age which is 30 years in male and 50 in female. © 2011B et al; licensee BioMed Central Ltd. Source


Ma S.T.,Shandong University | Ma S.T.,Jinan Institute of Cardiovascular Disease | Zhao W.,Shandong Jiaotong HospitalShandong | Liu B.,Jinan Institute of Cardiovascular Disease | And 3 more authors.
Genetics and Molecular Research | Year: 2015

Numerous studies have evaluated the association between Arg389Gly polymorphism in the β1 adrenergic receptor gene and heart failure risk. However, the specific association is still controversial. We performed a meta-analysis of all case-control studies that evaluated the association between Arg389Gly polymorphism and heart failure in humans. Studies were identified in the PubMed, Embase, and China National Knowledge Infrastructure databases. Two reviewers independently assessed the studies. Six case-control studies with a total of 1736 participants were included in the meta-analysis, including 882 cases with heart failure and 854 controls, and our results showed no association between the Arg389Gly polymorphism and heart failure [ArgArg vs GlyGly: odds ratio (OR) = 0.84, 95% confidence interval (CI) 0.59-1.20; ArgArg vs ArgGly: OR = 0.95, 95%CI 0.78-1.16; dominant model: OR = 1.08, 95%CI 0.89-1.31; recessive model: OR = 0.96, 95%CI 0.69-1.35]. No publication bias was found in the present study (all P values > 0.05). In conclusion, the β1 adrenergic receptor gene Arg389Gly polymorphism might not be associated with heart failure risk. Further large and well-designed studies are needed to confirm this conclusion. © FUNPEC-RP. Source


Yue W.-W.,Jinan Institute of Cardiovascular Disease | Yin J.,Jinan Institute of Cardiovascular Disease | Chen B.,Jinan Institute of Cardiovascular Disease | Zhang X.,Jinan Institute of Cardiovascular Disease | And 4 more authors.
Cell Biochemistry and Biophysics | Year: 2014

To investigate heart rate variability (HRV) in patients with masked hypertension (MH), participants were classified based on clinic and 24-h ambulatory blood-pressure monitoring: essential hypertension (EH, n = 40; MH, n = 36) and normotension (NT, n = 48). The HRV parameters were observed using a 24-h Holter monitor. Compared with NT controls, the parameters of HRV (SDNN, SDANN, SDNN Index, RMSSD, HF) and parameters in EH and MH patients had significantly decreased. No statistically significant difference in the HRV parameters was found between the EH and MH groups. The changes in HRV parameters show cardiac autonomic nerve dysfunction in patients with MH. © 2014 Springer Science+Business Media New York. Source

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